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A kind of aqueous phase preparation method of bismuth sulfide/protein composite nanosphere

A technology of protein compounding and nanospheres, which is applied to animal/human proteins, chemical instruments and methods, albumin peptides, etc., can solve the problems of unfavorable later application, unstable product shape, easy agglomeration into large pieces, etc., and achieve the goal of preparation The effect of short cycle, controllable particle size and simple experimental equipment

Inactive Publication Date: 2016-08-24
NANJING UNIV OF POSTS & TELECOMM
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Problems solved by technology

[0006] The present invention mainly proposes a water-phase preparation method of bismuth sulfide / protein composite nanospheres, which solves the need for high-temperature heating in the prior art, and the shape of the obtained product is not fixed, and it is easy to agglomerate into large pieces, which is not conducive to later application and other technical issues

Method used

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  • A kind of aqueous phase preparation method of bismuth sulfide/protein composite nanosphere
  • A kind of aqueous phase preparation method of bismuth sulfide/protein composite nanosphere
  • A kind of aqueous phase preparation method of bismuth sulfide/protein composite nanosphere

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Embodiment 1

[0027] The first step: add 2.5 mmol of mannitol to 25 mL (10 mg / mL) bovine serum albumin aqueous solution, the purity of the bovine serum albumin is >98%, the molecular weight is 68000, after stirring and dissolving at room temperature, add 1 One mmol of bismuth nitrate pentahydrate particles was stirred and dissolved at room temperature for 10 min to form a mixed solution containing bismuth ions and protein;

[0028] Step 2: Slowly add 5 mL (300 mmol / L) thioacetamide solution dropwise into the bismuth ion-protein mixture, and stir at room temperature for 5 min to form a bismuth-sulfur bovine serum albumin mixture;

[0029] Step 3: Heat the bismuth-sulfur bovine serum albumin mixture in a 35°C water bath for 2 h, then perform centrifugation, and wash the black solid obtained by centrifugation with deionized water and ethanol three times in sequence, and wash at 30°C After vacuum drying for 12 h, bismuth sulfide / protein composite nanospheres were prepared.

[0030] The experim...

Embodiment 2

[0032] Step 1: Add 1 mmol of bismuth nitrate pentahydrate particles to 25 mL (10 mg / mL) bovine serum albumin aqueous solution, stir and dissolve at room temperature for 10 min;

[0033] Step 2: Slowly add 5 mL (300 mmol / L) thioacetamide solution dropwise to the above mixture, and stir at room temperature for 5 minutes to form a bismuth-sulfur bovine serum albumin mixture.

[0034] The experimental results show that in the absence of mannitol, bismuth ions are easily hydrolyzed into white solid insoluble matter, which makes the reaction unable to continue normally.

Embodiment 3

[0036] Step 1: Add 2.5 mmol of mannitol to 25 mL of deionized water, stir and dissolve at room temperature, then add 1 mmol of bismuth nitrate pentahydrate particles, stir and dissolve at room temperature for 10 min to form a solution containing bismuth ions;

[0037] Step 2: Slowly add 5 mL (300 mmol / L) of thioacetamide solution dropwise into the solution containing bismuth ions, and stir for 5 min at room temperature to form a bismuth-sulfur mixture;

[0038] Step 3: Heat the bismuth-sulfur mixture in a 35°C water bath for 2 h, then perform centrifugation, wash the black solid produced by centrifugation with deionized water and ethanol three times in sequence, and dry it in vacuum at 30°C After 12 h, bismuth sulfide nanomaterials were prepared.

[0039] The experimental results show that in the absence of bovine serum albumin, bismuth sulfide nanomaterials can still be synthesized, but the obtained products have different sizes, large particle diameters, poor dispersion, and...

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Abstract

The invention discloses a water-phase preparation method of bismuth sulfide / protein composite nanospheres. Mannitol is added as a ligand, and bismuth sulfide / protein composite nanospheres are prepared for the first time in the water phase at room temperature. The bismuth sulfide prepared by the invention / Protein composite nanospheres have the characteristics of porous structure, large specific surface area, uniform shape, controllable size, and low biological toxicity. They can be used as biomedical probes and have potential application prospects in medical imaging such as CT. The invention states The method has the advantages of simple equipment, mild conditions, low energy consumption, short preparation cycle and easy realization, and is an ideal method for preparing bismuth sulfide / protein composite nanomaterials.

Description

technical field [0001] The invention relates to a water-phase preparation method of nanocomposite materials, in particular to a water-phase preparation method of bismuth sulfide / protein composite nanospheres. Background technique [0002] With its high surface activity, unique optical, electrical, magnetic properties, and extremely small three-dimensional structure, nanomaterials adapt to the current development trends of ultra-micronization, high-density integration, and low energy consumption of components, while metal oxide semiconductor nanomaterials Materials are an important part of nanomaterials. Scientists have studied various methods to synthesize metal oxide semiconductor nanomaterials with various shapes. [0003] Bismuth sulfide is an important semiconductor material with potential applications in thermoelectric, electronic and optoelectronic devices and infrared spectroscopy. Its forbidden band width is 1.2~1.7eV, which can be used to make photoelectric convers...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G29/00C07K14/765C07K14/805
Inventor 沈清明樊晓慧范曲立黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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