Dressing and preparation method thereof

A compound and inorganic silicon technology, applied in the field of medical materials, can solve the problems of difficult protein stability, high price, limited sources, etc., and achieve the effect of preventing secondary bacterial infection, good biological stability and safety.

Active Publication Date: 2015-11-25
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this kind of fibronectin can promote the attachment of human cells in theory, in practical application, such as extracting such protein from human plasma, the source is limited and the price is expensive, so it is difficult to implement clinically, such as in vitro If such protein is obtained through genetic engineering, the protein synthesized by the gene will not have the biological activity similar to the natural protein of human body
In addition, no matter whether it is natural or gene-synthesized protein, it is not suitable for disinfection and it is easy to cause hypersensitivity in the human body. The stability of protein is difficult to be preserved in various environments in production, storage, transportation, sales and clinical practice. The theory that bioactive protein is used as an active ingredient in commonly used external medicine does not have clinical practical value

Method used

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  • Dressing and preparation method thereof
  • Dressing and preparation method thereof
  • Dressing and preparation method thereof

Examples

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Effect test

preparation example Construction

[0033] The present invention also provides a preparation method of a dressing, comprising: A) printing an inorganic silicon compound and / or an inorganic calcium compound on the surface of gauze by using a 3D printer to obtain a dressing.

[0034] Wherein, the inorganic silicon compound and the inorganic calcium compound are the same as those described above, and will not be repeated here.

[0035] According to the invention, the inorganic silicon compound and / or the inorganic calcium compound are preferably ground, sieved and autoclaved. The milling is preferably done with a mill, more preferably an orbital self-rolling mill; the milling time is preferably 1 to 3 days; the sieving is preferably filtered with a precision screen.

[0036] Then use a 3D printer to print on the surface of the gauze to obtain a dressing. The gauze can be any gauze known to those skilled in the art, and there is no special limitation. In the present invention, the gauze is preferably sterilized wit...

Embodiment 1

[0041] 1.1 Mix 60 parts by weight of silicon oxide with 40 parts by weight of calcium oxide, put it in an orbital self-rolling mill and grind it for 1 day, then filter through a precision screen to select a diameter of 100nm to 100μm, after steam autoclaving, get complex.

[0042] 1.2 Put the compound obtained in 1.1 in the nozzle of a 3D printer, and quantitatively jet-print the compound onto the surface of gauze sterilized by ethylene oxide to form a uniform array structure at a printing flow rate of 0.3 g / min to obtain a dressing.

[0043] The dressing that obtains in embodiment 1 promotes the clinical effect of quick healing of human skin wound:

[0044] The patient was a 16-year-old girl who fell and injured her left knee by the swimming pool. The area of ​​the skin contusion was about 3×6 cm2, and the depth reached the deep layer of the dermis, with obvious exudation on the surface. Immediately after the wound, the dressing obtained in Example 1 was applied to the wound...

Embodiment 2

[0046] Epithelial cells (taken from normal human skin) are cultured and grown in the solution added with inorganic silicon compound and / or calcium compound to form the experimental group, and the control group does not add the compound. During the culture process, the fresh culture medium containing the same specific chemical concentration was replaced every 3 days, and the cell proliferation test was done on the 12th and 20th days of culture; The total number of grown cells was counted, and the proliferation value of epithelial cells was calculated based on the number of cells attached to the culture dish in the first 24 hours of culture.

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Abstract

The invention provides dressing and a preparation method thereof. The dressing comprises gauze and inorganic silicon compound and / or inorganic calcium compound attached to the gauze. Compared with the prior art, the gauze is taken as a carrier, and the dressing has the effect of absorbing seepage; inorganic silicon compound and / or inorganic calcium compound are / is taken as the externally applied agent, and good biological stability and safety are obtained, and silicon element and / or calcium element have / has the biological induction property of actively inducing proliferation, differentiation and migration of the human-body epithelial cells, as well as the anti-inflammatory property of neutralizing the pH value of a wound surface, and can induce the healing of the epithelium wound and prevent the secondary bacterial infection; therefore, the dressing can be used for treating various skin wounds caused by large area of burns, chemical burn, bedsore and human body surface anabrosis as well as various kin wounds caused by incised injury, fall injury, contused wound and scald injury.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a dressing and a preparation method thereof. Background technique [0002] Skin is one of the largest and most important organs in the human body, and plays a very important role in maintaining the stability of the internal environment and preventing microbial invasion. Skin damage caused by trauma, burns, ulcers, etc. will cause a series of problems such as infection, increased metabolism, excessive loss of water and protein, and severe cases may be life-threatening. Therefore, people have been looking for ways to promote wound repair. [0003] As a wound covering, dressings can temporarily protect the wound and prevent infection, provide a favorable microenvironment for wound healing, and assist wound healing. For a long time, traditional gauze dressings have been used for the longest time and have the highest market share. Although traditional gauze dressings can i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61K33/42A61K33/08A61K33/00A61P17/02
Inventor 陈海佳王一飞葛啸虎黄幸马岩岩
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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