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Ibuprofen sustained-release pellet and preparation method thereof

A technology of sustained-release pellets and sustained-release materials, applied in the field of medicine, can solve the problems of poor sustained-release effect and difficult control of drug release, and achieve good sustained-release effect, stable sustained-release effect, and stable sustained-release effect. Effect

Active Publication Date: 2016-02-24
XINAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the above-mentioned patents all realize the slow-release effect through the erosion of the blank core, and the drug release rate is not easy to control, and the slow-release effect is not good.

Method used

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  • Ibuprofen sustained-release pellet and preparation method thereof
  • Ibuprofen sustained-release pellet and preparation method thereof
  • Ibuprofen sustained-release pellet and preparation method thereof

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preparation example Construction

[0055] The present invention also provides a preparation method of the ibuprofen sustained-release pellets described in the above technical scheme, comprising the following steps:

[0056] a) granulating after mixing ibuprofen, disintegrating agent, filler and binding agent to obtain drug-containing pills; the disintegrating agent is microcrystalline cellulose;

[0057] b) coating the drug-containing pill with a sustained-release material to obtain ibuprofen sustained-release pellets;

[0058] The sustained-release material is polymethacrylate or ethyl cellulose.

[0059] In the present invention, the ibuprofen, the disintegrating agent, the filler and the binding agent are mixed and granulated to obtain the drug-containing pill. In the present invention, the ibuprofen is the main ingredient; the source of the ibuprofen is not particularly limited in the present invention, and commercially available products well known to those skilled in the art can be used. In the present ...

Embodiment 1

[0096] (1) Stir and mix 200g ibuprofen bulk drug, 90gMCCPH302, and 10gLAC in a HLSH2-6 wet mixing granulator, the stirring chassis rotating speed is 600rpm, and the side disk rotating speed is 1200rpm to obtain mixed powder; then keep stirring Conditions remain the same, 100 g of 10% PVPK30 aqueous solution is added to the above mixed powder to obtain a soft material.

[0097] (2) Move the above-mentioned soft material to the E50 extruder, and extrude it for 2 minutes under the condition of extrusion speed of 30rpm to obtain a strip; then the above-mentioned strip is spheronized in the s-250 spheronizer After 3 minutes, the rotating speed of spheronizing is 1200rpm to obtain vegetarian pills; then the above-mentioned vegetarian pills are dried in a CS101-2ABN type hot air circulation box for 12 hours at a drying temperature of 40°C; finally passed through a 20-30 mesh sieve to obtain drug-containing vegetarian pills.

[0098] (3) get 16.7g Eudragit NE30D water dispersion, 28g ...

Embodiment 2

[0105] (1) Stir and mix 200g ibuprofen crude drug, 80gMCCPH302, and 20gLAC in the HLSH2-6 type wet mixing granulator, the chassis rotation speed of stirring is 600rpm, and the side disk rotation speed is 1200rpm to obtain the mixed powder; then keep stirring Conditions remain the same, 100 g of 10% PVPK30 aqueous solution is added to the above mixed powder to obtain a soft material.

[0106] (2) Move the above-mentioned soft material to the E50 extruder, and extrude it for 2 minutes under the condition of extrusion speed of 30rpm to obtain a strip; then the above-mentioned strip is spheronized in the s-250 spheronizer After 3 minutes, the rotating speed of spheronizing is 1200rpm to obtain vegetarian pills; then the above-mentioned vegetarian pills are dried in a CS101-2ABN type hot air circulation box for 12 hours at a drying temperature of 40°C; finally passed through a 20-30 mesh sieve to obtain drug-containing vegetarian pills.

[0107] (3) Get 32g Surelease aqueous disper...

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Abstract

The invention provides an ibuprofen sustained-release pellet and a preparation method thereof. The ibuprofen sustained-release pellet comprises a medicine-containing pill and a sustained-release material coating the surface of the medicine-containing pill; the medicine-containing pill is prepared from the following components in parts by weight: 55-75 parts of ibuprofen, 15-35 parts of disintegrating agent, 1-15 parts of filler and 1-5 parts of binder; the disintegrating agent is microcrystalline cellulose; the sustained-release material is poly methacrylate or ethyl cellulose. The preparation method of the ibuprofen sustained-release pellet comprises the steps of firstly evenly dispersing the ibuprofen in the medicine-containing pill, and then coating by means of the sustained-release material to obtain the sustained-release pellet. By means of interaction of the disintegrating agent and the sustained-release material, the drug releasing rate can be effectively controlled, so that the sustained-release effect of a product is good and stable.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to an ibuprofen sustained-release pellet and a preparation method thereof. Background technique [0002] Ibuprofen, the chemical name is 2-(4-isobutyl-phenyl) propionic acid, the English name is Ibuprofen, and the molecular formula is C 13 h 18 o 2 , the chemical structural formula is as follows: [0003] [0004] Ibuprofen is a commonly used antipyretic, analgesic and anti-inflammatory drug. It is clinically used for long-term treatment of rheumatism, rheumatoid arthritis and osteoarthritis, and is also widely used for various moderate pain, inflammation and fever. In terms of antipyretic, ibuprofen has the advantages of safety, good antipyretic effect, and long antipyretic time; in terms of analgesia, the analgesic effect of ibuprofen is 16-23 times greater than that of aspirin, and has fewer adverse reactions. In the national basic medical insurance drug catalog, ibuprof...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/192A61K47/38A61K47/32A61P29/00
CPCA61K9/0002A61K9/5026A61K9/5042A61K9/5073A61K31/192A61K47/38
Inventor 李标蒲道俊罗娟朱海游余春梅周成林杨秀丽陈家香
Owner XINAN PHARMA
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