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Monomolecular-layer probe for detecting cyanide ion and preparation and application methods thereof

A monomolecular probe, monomolecular layer technology, applied in material analysis by observing the influence of chemical indicators, and analysis by chemical reaction of materials, etc., can solve the complex preparation and characterization process, and the insoluble organic compounds. or insoluble, difficult to operate and other problems, to achieve the effect of low cost, high sensitivity and high specificity

Active Publication Date: 2015-12-23
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many detections in the molecular probe method are realized by the interaction between organic molecules with specific structures and target detection substances, but organic compounds are often insoluble or insoluble in water. If you want to detect in aqueous solution, you must prepare water-soluble Probes, or through the method of forming nanostructures, usually the preparation and characterization process is complicated and difficult to operate

Method used

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  • Monomolecular-layer probe for detecting cyanide ion and preparation and application methods thereof
  • Monomolecular-layer probe for detecting cyanide ion and preparation and application methods thereof
  • Monomolecular-layer probe for detecting cyanide ion and preparation and application methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 metal oxide is NiO

[0032] 1) Scrape-coat the nickel chloride slurry on the substrate (transparent glass), and after the solvent evaporates, sinter at 450°C for 30 minutes to obtain a NiO film;

[0033] 2) Soak 11 pieces of glass sheets with NiO films dried in step 1) into an ethanol solution containing 0.1mmol / LP1, soak for 1 minute at a temperature of 21-25°C, take them out, wash them with chloroform, blow dry, to obtain a NiO thin film adsorbed with a certain amount of probe molecule P1;

[0034] 3) Weigh 0.42mgNaF, 0.58mgNaCl, 1.19mgKBr, 1.66mgKI, 0.78mgNa 2 S, 1.42mgNa 2 HPO 4 , 1.42mgNa 2 SO 4 , 1.06mgNa 2 CO 3 , 0.82mgCH 3 COONa, 2.68 mg (C 4 h 9 ) 4 N + CN - Dissolve in 1mL mixed solution (ethanol:PBS=2:3) to obtain a concentration of 10 -2 mol / L solution, and then take 100μL to dilute to 10mL for later use;

[0035] 4) Immerse the NiO film obtained in step 2) and adsorbed the monomolecular layer P1 in various anion solutions obtaine...

Embodiment 2

[0041] Embodiment 2 metal oxide is TiO 2

[0042] 1) TiO with sizes of 20nm, 200nm, and 400nm were respectively 2 The nanoparticle slurry is drip-coated on the substrate (transparent conductive glass), and after the solvent is volatilized, it is sintered at 450°C for 30 minutes to obtain TiO 2 film;

[0043] 2) The TiO with a size of 20nm prepared in step 1) 2 Take 11 pieces of the film and soak them in 0.1mM P1 ethanol solution, soak them for 1 minute at room temperature, take them out, wash them with chloroform, and dry them to get TiO2 adsorbed with a certain amount of probe molecules P1. 2 film sheet;

[0044] 3) Weigh 0.42mgNaF, 0.58mgNaCl, 1.19mgKBr, 1.66mgKI, 0.78mgNa 2 S, 1.42mgNa 2 HPO 4 , 1.42mgNa 2 SO 4 , 1.06mgNa 2 CO 3 , 0.82mgCH 3 COONa, 2.68 mg (C 4 h 9 ) 4 N + CN - Dissolve in 1mL mixed solution (ethanol:PBS=2:3) to obtain a concentration of 10 -2 mol / L solution, and then take 100 μL to dilute to 10mL for later use; 2 Thin film is immersed in...

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Abstract

The invention relates to a monomolecular-layer probe for detecting cyanide ion and preparation and application methods thereof. The probe of the invention is P1 for adsorbing a monomolecular layer onto the surface of a metallic oxide thin film. P1 is a conjugated molecule based on triphenylamine and a dicyanovinyl group. Triphenylamine is used as an electron donor unit, and the dicyanovinyl group is used as an electron acceptor unit and simultaneously is a detection group. In addition, triphenylamine is also connected to a carboxyl group used for adsorbing P1 onto the metallic oxide thin film. As P1 is adsorbed on the metallic oxide thin film, the thin film is dark red. The probe is used to detect trace amount of cyanide ion in an aqueous solution, and the detection group reacts with cyanide ion such that dark red of the thin film remarkably fades. The detection method has high specificity and can rapidly respond to cyanide ion (10<8> mol / L) in an extremely dilute solution. Limit of detection (LOD) of cyanide ion by the monomolecular-layer probe is 2.99nmol / L. Thus, the monomolecular-layer probe is fast and convenient and has high sensitivity in detection of a solution phase in comparison with a conventional probe molecule.

Description

technical field [0001] The invention belongs to the technical field of chemical analysis and detection, and in particular relates to a monomolecular layer probe for detecting cyanide ions and a preparation and application method thereof. Background technique [0002] Cyanide is an important raw material for synthetic resins, medicines, pesticides, insecticides, fertilizers, etc., and is also an important reagent for gold plating and metallurgy. However, cyanide is a highly toxic substance, and its lethal dose to humans is very small. In addition to direct ingestion, its vapor and dust can also enter the human body through the respiratory tract or digestive tract, and even penetrate into the skin. Combining with valent iron, the cells cannot use oxygen, lose the function of transferring oxygen, and make the body hypoxic, causing poisoning and even death. The World Health Organization stipulates that the maximum allowable content of cyanide ion in drinking water is 0.07mg / L (...

Claims

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Application Information

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IPC IPC(8): G01N21/78
Inventor 朱琳娜赵尚碧吴飞
Owner SOUTHWEST UNIVERSITY
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