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Preparation method for preparing hydrophilic quantum dots based on novel amphiphilic polymer ultrasonic emulsion process

An amphiphilic and polymer technology is applied in the field of preparation of new amphiphilic polymer ultrasonic emulsion method to prepare hydrophilic quantum dots. low cost effect

Inactive Publication Date: 2015-09-16
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Generally speaking, the method of hydrophilic modification needs to meet many conditions at the same time. For example, the modified quantum dots should maintain a small particle size, have good biocompatibility, and have functional groups on the surface that can couple biomolecules and Targeting molecules without non-specific reactions in the biological environment, currently there is no modification method that can meet all the above requirements at the same time

Method used

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  • Preparation method for preparing hydrophilic quantum dots based on novel amphiphilic polymer ultrasonic emulsion process
  • Preparation method for preparing hydrophilic quantum dots based on novel amphiphilic polymer ultrasonic emulsion process
  • Preparation method for preparing hydrophilic quantum dots based on novel amphiphilic polymer ultrasonic emulsion process

Examples

Experimental program
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Effect test

Embodiment example 1

[0030] Implementation Case 1: Based on the novel polymaleic anhydride-alt-1-octadecene phacoemulsification modified quantum dots.

[0031] 1) 0.4mg polymaleic anhydride-alt-1-octadecene (Poly(maleic anhydride-alt-1-octadecene), PMAO) and 100uL quantum dot QDs are added to the reactor (mass fraction ratio is 50: 1), then add 200uL methylene chloride to the reactor to form an oil phase whose polymaleic anhydride-alt-1-octadecene concentration is 2mg / mL;

[0032] 2) Add 40uL ring-opener 2,2′-(ethylenedioxy)bis(ethylamine) to the reactor, and then add 4mL deionized water to the reactor to form 2,2′-(ethylenedioxy)bis (Ethylamine) concentration is the aqueous phase of 10uL / mL;

[0033] 3) Evenly drop the above-mentioned oil phase into the above-mentioned water phase to form a water-oil uniform emulsion dispersion system, wherein the volume ratio of the oil phase and the water phase is adjusted to 1:20, and ultrasonic dispersion is performed with an ultrasonic disperser, and the ul...

Embodiment example 2

[0036] Implementation Case 2: Based on the novel polymaleic anhydride-alt-1-octadecene ultrasonic emulsification modified quantum dots.

[0037]1) Add 0.8mg polymaleic anhydride-alt-1-octadecene (Poly(maleic anhydride-alt-1-octadecene), PMAO) and 100uL quantum dots to the reactor (the mass fraction ratio is 100:1 ), then in the reactor, add 400uL methylene chloride to form the oil phase that polymaleic anhydride-alt-1-octadecene concentration is 2mg / mL;

[0038] 2) Add 80uL ring-opener 2,2′-(ethylenedioxy)bis(ethylamine) to the reactor, and then add 8mL deionized water to the reactor to form 2,2′-(ethylenedioxy)bis (Ethylamine) concentration is the aqueous phase of 10uL / mL;

[0039] 3) Evenly drop the above-mentioned oil phase into the above-mentioned water phase to form a water-oil uniform emulsion dispersion system, wherein the volume ratio of the oil phase and the water phase is adjusted to 1:20, and ultrasonic dispersion is performed with an ultrasonic disperser, and the ...

Embodiment example 3

[0042] Implementation Case 3: Based on the novel polymaleic anhydride-alt-1-octadecene phacoemulsification modified quantum dots.

[0043] 1) Add 1.6mg of polymaleic anhydride-alt-1-octadecene (Poly(maleic anhydride-alt-1-octadecene), PMAO) and 100uL quantum dots to the reactor (the mass fraction ratio is 200:1 ), then add 800uL methylene chloride to the reactor to form the oil phase that polymaleic anhydride-alt-1-octadecene concentration is 2mg / mL;

[0044] 2) Add 160uL ring-opener 2,2′-(ethylenedioxy)bis(ethylamine) to the reactor, and then add 16mL deionized water to the reactor to form 2,2′-(ethylenedioxy)bis (Ethylamine) concentration is the aqueous phase of 10uL / mL;

[0045] 3) Evenly drop the above-mentioned oil phase into the above-mentioned water phase to form a water-oil uniform emulsion dispersion system, wherein the volume ratio of the oil phase and the water phase is adjusted to 1:20, and ultrasonic dispersion is performed with an ultrasonic disperser, and the u...

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Abstract

The invention relates to a preparation method for preparing hydrophilic quantum dots based on a novel amphiphilic polymer ultrasonic emulsion process. The preparation method comprises the following steps: adding polymaleic anhydride-alt-1-octadecene and quantum dots into a reactor, and then adding dichloromethane into the reactor to form an oil phase of the polymaleic anhydride-alt-1-octadecene; adding a ring opening agent 2,2'-(ethylene dioxy)bis(ethylamine) into the reactor, and then adding deionized water into the reactor to form an aqueous phase of the 2,2'-(ethylene dioxy)bis(ethylamine); dropwise adding the oil phase into the aqueous phase to form an emulsion disperse system with uniform oil and water, and performing ultrasonic dispersion on the obtained emulsion disperse system with an ultrasonic disperser; performing rotary evaporation on the emulsion on a rotary evaporator at room temperature; after an organic solvent volatilizes, performing further rotary evaporation until the solution is clear before stopping the rotary evaporation; and centrifuging to obtain hydrophilic quantum dots, wherein the effective particle size is 40-140nm. The preparation method has the advantages of simple preparation process, short cycle and high yield and is suitable for mass production.

Description

technical field [0001] The invention relates to a method for preparing hydrophilic quantum dots by a novel amphiphilic polymer ultrasonic emulsion method, and belongs to the technical field of nanomaterial preparation. Background technique [0002] In recent years, quantum dots have been widely used in biomedical detection due to their unique optical properties. High-quality quantum dots usually have a core-shell structure, such as CdSe / ZnS. The existence of the shell layer can ensure the stability of the fluorescence properties of quantum dots. . However, the process of synthesizing quantum dots is mostly completed in the organic phase under high temperature conditions. Although the obtained quantum dots have good optical properties, the surface of the quantum dots is covered with a large number of ligand molecules and presents hydrophobicity. , can only be dissolved in organic solvents, such as cyclohexane, chloroform, etc., and cannot be directly applied to biological sy...

Claims

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Application Information

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IPC IPC(8): C09K11/02
Inventor 常津武玉东宫晓群李雪
Owner TIANJIN UNIV
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