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New application of teprenone

A technology of teprenone and opioids, applied in the field of medicine, can solve problems such as weight loss

Inactive Publication Date: 2015-10-07
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether teprenone can be used to prevent or treat opioid addiction and weight loss due to withdrawal has not been reported

Method used

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  • New application of teprenone
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Teprenone inhibits weight loss in mice caused by morphine addiction and withdrawal

[0017] The mice were divided into 4 groups, 10 mice in each group, and the initial body weight of the mice in each group was weighed and recorded in advance. Both the control group (C) and the morphine group (Mor) were given normal saline by intragastric administration for 16 consecutive days in advance; the GGA and morphine GGA group (GGA+Mor) were given GGA (800 mg / kg) by intragastric administration for 16 consecutive days in advance. On the eighth day, the initial time of the conditioned place preference experiment was measured for 15 minutes and the body weight of the mice was measured. After that, on the 9th, 11th, 13th, and 15th day respectively, group C and GGA were intraperitoneally injected with normal saline 2 hours after gavage. Mor group and GGA+Mor group received intraperitoneal injection of 20 mg / kg of morphine 2 hours after intragastric administration, and int...

Embodiment 2

[0018] Example 2: Teprenone inhibits the increased expression of NR2B in the NAc region induced by morphine relapse

[0019] Tissue collection and storage: After the mice were killed by cervical dislocation, the chest was opened, the venous end of the right atrium was cut open, and the left ventricle was perfused with 1×PBS buffer solution at a flow rate of 20 rpm. Bai Hou stopped. Then the tissues in the NAc area were taken, divided into liquid nitrogen, quick-frozen, marked, and stored in a -80°C refrigerator.

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Abstract

The invention discloses new application of teprenone, namely application to preparing a medicine for preventing and / or treating weight reduction caused by opioid drug habituation and abstinence relapsing, and relates to the technical field of medicines. The teprenone can resist mice weight reduction caused by morphine habituation and abstinence; in addition, in terms of the molecular level, GGA obviously restrains NAc area NR2B expression rise induced by morphine relapsing lighting; and the teprenone can be used for preventing and treating weight reduction caused by opioid drug habituation and abstinence relapsing.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new medical application of teprenone, specifically the application of teprenone in the preparation of drugs for preventing and / or treating opioid drug addiction and weight loss caused by withdrawal and relapse . Background technique [0002] Opioid drug addiction refers to a chronic recurrent encephalopathy caused by long-term heavy use of opioid drugs. Severe withdrawal symptoms may follow. Once a drug abuser becomes addicted, it is very difficult to get rid of drugs, and the relapse rate after drug withdrawal is still as high as 95%. Drug addiction and relapse have become one of the social hazards. Opioid abusers experience euphoria, insomnia, tremors, vomiting, diarrhea, and weight loss, among other symptoms. Common opioids include morphine, heroin, and opium. The current treatment methods for opioid addiction include natural withdrawal, drug withdrawal and non-drug with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/121A61P25/36
Inventor 白洁朱光洁周小爽曾宪思
Owner KUNMING UNIV OF SCI & TECH
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