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Medicinal composition for resisting helicobacter pylori and preparation method as well as application thereof

A technology of Helicobacter pylori and composition, applied in the field of antimicrobial drugs, to achieve the effect of simple preparation method, less adverse reactions and enhanced effect

Active Publication Date: 2015-08-05
山东豪瑞恩制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in recent years, with the increase of H.pylori's resistance to antibiotics, the eradication rate of traditional standard triple therapy has dropped to less than 70%, and there are more cases of patients with adverse reactions such as nausea, discomfort, and skin itching

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A pharmaceutical composition of anti-gastric Helicobacter pylori in tablet form, which is made of the following components in parts by weight: 10 parts of vonoprazan, 50 parts of amoxicillin, 100 parts of levofloxacin, microcrystalline cellulose 65 parts, 350 parts of lactose monohydrate, 30 parts of povidone, 20 parts of low-substituted hydroxypropyl cellulose and 5 parts of magnesium stearate. The preparation method comprises the following steps: weighing each component according to the formula quantity, mixing uniformly, then adopting wet granulation, drying, and tableting to obtain the product.

Embodiment 2

[0026] An anti-gastric Helicobacter pylori pharmaceutical composition in the form of an injection, which is made of the following components in parts by weight: 50 parts of vonoprazan, 500 parts of amoxicillin, 100 parts of moxifloxacin, and 450 parts of NaCl and water for injection, the mass volume concentration of amoxicillin in the pharmaceutical composition in the form of injection is 1 g / L. The preparation method comprises the following steps: weighing each component according to the formula amount, dissolving NaCl in water for injection, then adding vonorazan, amoxicillin and moxifloxacin and stirring until completely dissolved, then filtering until clarity, Potting, sterilization, that is.

Embodiment 3

[0028] An anti-gastric Helicobacter pylori pharmaceutical composition in the form of sustained-release pellets, which is made of the following components in parts by weight:

[0029] Ball core prescription: 20 parts of Wonorazan, 50 parts of amoxicillin, 150 parts of levofloxacin, 15 parts of microcrystalline cellulose, 5 parts of hydroxypropyl methylcellulose, 250 parts of water;

[0030] Coating prescription: 185 parts of 25% ethylcellulose aqueous dispersion, 122 parts of water.

[0031] The preparation method is as follows: respectively crush microcrystalline cellulose, vonorazan, amoxicillin, and levofloxacin through a 100-mesh sieve, weigh them according to the pill core prescription, mix them evenly, and use hydroxypropyl methylcellulose aqueous solution as a binder , make pellets, dry them at 50-60°C, select pellets of 20-30 meshes, and set aside;

[0032]Put the prepared and selected pellets in a fluidized bed, adopt the bottom spray method, and suspend and fluidize ...

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PUM

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Abstract

The invention relates to a medicinal composition for resisting helicobacter pylori. The medicinal composition comprises the following components in parts by weight: 50-500 parts of component A, 100-500 parts of component B and 5-50 parts of component C, wherein the component A is amoxicillin; the component B is selected from levofloxacin and pharmaceutically acceptable salts thereof, moxifloxacin and pharmaceutically acceptable salts thereof; the component C is selected from Vonoprazan and pharmaceutically acceptable salts thereof. The invention also provides a preparation method and application of the medicinal composition. The medicinal composition for resisting the helicobacter pylori has a strong effect of resisting the helicobacter pylori and has less adverse reaction and wide application, and the preparation method is simple and is easy to operate.

Description

technical field [0001] The invention relates to the field of antimicrobial drugs, in particular to a pharmaceutical composition for resisting gastric Helicobacter pylori, a preparation method and an application thereof. Background technique [0002] Gastric Helicobacter pylori, also known as Helicobacter pylori (H. pylori), is a Gram-negative, S-shaped or curved obligate microaerophilic bacteria. H. pylori is the pathogen with the highest infection rate in the world. H. pylori infection is globally distributed. About half of the world's population is infected with this bacteria. The H. pylori infection rate in my country is relatively high, ranging from 42% to 90%, with an average of 59%. H.pylori is an important pathogen of upper gastrointestinal diseases. Chronic gastritis, peptic ulcer, postoperative early gastric cancer, gastric mucosa-associated lymphoid tissue lymphoma and other digestive system diseases should be eradicated for treatment. Unexplained iron deficiency ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5383A61K31/4709A61P31/04A61P1/04A61P35/00A61K31/43A61K31/4439
Inventor 陈亮冯文周
Owner 山东豪瑞恩制药有限公司
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