Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparing method of radix scutellariae-gypsum oral preparation capable of relieving sore throat

A technology for oral preparations and extracts, which is applied in the field of preparation of traditional Chinese medicine compound preparations, can solve the problems of insufficient extraction of active ingredients, low transfer rate, low extraction efficiency of mineral medicinal gypsum, harmful co-solvent Tween-80, etc. Clinical application safety, avoiding application risks, and improving the uniformity of volatile oil content

Inactive Publication Date: 2015-11-04
TONGHUA GOLDEN-HORSE PHARM IND CO LTD
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are some unreasonable parts in the production process, such as insufficient extraction of active ingredients and low transfer rate, low extraction efficiency of animal medicine ox horn and mineral medicine gypsum in the prescription, volatile oil and instability, and harmful cosolvent Tween-80, etc. problems, to improve these problems to form a new process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation of Qinshi Liyan oral preparation, characterized in that the steps are as follows:

[0029] (1) Microwave extraction of volatile oil and active ingredients of gypsum: take gypsum, forsythia, mint, and perilla leaves and soak in water (1:50 ratio of material to liquid) for 1 hour, 300-600W microwave extraction of volatile oil for 60 minutes, collect volatile oil, and extract for later use.

[0030] (2) Hydroxypropyl-β-cyclodextrin inclusion volatile oil: Dissolve β-cyclodextrin in an appropriate amount of water, stir and heat to dissolve it completely, slowly drop the volatile oil dissolved in a small amount of absolute ethanol into the cooled β-cyclodextrin aqueous solution, at a temperature of 30 ℃ to 60 ℃, magnetically stirred at about 200 r / min for 3 to 5 hours, filtered under reduced pressure, washed with warm distilled water and absolute ethanol, and dried in vacuum to obtain solid clathrate things. The clathrate is ready for use.

[0031] (3) Extrac...

experiment example 1

[0041] Experimental example 1: Comparative study on the stability and uniformity of volatile oil before and after inclusion

[0042] Take the preparations prepared by the new process, and carry out volatility experiments for 3 months respectively (sampling at 20°C for 0 days, 1 month, 2 months, and 3 months, taking menthol in peppermint as an index component, and measuring the content by gas chromatography Determination); 10 samples produced at different time points of the same batch were taken respectively for homogeneity experiment, and menthol in peppermint was used as an index component, and gas chromatography was used to carry out, and the measurement results were as follows:

[0043] New technology (mg / 1000ml) Original process (mg / 1000ml) 0 day 1.71 0.89 January 1.68 0.75 February 1.67 0.62 March 1.59 0.45

[0044] New Technology original craft 1 1.71 0.89 2 1.70 0.87 3 1.75 0.69 4 1.75 ...

experiment example 2

[0046] Experimental Example 2: Comparative Study of Different Extraction Methods of Buffalo Horn

[0047] Brush the surface of the buffalo horn, plan it into thin slices, and grind it into fine powder. Use the following methods to extract and measure the total extract weight and amino acid (protein content).

[0048] 2.1 Alcohol extraction method: Weigh 50g of buffalo horn fine powder and put it in a 5000ml round bottom flask, prepare 50% ethanol, add 8 times the amount of 50% ethanol for the first time, that is, 400ml in the round bottom flask, connect the condensing reflux device, electric heating Heat the jacket to boiling, adjust the pressure to slightly boiling state, 1h. Filter, second (ditto) third (ditto).

[0049] The filtrate was recovered with a device for recovering ethanol under reduced pressure, and the ethanol was recovered. The remaining small amount of filtrate was placed in an evaporating dish that had been dried to constant weight, and evaporated to dryness...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of traditional Chinese medicine compound preparation and particularly relates to a preparing method of radix scutellariae-gypsum oral preparation capable of relieving sore throat. The method includes the steps of firstly, extracting volatile oil of gypsum, fructus forsythiae, mint and perilla leaf in a microwave manner; secondly, adding buffalo horn grinding fluid into artificial gastric juice extract and artificial intestinal juice extract; thirdly, jointly decocting fructus forsythiae, mint, perilla leaf and gypsum residues with radix scutellariae, rhizoma anemarrhenae, radix rehmanniae, red peony root, spina gleditsiae, dandelion and liquorice; fourthly, welling mixing the volatile oil clathrate compound and the extract obtained in the first step and the third step, adding the buffalo horn extract in the second step, adding 0.1% of agar and 0.2% of sorbic acid, well mixing, immediately filtering, cooling, adding the volatile oil clathrate compound obtained in the first step, 1% of apple essence and 1.5% of sodium cyclamate, adding distilled water to reach 1000ml, split charging into glass ampoules of 10ml, and sterilizing. The method is simple and easy to operate and stable in experiment results.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of traditional Chinese medicine compound preparations, that is, a preparation method of Qinshi Liyan oral preparations. Specifically design an advanced preparation method of Qinshi Liyan oral preparation with the effect of clearing throat and throat, optimize the extraction method of traditional Chinese medicine in the prescription, especially improve the extraction method of animal horn medicine in the prescription, and improve the extraction effect , increase the extraction yield, make full use of medicinal material resources, and at the same time, through animal experiments, it has been fully confirmed that the effect of clearing the throat and sharpening the throat has been increased. Background technique [0002] Qinshi Liyan Oral Liquid is a compound oral liquid composed of Scutellaria baicalensis, raw gypsum, buffalo horn, forsythia, dandelion, Anemarrhena, rehmannia glutinosa, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/48A61K9/08A61K36/8964A61P11/04A61K35/32A61K33/06A61K47/69
Inventor 朱志杰刘永刚邢春娇杨俊高雪梅于霞宗
Owner TONGHUA GOLDEN-HORSE PHARM IND CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com