hollow sio 2 Hollow au cage nano rattle, its preparation method and application

A hollow and hollow technology, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problem of low drug loading and other problems, and achieve the effect of improving biocompatibility

Inactive Publication Date: 2017-10-24
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

But solid SiO 2 May shield Raman signal while not addressing low drug loading

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  • hollow sio <sub>2</sub> Hollow au cage nano rattle, its preparation method and application
  • hollow sio <sub>2</sub> Hollow au cage nano rattle, its preparation method and application
  • hollow sio <sub>2</sub> Hollow au cage nano rattle, its preparation method and application

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[0052] In a more specific embodiment, the preparation method may include: first preparing Ag cubes with sodium hydrosulfide-mediated polyol method, and then using HAuCl 4 Convert the Ag cube into a hollow Au cage in a solution at 100°C. Preferably, Raman signal molecules can also be modified on the surface of the hollow Au cage, and coated with SiO at the same time or after 2 layer, and then selectively etch the SiO 2 layer transforms into hollow SiO 2 , preferably, also in SiO 2 Surface modification of biocompatible molecules such as bioactive peptides.

[0053] Further, in a more specific embodiment, a method for preparing the hollow SiO 2 The method for wrapping hollow Au cage nano rattles may comprise the following steps:

[0054] (1) Preparation of Ag cubes

[0055] Using the polyol method, heat ethylene glycol (EG) at 100-200°C for 1-60 min, then add sodium hydrosulfide (NaHS), hydrochloric acid (HCl), polypyrrolidone (PVP) and silver trifluoroacetate (CF) in sequen...

Embodiment 1

[0067] (1) Preparation of Ag cubes

[0068] Using the polyol method, heat 25 mL of ethylene glycol (EG) at 150 °C for 30 min, add 0.3 mL of 3 mM NaHS solution, 2.5 mL of 3 mM hydrochloric acid, and 6.25 mL of 20 mg / mL NaHS solution in sequence. PVP solution and 2.0 mL of CF at a concentration of 282 mM 3 The EG solution of COOAg was heated at 150 °C for 1 h, and the reaction flask was placed in an ice-water bath to stop the reaction, centrifuged, washed with water, and the prepared Ag cubes were dispersed in 10 mL of deionized water. For the morphology, particle size distribution, UV-Vis spectrum and SERS spectrum of the Ag cube, please refer to Figure 1a , Figure 2a , image 3 (line a), Figure 4 (line a).

[0069] (2) Preparation of Au cages

[0070] Using the electrodisplacement reaction method, add 1 mL of the Ag cube dispersion prepared in step (1) to 50 mL of an aqueous solution containing 1 mg / mL PVP, heat to 100 °C, and dissolve 0.2 mM HAuCl 4 The solution was...

Embodiment 2

[0078] (1) Preparation of Ag cubes

[0079] Using the polyol method, heat 25 mL of ethylene glycol (EG) at 160 °C for 30 min, add 0.3 mL of 6 mM NaHS solution, 2.5 mL of 6 mM hydrochloric acid, and 6.25 mL of 20 mg / mL NaHS solution in sequence. PVP solution and 2.0 mL CF3COOAg EG solution with a concentration of 282 mM were heated at 160 °C for 30 min, the reaction flask was placed in an ice-water bath to stop the reaction, centrifuged, washed with water, and the prepared Ag cubes were dispersed in 10 mL deionized water .

[0080] (2) Preparation of hollow Au cages

[0081] Using the electrodisplacement reaction method, add 1 mL of the Ag cube dispersion prepared in step (1) to 50 mL of an aqueous solution containing 2 mg / mL PVP, heat to 70 °C, and add 0.4 mM HAuCl 4 The solution was added dropwise to the reaction solution at a rate of 0.75 mL / min, and the dropwise addition was stopped at 30 min, and the heating was continued for 30 min, and the reaction flask was placed in ...

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Abstract

The invention discloses a hollow SiO2 wrapped hollow Au cage nanometer bell and a preparing method and application thereof. The nanometer bell comprises a hollow SiO2 micro ball and a hollow Au cage movably arranged in an inner cavity of the hollow SiO2 micro ball. The preparing method of the nanometer bell comprises the steps that an Ag cuboid and the like are utilized as a template, the hollow Au cage is manufactured, Raman signal molecule modification and SiO2 shell layer wrapping are carried out on the surface of the Au cage, and an SiO2 wrapped hollow Au cage core-shell structure nanometer particle is formed; and in addition, the selective surface etching is carried out on the core-shell structure nanometer particle, and the nanometer bell is prepared. The nanometer bell has high stability and biocompatibility and can serve as a good medicine carrier, the absorption in a near-infrared area can be adjusted, the light energy of near-infrared lasers is converted into heat energy, meanwhile, the Raman signal can be enhanced, and huge application prospects are achieved in the medical fields such as medicine carrying, photo-thermal treatment and Raman imaging.

Description

technical field [0001] The invention relates to a rattle-type nano material and a preparation method thereof, in particular to a hollow SiO 2 The invention discloses a method for preparing a hollow Au cage nano rattle, which belongs to the field of inorganic materials. technical background [0002] Gold nanomaterials, due to their unique chemical and physical properties, have broad application prospects in the fields of electronics, optics, catalysis and biomedicine. In recent years, a variety of gold nanostructures, including gold nanorods, gold nanoshells and gold nanocages, have attracted extensive attention in the field of biomedicine (N. Li, P. X. Zhao, D. Astruc, Angew. Chem. Int. Ed. 2014, 53, 1756). [0003] The surface of these gold nanostructures has a strong electromagnetic field, which can be used as a surface-enhanced Raman substrate to enhance the Raman molecules adsorbed on the surface, and can be used as a Raman probe for biological detection and imaging ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F1/02B22F9/24B82Y40/00B82Y30/00
Inventor 王强斌胡峰
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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