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Preparation method of adsorbent special for heparin sodium

A heparin sodium and adsorbent technology, applied in chemical instruments and methods, other chemical processes, etc., can solve problems affecting the normal operation of industrial devices, low adsorption capacity of heparin sodium, low mechanical strength, etc., and achieve stable physical and chemical properties and high adsorption Effect, highly selective effect

Active Publication Date: 2016-02-03
JIANGSU WANBANG BIOPHARMLS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The adsorption resins used in the above patents and known technologies are mainly ordinary macroporous weakly basic anion exchange resins, which to a certain extent have the disadvantages of low adsorption capacity of heparin sodium, low mechanical strength, and easy breakage, which affect the normal operation of industrial devices.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of water phase

[0026] Add 1000Kg of pure water and 5 parts of gelatin into a 2000L reactor, and stir evenly;

[0027] (2) Preparation of oil phase

[0028] 100Kg of styrene, 15Kg of divinylbenzene, 0.2Kg of methyl trifluoromethacrylate (FPMMA), 0.3Kg of 4-vinylpyridine, 0.8Kg of benzoyl peroxide, and 30Kg of methyl isobutyl carbinol were stirred Uniform, get the oil phase;

[0029] (3) Suspension polymerization reaction

[0030] Add the oil phase solution prepared in step 2) to the reaction kettle equipped with the prepared water phase in step 1), add the oil phase solution prepared in step 2) to the reactor equipped with the prepared water phase in step 1) reaction kettle, and then reacted from 80 ° C for 12 hours. After the reaction, the reaction mixture was extracted with acetone and dried in vacuum to obtain polymer white balls;

[0031] (4) Functional treatment

[0032] Weigh 200Kg of resin white balls into a 2000L reaction kettle, add 700Kg ...

Embodiment 2

[0034] (1) Preparation of water phase

[0035] Add 1000Kg of pure water and 10 parts of polyvinyl alcohol into a 2000L reactor, and stir evenly;

[0036] (2) Preparation of oil phase

[0037] 100Kg of styrene, 10Kg of divinylbenzene, 0.1Kg of methyl trifluoromethacrylate (FPMMA), 0.1Kg of 4-vinylpyridine, 0.5Kg of benzoyl peroxide, and 10Kg of methyl isobutyl carbinol were stirred Uniform, get the oil phase;

[0038] (3) Suspension polymerization reaction

[0039] Add the oil phase solution prepared in step 2) to the reaction kettle equipped with the prepared water phase in step 1), add the oil phase solution prepared in step 2) to the reactor equipped with the prepared water phase in step 1) reaction kettle, and then reacted at 100°C for 10 hours. After the reaction, the reaction mixture was extracted with acetone and dried in vacuum to obtain polymer white balls;

[0040] (4) Functional treatment

[0041] Weigh 300Kg of resin white balls into a 1000L reaction kettle, ad...

Embodiment 3

[0043] (1) Preparation of water phase

[0044] Add 1000Kg of pure water and 20 parts of hydroxymethylcellulose into a 2000L reactor, and stir evenly;

[0045] (2) Preparation of oil phase

[0046] Stir 100Kg of styrene, 20Kg of divinylbenzene, 0.5Kg of methyl trifluoromethacrylate (FPMMA), 0.5Kg of 4-vinylpyridine, 2Kg of benzoyl peroxide, and 40Kg of methyl isobutyl carbinol , to obtain the oil phase;

[0047] (3) Suspension polymerization reaction

[0048] Add the oil phase solution prepared in step 2) to the reaction kettle equipped with the prepared water phase in step 1), add the oil phase solution prepared in step 2) to the reactor equipped with the prepared water phase in step 1) Reactor, and then reacted from 70 ° C for 15 hours. After the reaction, the reaction mixture was extracted with acetone and dried in vacuum to obtain polymer white balls;

[0049] (4) Functional treatment

[0050]Weigh 100Kg of resin white balls into a 2000L reaction kettle, add 400Kg of w...

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PUM

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Abstract

The invention discloses a preparation method of an adsorbent special for heparin sodium. In polymerization, slight FPMMA and 0.1-0.5 part of 4-vinyl pyridine are introduced to be used as comonomers, and methyl isobutyl carbinol is used as a pore-foaming agent, so as to improve the mechanical strength of the adsorbent.

Description

technical field [0001] The invention relates to a method for an adsorbent, in particular to a preparation method for a special adsorbent for heparin sodium. Background technique [0002] The emergence of heparin has created a miracle of life for many patients with cardiovascular and cerebrovascular diseases. At present, heparin is the most effective and clinically used anticoagulant drug in the world. It is mainly used in the treatment of cardiovascular and cerebrovascular diseases and hemodialysis. Among them, it is the only effective specific drug in hemodialysis treatment. Clinical application and research have shown that in addition to its anticoagulant effect, heparin also has a variety of other biological activities and clinical uses, including lowering blood lipids, anti-medial smooth muscle cell (SMC) proliferation, and promoting fibrinolysis. In addition, low-molecular-weight heparin is a large class of antithrombotic drugs that are further processed from heparin r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30C08B37/10
Inventor 王琪宇马骏
Owner JIANGSU WANBANG BIOPHARMLS
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