Cefdinir dispersible tablet and preparation method thereof

Abstract

The invention discloses a cefdinir dispersible tablet and a preparation method thereof. The cefdinir dispersible tablet is prepared from, by weight, 50 parts of cefdinir, 15-75 parts of microcrystalline cellulose, 15-75 parts of mannitol, 1.5-12 parts of polyvinylpolypyrrolidone, 1.5-15 parts of aspartame, 0.375-7.5 parts of silicon dioxide and 0.375-7.5 parts of magnesium stearate. The formula of the cefdinir dispersible tablet is optimized, the raw materials are prevented from being micronized in the direct powder compression preparation process, and process operation is simplified; meanwhile, cefdinir and auxiliary materials do not need to be separately screened, the yield of products is increased, the cefdinir dispersible tablet is suitable for expanded production, after expanded production, loose tablets, cracking tablets, sticking and the like are avoided, the dissolution rate of prepared medicine is high, the impurity content is low, the tablet difference is low, the yield is high, and the quality stability and yield of the medicine are guaranteed.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a cefdinir dispersible tablet and a preparation method thereof. Background technique [0002] The chemical name of cefdinir (cefdinir, CASNO.: 91832-40-5) is: (6R, 7R)-7-[(Z)-2-(2-amino-4thiazolyl)-2-hydroxyimino -Acetamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. [0003] Its structural formula is: [0004] [0005] Cefdinir is an oral third-generation cephalosporin, which has the advantages of broad antibacterial spectrum and low toxicity. It can be used to treat tonsillitis, sinusitis, otitis media, acute bronchitis, pneumonia, abdominal cavity, and urogenital tract infection. It is widely used in infectious diseases caused by sensitive bacteria such as internal medicine, surgery, dermatology, obstetrics and gynecology, and urology. [0006] The existing application numbers are CN201410220481.7, CN201310194902.9, CN201310470821.7 an...

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Problems solved by technology

However, the cefdinir bulk drug has poor water solubility, is prone to static electricity, and has poor fluidity. It is unstable to conditions such as humidity, heat, and light, and the impurity content seriously affects the safety and effectiveness of the product.

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