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Pharmaceutical composition for external use in acne treatment and preparation method thereof

A technology of externally used drugs and compositions, which is applied in the direction of drug combinations, pharmaceutical formulas, active ingredients of heterocyclic compounds, etc., and can solve problems such as large side effects, slow curative effect, and long cycle of traditional Chinese medicine

Active Publication Date: 2016-01-13
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of long period of use of traditional Chinese medicine, slow curative effect, and large side effects of Western medicine in the existing external pharmaceutical composition for treating acne, and to provide an external pharmaceutical composition for acne treatment and its preparation method

Method used

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  • Pharmaceutical composition for external use in acne treatment and preparation method thereof
  • Pharmaceutical composition for external use in acne treatment and preparation method thereof
  • Pharmaceutical composition for external use in acne treatment and preparation method thereof

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preparation example Construction

[0066] The present invention also provides a preparation method of an external pharmaceutical composition for acne treatment, comprising:

[0067] Step 1: extract natural plant essential oil, described natural plant essential oil preferably comprises the mixture of comfrey oil and evening primrose oil, the method for described evening primrose oil extraction is preferably supercritical CO 2 In the method of fluid extraction, the extraction pressure is preferably 33-35MPa, the extraction temperature is 30-45°C, the extraction time is 1.5-3 hours, and the flow rate is 2L / min; the extraction method of comfrey oil is preferably constant temperature electric heating Heating and extraction, preferably using olive oil as a solvent, the ratio of solid to liquid is preferably 1:6, the extraction temperature is 60°C, and the extraction time is 3h;

[0068] Step 2: Put B vitamins and antibiotics into the tissue masher in turn, first turn on the slow gear and gradually turn on the fast ge...

Embodiment 1

[0071] Extraction method of evening primrose oil: Take dried primrose seeds, crush them, pass through a 50-mesh sieve, and use supercritical CO 2 Fluid extraction method to extract volatile components, extraction conditions: extraction pressure 35Pa, extraction temperature 45 ℃, extraction time 1.5 hours, flow rate 2L / min;

[0072] The extraction method of comfrey oil is heated by a constant temperature electric heating mantle, olive oil is used as a solvent, the ratio of solid to liquid is preferably 1:6, the extraction temperature is 60°C, and the extraction time is 3 hours;

[0073] 20 servings of vitamin B 12 , 5 copies of B 6 , 10 copies of B 2 , 10 copies of B 1 and 10 parts of erythromycin into the tissue masher in turn, first turn on the slow gear and gradually turn to the fast gear, run for 3 minutes, turn off the instrument and let it stand for 5 minutes, add 10 parts of vitamin E, 10 parts of comfrey oil, 10 parts of Evening primrose oil, running for 3 minutes, ...

Embodiment 2

[0075] Extraction method of evening primrose oil: take dried primrose seeds, crush them, pass through a 60-mesh sieve, and use supercritical CO 2 Fluid extraction method extracts volatile components, extraction conditions: extraction pressure is 30MPa, extraction temperature is 30°C, extraction time is 2 hours, flow rate is 2L / min;

[0076] The extraction method of comfrey oil is heated by a constant temperature electric heating mantle, olive oil is used as a solvent, the ratio of solid to liquid is preferably 1:6, the extraction temperature is 60°C, and the extraction time is 3 hours;

[0077] 25 servings of vitamin B 12 , 5 copies of B 6 , 15 copies of B 2 , 20 copies of B 1 and 30 parts of streptomycin were put into the tissue masher in turn, first turn on the slow gear and gradually turn to the fast gear, run for 3 minutes, turn off the instrument and let it stand for 5 minutes, add 20 parts of vitamin E, 30 parts of comfrey oil, 25 parts of Evening primrose oil, runni...

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Abstract

The invention provides a pharmaceutical composition for external use in acne treatment and a preparation method thereof, belongs to the technical field of pharmaceutical compositions and solves the problem that with an existing pharmaceutical composition for acne treatment, traditional Chinese medicine treatment consumes a long period of time and takes effects slowly, while western medicine treatment causes major side effects. The pharmaceutical composition comprises, by weight: 20-55 parts of natural plant essences, 45-75 parts of vitamins B, 10-20 parts of vitamin E, and 10-30 parts of antibiotics. The joint use of traditional Chinese medicine and western medicine enables mutual coordination among pharmaceuticals, thus enhancing the pharmaceutical effect without any side effect; the composition is capable of inhibiting bacteria, diminishing inflammation, promoting wound healing, inhibiting scar and reducing pigment deposition, and is significantly effective in treating acnes.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions, and in particular relates to an external pharmaceutical composition for treating acne and a preparation method thereof. Background technique [0002] The occurrence of acne is the result of the interaction of many factors, and its pathogenesis is mainly related to factors such as the level of sex hormones, the massive secretion of sebaceous glands, the proliferation of Propionibacterium acnes, abnormal keratinization of the pilosebaceous ducts, and inflammation. Environmental factors and genetic factors interact and promote each other to induce and aggravate acne. [0003] In the process of acne treatment, in addition to paying attention to drug treatment, patients with family history of acne and severe acne should avoid the following risk factors (such as eating spicy food, high-fat food, animal oil, egg products, fish products, contact reflex line, sunlight exposure, etc.)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/30A61P17/02A61P17/10A61K31/4415A61K31/51A61K31/525A61K31/7036A61K31/7048A61K31/714
Inventor 王艳
Owner JILIN UNIV
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