Preparation composition containing broccoli extract with effects of improving immunity and suppressing tumors and preparation method of preparation composition
A composition and anti-tumor technology, applied in the directions of anti-tumor drugs, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as the preparation process of granules, tablets, and capsules, and reports on related patents that have not been seen.
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Embodiment 1
[0013] Embodiment 1: the preparation of broccoli extract
[0014] Get 3kg broccoli seeds and pulverize through pulverizer, carry out mixed degreasing with 3kg sherwood oil, then isolate sherwood oil, add 15kg water and mix homogeneously, add acetic acid in the mixing solution, pH is adjusted to 6, add 300 gram mixed enzymes (papain : cellulase=1: 1), add deionized water 10kg, add appropriate amount of vitamin C, keep pH to be 6, stir at room temperature (25 ℃) and carry out hydrolysis reaction, make the glucosinolate in broccoli seed convert into radish Sulfur, hydrolysis reaction 8h. The solid part was separated by centrifugation, and the hydrolyzate was added to a vacuum concentration tank, and the extract was concentrated to half of the original volume at a vacuum degree of 0.06Mpa and 30°C. The concentrated solution was added to a chromatographic column with a column volume of 2 L of Hp850 resin, and the flow rate of the sample was 20 ml / min. After the resin was adsorbed,...
Embodiment 2
[0015] Embodiment 2: the preparation of composition particle
[0016] Take 1L of broccoli extract in Example 1, mix with 0.5kg chitosan oligosaccharide, 1kg ganoderma lucidum polysaccharide, 1kg cordyceps polysaccharide and 1kg dextrin, add deionized water, adjust to a slurry with a solid content of 10%, and spray dry Make powder, the air inlet temperature is 180°C, and the air outlet temperature is 80°C to obtain the composition powder. Add 20% starch to the powder of the composition, adopt fluidized bed granulation method to make granules, and dry to obtain granules.
Embodiment 3
[0017] Embodiment 3: the immune function test of composition
[0018] Experimental method: the experimental animals are selected clean grade female mice (body weight 20g ± 2g), divided into four groups, i.e. blank control group, low dose group, middle dose group and high dose group, the broccoli composition fed to the mice is The prepared composition granule of embodiment 2 is dissolved in the solution that distilled water gains, low, medium, high dose group is calculated by 5 times, 10 times, 30 times of people's recommended dose (people's recommended dose is 2-4g / d), respectively 300mg / kg for the low dose group, 600mg / kg for the middle dose group, and 1800mg / kg for the high dose group. The control group was given the same amount of distilled water. With reference to the methods in the "Technical Specifications for Health Food Inspection and Evaluation" issued by the Ministry of Health and Xue Bin's "Immunotoxicology Experimental Technology" (Beijing Medical University, Chin...
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