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Functional nano particle composite microsphere, preparation and applications thereof

A nanoparticle and composite microsphere technology, which is applied in microsphere preparation, microcapsule preparation, instruments, etc., can solve the problem of non-specific adsorption of nanoparticle composite microspheres that has not yet been seen.

Active Publication Date: 2015-12-09
ZHEJIANG ORIENT GENE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there have been no reports on non-specific adsorption on the surface of nanoparticle composite microspheres

Method used

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  • Functional nano particle composite microsphere, preparation and applications thereof
  • Functional nano particle composite microsphere, preparation and applications thereof
  • Functional nano particle composite microsphere, preparation and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of PEG graft polymer (one)

[0025] Dissolve 1 g of polystyrene maleic anhydride copolymer (PSMA) and 2 g of polyethylene glycol monomethyl ether (mPEG1000) with a molecular weight of 1000 in 20 ml of dimethylformamide (DMF), and add 100 mg of catalyst p-toluenesulfonic acid , dissolved at room temperature for 2 hours, mixed evenly, and heated to 100 degrees Celsius under nitrogen protection for 12 hours. After the reaction was completed, anhydrous ether was added to precipitate the obtained polymer PSMA-PEG, and the polymer was freeze-dried after repeated centrifugation and washing for three times.

Embodiment 2

[0026] Embodiment 2: the preparation of PEG graft polymer (two)

[0027] Dissolve 1 g of polystyrene acrylic acid copolymer and 5 g of carboxyl-terminated polyethylene glycol monomethyl ether (mPEG-COOH) with a molecular weight of 5000 in 30 ml of chloroform, add a few drops of concentrated sulfuric acid in N 2 Heating, condensing, and reflux for 12 hours under protective conditions, adding anhydrous diethyl ether to precipitate the polymer after the reaction was completed, repeated centrifugal washing three times, and freeze-drying the polymer for use.

Embodiment 3

[0028] Embodiment 3: the preparation of PEG graft polymer (three)

[0029] Maleic anhydride / 1-octadecene alternating copolymer (PMAO) and 10 g molecular weight of 2000 one-terminal amino-terminated PEG (mPEG-NH 2 ) was dissolved in 30ml chloroform, and after stirring for 24 hours, absolute ethanol was added to precipitate the polymer, and unreacted PEG molecules were removed, and the polymer was freeze-dried after repeated centrifugal washing for three times.

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Abstract

The invention discloses a functional nano particle composite microsphere. The functional nano particle composite microsphere is a functional nano particle composite PEG microsphere, which comprises functional nano particles and polymer containing a PEG chain segment; wherein the functional nano particle composite PEG microsphere has an average particle size of 0.1 to 1000 [mu]m, and the particle size distribution variable coefficient is less than 10%. According to the invention, functional nano particles and PEG chain segment grafted polymer are made into composite microspheres with a uniform particle size, the PEG chain segment can effectively inhibit the non-specific adsorption; and thus the provided composite microsphere has a wide application prospect in the fields of biological detection and biomedicine.

Description

technical field [0001] The invention relates to the field of preparation and application of micro-nano materials, in particular to functional nanoparticle composite microspheres and applications thereof. Background technique [0002] Functional nanoparticle composite microsphere refers to a functional composite microsphere obtained by combining functional nanoparticles and microspheres by a certain method. At present, nanoparticles prepared by various methods have various special optical, electrical, magnetic and biological characteristics, so these characteristics are often endowed to the microsphere itself after being combined with the microsphere. Microspheres also provide support and effective protection for these nanoparticles. At the same time, the chemical and physical properties of the microspheres themselves, such as light sensitivity, pH responsiveness, temperature sensitivity, adsorption properties, and surface active functional groups, also provide possibilities...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02G01N33/543
Inventor 李万万冷远逵武卫杰孙康
Owner ZHEJIANG ORIENT GENE BIOTECH
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