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Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation

A pharmaceutical preparation and hypoglycemic technology, applied in the field of pharmaceutical preparations, can solve the problems of gastrointestinal irritation, blood phase liver function, renal function damage, hypoglycemia reaction, etc.

Inactive Publication Date: 2015-08-26
陈爱华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects of these oral chemicals are mainly manifested in the damage to the blood phase, liver function, and kidney function, which will cause diabetic cardiovascular and cerebrovascular complications, prone to hypoglycemia, irritating the gastrointestinal tract, and producing anorexia , nausea, vomiting, and even diarrhea
Therefore, it is urgent to choose high-efficiency and long-term use without any toxic and side effects, reliable curative effect, and convenient hypoglycemic drugs to take. Drugs have certain curative effects for the treatment of diabetes. The efficacy of pharmaceutical preparations in treating diabetes is not significant, and the advantages of traditional Chinese medicine in treating diabetes cannot be brought into play

Method used

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  • Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation
  • Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation
  • Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Take 20g of lotus root, 18g of lacquer tree heart, 20g of spoon leaf Kalanchoe, 15g of old snake head, 20g of Yiwei medicinal root, 18g of ground peanut, 16g of black terminalia, 14g of apocynum, 18g of water flow bean, 20g of Chinese bean root , mix, add water to decoct twice, add water for the first time to 8 times the weight of the medicinal material, decoct for 1.5h, add water for the second time to 6 times the weight of the medicinal material, decoct for 1h, combine the decoction, filter, and filtrate Concentrate to a relative density of 1.10 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 65%, stir, let stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.20 (65°C) liquid, spray-dried (conditions are that the air inlet temperature is 100°C, the air outlet temperature is 80°C, the material temperature is 80°C, the atomization pressure is 0.2 MPa, and the s...

Embodiment 2

[0014] Example 2: Take 20g of the root of the lotus root, 18g of the heart of the sumac tree, 20g of the spoon leaf Kalanchoe, 15g of the old snake head, 20g of the root of the medicine, 18g of the ground peanut, 16g of the black terminal seed, 14g of the apocynum, 18g of the water flow bean, and 20g of the medicinal material of the carob. , mix, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal material, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal material, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate to The relative density is 1.15 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 75%, stir, let it stand for 24 hours, filter, recover the ethanol from the filtrate and concentrate it to a concentrated solution with a relative density of 1.25 (65°C), After spray drying (the conditions are that the air inlet te...

Embodiment 3

[0015] Example 3: Take 20g of lotus root, 18g of lacquer tree heart, 20g of spoon leaf Kalanchoe, 15g of old snake head, 20g of Yiwei medicinal root, 18g of ground peanut, 16g of black terminal seed, 14g of apocynum, 18g of water flow bean, and 20g of medicinal materials , mix, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, add water for the second time to 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoction, filter, Concentrate the filtrate to a relative density of 1.15 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 75%, stir, let stand for 24 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density of 1.25 (65°C) The extract is spray-dried (the conditions are that the inlet air temperature is 120°C, the outlet air temperature is 90°C, the material temperature is 90°C, the ato...

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Abstract

The invention belongs to the field of drugs, and discloses a pharmaceutic preparation with a blood glucose reducing effect. The pharmaceutic preparation comprises 20 parts of beet root, 18 parts of varnish tree wood, 20 parts of kalanchoe spathulata, 15 parts of warty thladiantha, 20 parts of false indigo root, 18 parts of polygala crotalarioides Buch.-Ham, 16 parts of black Chinese olive kernel, 14 parts of apocynum venetum, 18 parts of pongamia pinnata pierre ex merr, and 20 parts of root of delavay clovershrub. The dosage form can be granule, tablet and capsule. The invention further discloses a preparation method which comprises the following steps: adding water for decoction, concentrating, performing alcohol precipitation, carrying out spray drying, grinding obtained particles into dry extract powder, and adding auxiliary materials to prepare the needed preparation. The invention further discloses application of the pharmaceutic preparation in preparation of a drug for reducing blood glucose.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a pharmaceutical preparation with hypoglycemic effect and its preparation method and application. Background technique [0002] In addition to insulin, the current clinical treatment of type 2 drugs is mainly oral hypoglycemic drugs, which are roughly divided into sulfonylureas, biguanides, pharmaceutical preparations, other hypoglycemic drugs and auxiliary drugs. However, the side effects of these oral chemicals are mainly manifested in the damage to the blood phase, liver function, and kidney function, which will cause diabetic cardiovascular and cerebrovascular complications, prone to hypoglycemia, irritating to the gastrointestinal tract, and producing anorexia , nausea, vomiting and even diarrhea. Therefore, it is urgent to choose high-efficiency and long-term use without any toxic and side effects, reliable curative effect, and convenient hypoglycemic drugs to take. Drugs ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61P3/10
Inventor 陈爱华
Owner 陈爱华
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