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Application of rubus suavissimus water-soluble polysaccharide in protection of liver and activation of acetaldehyde dehydrogenase

A technology of Rubus oleifera and water-soluble polysaccharide, applied in the directions of monosaccharides, sugar derivatives, sugar derivatives, etc., can solve the problems of storage, damage, fatty acid liver cell secretion dysfunction, etc., and reduce oxidative stress damage , good liver, liver protection effect

Inactive Publication Date: 2015-11-11
XIANGTAN UNIV
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  • Summary
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Problems solved by technology

Secondly, acetaldehyde can also damage the mitochondria and microtubules of most hepatocytes, thereby causing fatty acid oxidation and hepatocyte secretion dysfunction, resulting in fatty acid accumulation and secretory protein retention in hepatocytes

Method used

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  • Application of rubus suavissimus water-soluble polysaccharide in protection of liver and activation of acetaldehyde dehydrogenase
  • Application of rubus suavissimus water-soluble polysaccharide in protection of liver and activation of acetaldehyde dehydrogenase
  • Application of rubus suavissimus water-soluble polysaccharide in protection of liver and activation of acetaldehyde dehydrogenase

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Experimental program
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Embodiment

[0028] 1. Extraction of water-soluble polysaccharides from Rubus sweet leaf of Rosaceae Rubus

[0029] After pulverizing the dried leaves of Rubus sweet leaf, extract with ethanol with a volume fraction of 80% at 70°C for 90 minutes, suction filter, discard the filtrate, and extract the filter residue twice with deionized water at 60°C for 120 minutes each time, and suction filter after cooling. The two filtrates were combined, concentrated by distillation under reduced pressure at 55°C, added three times the volume of absolute ethanol to precipitate, and stood overnight at 4°C; the precipitate a was collected by suction filtration, weighed, and the precipitate a was alternately washed 3 times with acetone, ether, and ethanol. Dissolve in deionized water, add trichloroacetic acid equivalent to 2.5% of the mass of the precipitate a, let it stand at 4°C for 120 minutes; centrifuge, take the supernatant filtrate and dialyze for 24 hours, change the dialysate (distilled water) ever...

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Abstract

The invention provides an application of water-soluble polysaccharide extracted from a rosaceae rubus plant, rubus suavissimus, in protection of liver and activation of acetaldehyde dehydrogenase.

Description

technical field [0001] The invention discloses a water-soluble polysaccharide extracted from Rubus sweet leaf of Rubus genus Rosaceae for protecting the liver and activating acetaldehyde dehydrogenase, which belongs to medical use. Background technique [0002] Acetaldehyde dehydrogenase (acetaldehyde dehydrogenase, ALDH) (EC1.2.1.10) (CAS [9028-91-5]), as a kind of aldehyde dehydrogenase, is responsible for catalyzing the oxidation of acetaldehyde to acetic acid. It plays a major role in alcohol metabolism and widely exists in various animals, plants and microorganisms. Mammalian acetaldehyde dehydrogenase can be divided into three categories according to its subcellular localization, structure and dynamic characteristics and the similarity of the original sequence: the first category exists in the cytoplasm (ALDH1), and the second category exists in the mitochondria (ALDH2 ), the third category is the inducible cytoplasmic aldehyde dehydrogenase and the inducible microsom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00C08B37/06C07H3/02C07H1/08A61P1/16A61P25/00A61P9/00A61P35/00
Inventor 邹晓青冯小婕彭圣明
Owner XIANGTAN UNIV
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