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Compound gel moisturizing eye drops

A gel and moistening technology, applied in the field of medicine, can solve problems such as organic changes of the eye, physiological toxicity, and ineffective curative effect, and achieve the effects of improving compliance, high bioavailability, and remarkable curative effect

Inactive Publication Date: 2015-12-23
吕欢
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Common eye drops to prevent eye fatigue include pearl eye drops, naphthalene eye drops, taurine, etc. Although they have a certain effect on relieving eye fatigue, long-term use is prone to drug dependence, and it is easy to cause local or systemic symptoms. Physiological toxicity and other problems, the curative effect will become less and less obvious, more serious will lead to organic changes in the eyes, resulting in serious consequences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A compound gel moisturizing eye solution, comprising the following components: 3-7 parts of dextran, 2-4 parts of isotrehalose (β, β), 1.5-2 parts of D-mannose, and 0.2-0.5 parts of sodium cromolyn , 0.03-0.08 parts of leptin, 0.01-0.015 parts of isoproterenol, 0.006-0.012 parts of chlorobutanol, 15-25 parts of gel matrix, 0.005-0.01 parts of adhesive, 0.02-0.05 parts of emulsifier, 0.01- 0.1 part of vitamin additive; in addition, it also includes sodium chloride, an isotonic regulator, and the dosage is 3% to 5% w / v.

[0027] Wherein, the gel matrix is ​​a water-based gel, preferably poloxamer. The water-based gel is a good viscosifier and a matrix of an excellent drug delivery system. The retention time is long and the bioavailability is improved; the adhesive is a plasminogen activator, which shows an excellent healing effect on eye mucosal injuries; the emulsifier is polysorbate 80, which has a good emulsifying effect , no harm to the eyes; the above-mentioned vita...

Embodiment 2

[0037] A compound gel moisturizing eye solution, comprising the following components: 3-7 parts of dextran, 2-4 parts of isotrehalose (β, β), 1.5-2 parts of D-mannose, and 0.2-0.5 parts of sodium cromolyn , 0.03-0.08 parts of leptin, 0.01-0.015 parts of isoproterenol, 0.006-0.012 parts of chlorobutanol, 15-25 parts of gel matrix, 0.005-0.01 parts of adhesive, 0.02-0.05 parts of emulsifier, 0.01- 0.1 part of vitamin additive; in addition, it also includes sorbitol, an isotonic regulator, with a dosage of 3% to 5% w / v.

[0038] Wherein, the gel matrix is ​​a water-based gel, preferably sodium hyaluronate. The water-based gel is a good viscosifier and a matrix of an excellent drug delivery system. The retention time is long and the bioavailability is improved; the adhesive is a plasminogen activator, which shows an excellent healing effect on eye mucosal injuries; the emulsifier is polysorbate 80, which has a good emulsifying effect , no harm to the eyes; the above-mentioned vit...

Embodiment 3

[0048] A compound gel moisturizing eye solution, comprising the following components: 3-7 parts of dextran, 2-4 parts of isotrehalose (β, β), 1.5-2 parts of D-mannose, and 0.2-0.5 parts of sodium cromolyn , 0.03-0.08 parts of leptin, 0.01-0.015 parts of isoproterenol, 0.006-0.012 parts of chlorobutanol, 15-25 parts of gel matrix, 0.005-0.01 parts of adhesive, 0.02-0.05 parts of emulsifier, 0.01- 0.1 parts of vitamin additives; in addition, glycerol, an isotonic regulator, is used in an amount of 3% to 5% w / v.

[0049] Wherein, the gel matrix is ​​a water-based gel, preferably sodium hyaluronate. The water-based gel is a good viscosifier and a matrix of an excellent drug delivery system. The retention time is long and the bioavailability is improved; the adhesive is a plasminogen activator, which shows an excellent healing effect on eye mucosal injuries; the emulsifier is polysorbate 80, which has a good emulsifying effect , no harm to the eyes; the above-mentioned vitamin add...

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PUM

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Abstract

Disclosed compound gel moisturizing eye drops comprises the following compositions: 3-7 parts of dextran, 2-4 parts of isotrehalose (belta, belta), 1.5-2 parts of D-mannose, 0.2-0.5 part of sodium cromoglycate, 0.03-0.08 part of leptin, 0.01-0.015 part of isoproterenol, 0.006-0.012 part of chlorobutanol, 15-25 part of gel matrix, 0.005-0.01 part of an adhesive, 0.02-0.05 part of an emulsifier, and 0.01-0.1 part of a vitamin additive. The compound gel moisturizing eye drops are free of stimulation, does not cause anaphylactic reaction, helps to increase eye water wettability and prolong the retention time of the eye drops on eye surface, tear film or other positions, and are good in compatibility with eyeball tissue and high in bioavailability, the dosing frequency is reduced, the medicine economic benefit is improved, and the compound gel moisturizing eye drops possess special water-retention effect and substantial curative effect on ophthalmic diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound gel moisturizing eye lotion. Background technique [0002] With the acceleration of the pace of modern cultural life, work and study are overly stressful, and the psychological quality is too heavy. In addition, the unclean pollution of the ecological environment, the impact of air quality such as air dust and smog, and the mental stress, improper coordination between work and rest, long-term Excessive use of the eyes leads to insufficient recuperation and rest of the eyes. At the same time, there are more and more eye lesions induced by many factors. Different degrees of lesions can lead to decreased vision, forming myopia, amblyopia, visual fatigue or eye fatigue, Symptoms such as pain in the eye frame can cause blurred vision, vertigo or even blindness in severe cases. [0003] Among them, eye fatigue is a common disease in ophthalmology. It causes dry eyes, eye a...

Claims

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Application Information

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IPC IPC(8): A61K31/721A61K9/08A61P27/02A61P27/10A61K31/4412A61K31/352
Inventor 吕欢
Owner 吕欢
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