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Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS-PDMAEMA

A hybrid material and sensitive technology, applied in the fields of chemical industry and new materials, can solve the problems of poor product dispersibility, complicated preparation process, low monomer selectivity, etc., and achieve high preparation yield, no environmental pollution, and stereoselectivity. strong effect

Inactive Publication Date: 2015-08-12
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And these preparation methods all have certain deficiencies, such as less monomer selectivity, slow polymerization rate, poor product dispersibility, complicated preparation process, low yield and high cost.

Method used

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  • Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS-PDMAEMA
  • Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS-PDMAEMA
  • Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS-PDMAEMA

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1: Take 5.56 g of dimethylaminoethyl methacrylate monomer in a 25 mL single-necked round bottom flask. Take 100 mg of 4-cyano-4-(thiobenzoyl)valeric acid and 20.42 mg of azobisisobutyronitrile powder in a 50 mL beaker, add 10 mL of dioxane to dissolve. Then the two were mixed, and the one-necked flask was evacuated at 0°C through the "T-shaped" tee, and nitrogen gas was introduced. Under the protection of nitrogen, it was placed in a 90°C oil bath with magnetic stirring for 12 h. After the reaction was completed, the flask was cooled to room temperature and ventilated to the atmosphere, and the cooled solution was rotated at 45° C. to remove the solvent to obtain a sample. Dissolve the sample in 10 mL of dichloromethane, add it dropwise to 300 mL of ice petroleum ether, let it stand for 4 h, remove the upper liquid, and obtain a viscous sample at the bottom. The above steps were repeated twice, and finally the samples were vacuum-dried at 45 °C for 24 h. An o...

Embodiment 2

[0031] Same as Example 1, but the amount of dimethylaminoethyl methacrylate in the first step of synthesis is changed from 5.56 g to 19.46 g, monomer (dimethylaminoethyl methacrylate) and chain transfer agent (4 -cyano-4-(thiobenzoyl)valeric acid) and initiator (azobisisobutyronitrile) molar ratio was changed to 350:1:0.3.

Embodiment 3

[0033] Same as Example 1, but the amount of dimethylaminoethyl methacrylate in the first step of synthesis is changed from 5.56 g to 11.12 g, monomer (dimethylaminoethyl methacrylate) and chain transfer agent (4 The molar ratio of -cyano-4-(thiobenzoyl)valeric acid) to the initiator (azobisisobutyronitrile) is 200:1:0.3.

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Abstract

The invention belongs to the technical filed chemical engineering and new materials, and concretely relates to a preparation method of a temperature and pH sensitive organic / inorganic hybrid material POSS-PDMAEMA. The method comprises the following steps: synthesizing polydimethylaminoethyl methacrylate through adopting a reversible addition-fragmentation chain transfer polymerization technology, and reacting polydimethylaminoethyl methacrylate with octavinyl POSS through a thiol-ene click chemical reaction to generate the organic / inorganic hybrid material POSS-PDMAEMA. In an aqueous solution, the POSS-PDMAEMA self-assembles with the change of the temperature and the pH value and forms micelle. The method has the characteristics of simplicity, convenience, high preparation yield and no pollution to environment, and the prepared organic / inorganic hybrid material POSS-PDMAEMA has temperature and pH sensitivity, is a new-generation high-performance intelligent material product, and can be applied to medicinal fields of organic dye adsorption, heavy metal adsorption and in vivo delivery of insoluble anticancer medicines.

Description

technical field [0001] The invention belongs to the technical field of chemical engineering and new materials, and in particular relates to a preparation method of an organic / inorganic hybrid material POSS-PDMAEMA with temperature and pH sensitivity. Background technique [0002] Environmentally responsive materials can respond to external stimuli in a timely manner, and are a class of smart materials that have attracted much attention. Environmentally responsive amphiphilic polymer materials can self-assemble into aggregates of various shapes such as micelles and vesicles in selective solvents. These aggregates can not only respond to external temperature, pH, salt and other stimuli In response to the source, organic dyes and drugs that are poorly soluble in water can also be loaded into the hydrophobic segment, so it has application value in the fields of environment and biomedicine. Compared with pure polymer environmental responsive materials, environmentally responsive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/34C08F8/42C08J3/07
Inventor 杨正龙刘芯岩
Owner TONGJI UNIV
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