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PLANT EXTRACT COMPOSITION, and pharmaceutical COMPOSITION and APPLICATION THEREOF

A pharmaceutical composition and composition technology, which is applied in the field of plant extract composition, can solve the problem of no significant improvement in body weight or body fat, and achieve the goal of increasing the activity of carnitine acyltransferase-1, high safety, and inhibiting fat neogenesis Effect

Inactive Publication Date: 2015-11-11
CALIWAY BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In the past, although it has been documented that in adipocyte experiments, resveratrol can effectively inhibit fat accumulation in mature adipocytes or regulate the growth of precursor adipocytes, but at the same time, many documents have proved that in mouse experiments Inducing obesity in mice with a high-calorie diet and continuing to feed resveratrol during the process of inducing obesity with a high-calorie diet, the experimental results show that feeding resveratrol in animal experiments can reduce the body weight or body fat of mice (including visceral fat and subcutaneous fat) no significant improvement

Method used

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  • PLANT EXTRACT COMPOSITION, and pharmaceutical COMPOSITION and APPLICATION THEREOF
  • PLANT EXTRACT COMPOSITION, and pharmaceutical COMPOSITION and APPLICATION THEREOF
  • PLANT EXTRACT COMPOSITION, and pharmaceutical COMPOSITION and APPLICATION THEREOF

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0052] Preparation example 1. Formula combination of plant extract composition

[0053] The formula combination (wt%) of plant extract composition of table 1

[0054] Composition

Embodiment 1

[0055] Example 1. Preadipocyte inhibition experiment

[0056] In this example, preadipocyte 3T3-L1 (purchased from Taiwan Food Industry Research Institute, FIRDI) was mixed with 1×10 4 The cells / well were cultured in 96-well plates, and the control group (1% DMSO) and the test groups with a concentration of 50ppm were added to different wells, and the test groups were green tea extract, resveratrol, and green coffee beans. Extracts and compositions of the present invention LB001, LB004, LB005, LB006, LB007, LB008, LB008A, and each set of experiments were repeated three times. After 48 hours, the inhibitory effect of each test group on 3T3-L1 preadipocytes was analyzed by MTT cell survival test.

[0057] The result is as figure 1 As shown, the inhibitory effect of green tea extract or green coffee bean extract alone on preadipocytes is not good, and the effects of LB001, LB004, LB005, LB006, and LB007 in each composition are better in inhibiting the growth of preadipocytes ,...

Embodiment 2

[0058] Example 2 Adipocyte Inhibition Test During Differentiation

[0059] In this example, 3T3-L1 cells were treated with 3x10 4 The cells / well were cultured in 12-well plates, and on the fourth day, they were replaced with 3-isobutyl-1-methylxanthine containing 5 μg / ml insulin, 1 μM dexmethasone, and 0.5 mM. 1-methylxanthine) for differentiation, and at the same time add 50ppm test groups to each well, wherein the test groups are respectively green tea extract, resveratrol, green coffee bean extract and the composition of the present invention LB001, LB004 , LB005, LB006, LB007, LB008, LB008A. After 48 hours, the inhibitory effect of each test group on the differentiating 3T3-L1 adipocytes was analyzed by MTT cell survival test.

[0060] The result is as figure 2As shown, the inhibitory effect of applying green tea extract or green coffee bean extract alone on differentiating adipocytes is not good, and the effects of LB001, LB004, LB006, LB007 and LB008 on the growth of...

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Abstract

The present invention provides a plant extract composition for inhibiting adipocytes, reducing body fat, losing body weight or increasing lipid metabolism, wherein the composition comprises 1.5 wt % to 40 wt % of resveratrol and 10 wt % to 85 wt % green tea extract. The composition not only provides high safety, but also effectively suppresses preadipocytes, inhibits differentiating adipocytes, inhibits mature adipocytes, increases the activity of carnitine acyl transferase-1, decreases body fat and promotes weight loss, and regulates the expression of the leptin gene and resistin gene.

Description

technical field [0001] The present invention relates to a plant extract composition, especially a plant extract composition that can inhibit fat cells, reduce body fat, reduce body weight or promote fat metabolism; Application of adipocytes, reducing body fat, reducing body weight or promoting fat metabolism; the present invention also relates to a pharmaceutical composition, especially a pharmaceutical composition comprising the aforementioned plant extract composition. Background technique [0002] According to the World Health Organization (WHO), obesity is a global epidemic disease, in which more than 1.4 billion adults are overweight (BMI>25), and at least 500 million of these overweight people Clinically diagnosed as obese (BMI>30), and these obese people suffer from high blood pressure, dyslipidemia, diabetes, gout and other metabolic-related diseases, the probability of which is significantly higher than the average person. According to a 2007 report by the Jo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P3/04A61K31/05
CPCA61K36/82A61K31/05A61K36/42A61K36/605A61K36/74A61P3/04A61K2300/00
Inventor 凌玉芳
Owner CALIWAY BIOPHARM
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