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Anal fistula thread of three-dimensional composite structure and preparation method of anal fistula thread

A three-dimensional composite, anal fistula technology, applied in the fields of medical science, textiles and papermaking, surgery, etc., can solve the problems of increasing patient pain, increasing the chance of infection, easily causing anal incontinence, etc., to shorten the operation time and frequency, reduce difficulty and side effects , easy to learn and promote

Active Publication Date: 2015-11-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of conventional materials for drainage is not conducive to promoting fistula healing, and it is easy to cause the risk of adverse sequelae such as anal incontinence, which increases the pain of patients
Systemic administration such as intravenous injection and other treatment options, the drug is metabolized by the kidneys and separated layer by layer, and the effective concentration of the actual perianal patient part is very low, and the effect is not ideal; and systemic administration will lead to allergies, increase the chance of infection, and increase the risk of infection. risk of cancer
Repeated injections may also lead to the production of antibodies and decreased efficacy

Method used

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  • Anal fistula thread of three-dimensional composite structure and preparation method of anal fistula thread
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  • Anal fistula thread of three-dimensional composite structure and preparation method of anal fistula thread

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: A three-dimensional composite structure anal fistula thread. The anal fistula line has a three-layer structure, which are:

[0035] The innermost layer 1 is more than two strands of hollow filament braided wire that can provide good flexibility and mechanical strength, which is convenient for traction and position correction during implantation.

[0036]The middle layer 2 is a superfine fiber-based structural layer, and the fibers in this layer have the characteristics of sea-island cross-section, moderate fluffiness, good fiber orientation, and orderly arrangement. The middle layer is a collection of fiber bundles, and the index of bulkiness is represented by fiber filling density, and the filling density of superfine fibers in the middle layer is 50-80±2kg / m 3 , If the filling density is too high, the drainage resistance will be large, and the drainage effect cannot be achieved; if the filling density is too small, the middle layer will be loose, and th...

Embodiment 2

[0039] A kind of three-dimensional composite structure anal fistula thread, which adopts braiding method to prepare the inner (core) layer of the anal fistula thread: in this embodiment, the inner layer of the anal fistula thread adopts two or more strands of braided thread, which is a hollow fiber filament with a circular cross section. It is woven by a vertical spindle type circular knitting machine. The weaving process is as follows: 8-24 spindle vertical knitting machines are used, respectively according to the three structures of diamond weaving (1 / 1 interweaving), regular weaving (2 / 2 interweaving) and Hercules (3 / 3 interweaving). The braiding angle is 45-60°. Then, place the braided wire in a vacuum oven at 80±2°C for heat setting for 30 minutes. The hollow fiber filament has a hollowness of 18-36%, a filament linear density of 100-200dtex, and the raw material is L-polylactide (PLLA). The tensile strength of the hollow fiber filament braided wire obtained in this emb...

Embodiment 3

[0043] A three-dimensional composite structure anal fistula thread, the inner (core) layer of the anal fistula thread is prepared by the method of parallel arrangement of filaments, in this embodiment, the inner layer of the anal fistula thread adopts two or more parallel arrangement threads, which are hollow fibers with a circular cross section filament. Then, soak the hollow fiber filaments in 5-20% silk fibroin aqueous solution for 3-10s, put them in a vacuum oven at 80±2°C for heat setting for 30-60 minutes, and repeat the above operation three times. The hollow fiber filament has a hollowness of 18-36%, a filament linear density of 100-200dtex, and a raw material of polydioxanone (PDO). The tensile strength of the hollow fiber filament braided wire obtained in this embodiment is greater than 400N / mm 2 , The breaking strength is greater than 600MPa, the melting temperature is higher than 90°C, and the breaking elongation is less than 40%. Other options for hollow fiber f...

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Abstract

The invention discloses an anal fistula thread of a three-dimensional composite structure and a preparation method of the anal fistula thread. The anal fistula thread is of a structure having three layers, wherein the inner layer includes two or more hollow filament braided threads; the middle layer is a superfine fiber-based structural layer that superfine fiber filling density is 50-800kg / m3, and the fibers in the layer have island section, moderate bulkiness, good orientation degree and order distribution; and the outer layer is a silk fibroin based drug-loaded nanofiber film which is 50-200nm in fiber fineness and 800-1300um in film thickness; drugs are added to the layer; and after the anal fistula thread is implanted in the affected part of a human body, the layer can be directly contacted with pathological tissues of anal fistula and can release drugs. The anal fistula thread of the three-dimensional composite structure provided by the invention is a novel biomedical textile material for treating anal fistula in Crohn's disease; the material has a drainage function; and meanwhile, the material has a drug sustained release and is capable of promoting healing of anal fistula so as to achieve an effect of treating Crohn's disease.

Description

technical field [0001] The invention relates to a special device and a preparation method in the field of biomedical textiles, in particular to a three-dimensional composite structure anal fistula thread and a preparation method thereof. Background technique [0002] Crohn's disease (Crohn's disease, CD) is a chronic inflammatory disease of the intestinal tract. The incidence rate in the United States is 100 / 100,000 people, and the incidence rate in my country has increased in recent years. Anal fistula is one of the common complications of Crohn's disease, and its treatment is complicated. It mainly depends on adequate surgical drainage and requires repeated operations. A small number of patients with Crohn's disease combined with anal fistula have a long treatment cycle and a high recurrence rate, and may need to undergo permanent colostomy, which seriously affects the quality of life of the patients. Oral or repeated anal fistula will cause serious economic and mental bu...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/04A61L31/06D02G3/04D02G3/44
Inventor 李刚韩植芬刘磊郅敏王晓沁
Owner SUZHOU UNIV
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