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Decoction-free extraction process for precious Chinese herbal medicines

An extraction process and technology of traditional Chinese medicinal materials, which are applied in plant raw materials, plant/algae/fungus/moss ingredients, pharmaceutical formulations, etc., can solve the problems of low controllability of cell wall-breaking treatment, ensure blood drug concentration and reduce loss. , the effect of improving the absorption rate

Inactive Publication Date: 2016-01-13
HENAN XINGZHI PATENT SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the controllability of the traditional cell wall breaking technology in this scheme to the cell wall breaking treatment is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The decoction-free extraction process of the precious plant Chinese medicinal material Cordyceps sinensis, the steps are as follows:

[0029] 1) Washing, drying and crushing Cordyceps sinensis to 20 mesh;

[0030] 2) Using supercritical CO 2 The extraction process removes the heavy metals in the Cordyceps sinensis granules obtained in step 1): the specific process conditions are as follows, the extraction temperature is 25°C, the pressure is 15MPa, the time is 15 minutes, CO 2 The flow rate is 25 liters / hour, ethanol is 3wt%, EDCI is 2wt%, and the content of heavy metals in Cordyceps sinensis granules is reduced from 2% to 0.03%;

[0031] 3) Baking the Cordyceps sinensis granules from which heavy metals were removed in step 2: 45°C, 50 minutes, moisture content 0.5wt%;

[0032] 4) Superfinely pulverize the baked Cordyceps sinensis particles obtained in step 3) with a particle size of 0.35 μm;

[0033] 5) Wall breaking treatment: add 3wt% sodium gelatate, 5wt% cyclode...

Embodiment 2

[0035] The decoction-free extraction process of the precious plant Chinese medicinal material wild ginseng, the steps are as follows:

[0036] 1) Wash, dry and crush wild wild ginseng to 30 mesh;

[0037] 2) Using supercritical CO 2 The extraction process removes the heavy metals in the wild ginseng particles obtained in step 1): the specific process conditions are as follows, the temperature is 50°C, the pressure is 25MPa, the extraction time is 35 minutes, CO 2 The flow rate is 30 liters / hour, ethanol 10wt%, DCC 5wt%, and the heavy metal content in wild ginseng granules is reduced from 2% to 0.03%;

[0038] 3) Baking the wild wild ginseng granules from which heavy metals have been removed in step 2): 50°C, 60 minutes, moisture content 0.3wt%;

[0039] 4) Superfinely pulverize the baked wild ginseng particles obtained in step 3) with a particle size of 0.75 μm;

[0040] 5) Wall breaking treatment: add the wild wild ginseng granules obtained in step 4) to the auxiliary mate...

Embodiment 3

[0042] The non-decoction extraction process of the precious plant Chinese medicinal material American ginseng, the steps are as follows:

[0043] 1) Wash, dry and crush American ginseng to 25 mesh;

[0044] 2) Using supercritical CO 2 The extraction process removes the heavy metals in the American ginseng granules obtained in step 1): the specific process conditions are as follows, the temperature is 45°C, the pressure is 22MPa, the extraction time is 30 minutes, CO 2 The flow rate is 28 liters per hour, ethanol is 8wt%, DCC is 4wt%, and the content of heavy metals in American ginseng granules is reduced from 4% to 0.02%;

[0045] 3) Baking American ginseng granules from which heavy metals were removed in step 2: 48°C, 55 minutes, moisture content 0.4wt%;

[0046] 4) Superfinely pulverize the baked American ginseng particles in step 3) with a particle size of 0.60 μm;

[0047]5) Wall breaking treatment: add the American ginseng granules obtained in step 4) to the auxiliary ...

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Abstract

The invention discloses a decoction-free extraction process for precious Chinese herbal medicines. The process includes the steps: 1) cleaning, drying and grinding the Chinese herbal medicines into 20-30-mesh particles; 2) adopting a supercritical CO2 extraction process for removing heavy metals from the Chinese herbal medicine particles obtained at the step 1); 3) roasting the Chinese herbal medicine particles with the heavy metals removed at the step 2) for 50-60min at the temperature of 45-50 DEG C until the water content is 0.3-0.5wt%; 4) subjecting the Chinese herbal medicine particles roasted at the step 3) to ultrafine pulverization until the particle size is 0.35-0.75micrometer; 5) performing wall-breaking treatment, namely adding auxiliary materials into the Chinese herbal medicine particles obtained at the step 4), and extracting active ingredients by application of a low-temperature micro-nano wall-breaking technique. By effective rejection of heavy metal pollution, pharmacological functions of the Chinese herbal medicines can be improved, and side effects are reduced; by application of the cell wall breaking technique for powder processing, biological activity and bioavailability of the Chinese herbal medicines can be improved.

Description

technical field [0001] The invention relates to the technical field of biopharmaceutical / health product production, and mainly relates to a decoction-free extraction process of precious plant Chinese medicinal materials. Background technique [0002] Chinese herbal medicines are special products that people use to prevent and treat diseases, and they should first of all be non-toxic to the human body. Once Chinese herbal medicines are polluted by pesticides and heavy metals, they may pose a potential threat to the human body, especially the sick. [0003] Usually the detoxification function is poor, and the harm caused is greater than that of ordinary people. This will not only fail to cure the disease, but aggravate and delay the treatment of the patient. [0004] In recent years, the annual sales of the world's herbal medicine market has reached 40 billion US dollars, and it is increasing at a rate of 10% per year. At present, it only accounts for about 1% of the world's...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61K36/258A61K36/074A61K35/413A61K36/835A61K36/889A61K36/896A61K36/898A61K36/8988A61K31/045A61K35/648A61K35/62
Inventor 马新攀
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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