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Novel preparation method of nano selenium-catathelasma ventricosum polysaccharide complex

A technology of pine mushroom and nano selenium, applied in the field of biomedicine, can solve the problems of instability of nano selenium, loss of biological activity and availability, etc., and achieves low cost, good bioavailability, stability, and reaction. mild effects

Active Publication Date: 2015-07-29
成都雅乐鲜生物科技有限公司
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Problems solved by technology

[0006] Studies have found that red nano-selenium is very unstable if there is no dispersant or stabilizer in the liquid phase, and it is very easy to aggregate to form large particles (it is generally believed that the particle size of nano-selenium is negatively correlated with activity), while Loss of biological activity and availability

Method used

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Embodiment Construction

[0036] The present invention will be further described below in conjunction with experiments.

[0037] 1. Experimental scheme and results

[0038] 1.1 Sample

[0039] Fresh spinach mushroom bought in local market

[0040] 1.2 Sample pretreatment

[0041] 1.2.1 Cleaning: Use a special plastic scraper to remove the mud stains on the surface of an appropriate amount of fresh pine mushrooms (if washed with water, the surface polysaccharides will be lost).

[0042]1.2.2 Cut into pieces: Cut the cleaned fresh pine mushrooms into pieces, and divide each piece of pine mushroom into four pieces.

[0043] 1.2.3 Freeze-drying: put the chunks of P. punctatus pine stem into a freeze-dryer to obtain a sample with a moisture content of less than 5%.

[0044] 1.3 Preparation of Alcoholic Extract of Pinus chinensis Mushroom

[0045] 1.3.1 Pulverization: crush the pretreated pine mushroom, and pass through a 40-mesh sieve to obtain the powder of pine mushroom.

[0046] 1.3.2 Washing with ...

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Abstract

The invention provides a novel preparation method of a nano selenium-catathelasma ventricosum polysaccharide complex. Catathelasma ventricosum polysaccharides are taken as a dispersing agent, waste (an ethanol scrubbing solution) in the catathelasma ventricosum polysaccharide extraction process is taken as a reaction reducing agent, the waste is reused, compared with traditional reducing agents such as vitamin C and the like, the novel reducing agent has the better reducing property (the particle size of nano selenium is decreased by 23.8%); (2) in the whole preparation process, reaction conditions are mild, the cost is low, operation is simple, industrial popularization is easy, the particle size of the obtained nano selenium-catathelasma ventricosum polysaccharide complex is only 32.7 nm and can still be kept to be 62.7 nm after stored for 60 days, and the complex has very good bioavailability and stability; (3) the catathelasma ventricosum polysaccharides and the nano selenium in the nano selenium-catathelasma ventricosum polysaccharide complex can have a synergistic effect to promote the antioxidant activity of the complex.

Description

technical field [0001] The invention relates to a preparation method of a polysaccharide complex effective for treating diabetes, in particular to a novel preparation method of a nano-selenium-spindle pine mushroom polysaccharide complex, which belongs to the technical field of biomedicine. Background technique [0002] Diabetes mellitus is a comprehensive metabolic disorder characterized by hyperglycemia. According to data released by the World Health Organization in 2014, the number of people with diabetes worldwide has reached 347 million. [0003] Because the level of oxidative stress in diabetic patients is significantly higher than that of normal people, tissues such as kidneys, eyes, heart, blood vessels and nerves are extremely vulnerable to oxidative damage, which induces various diabetic complications. Diabetic complications are also considered to be the main hazards of diabetes on the body. Recent studies have found that the intake of antioxidants can significan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61P3/10C08B37/00A61K31/715
Inventor 刘韫滔陈荻刘爱平韩国全张清刘书亮李诚周康胡欣洁吴贺君
Owner 成都雅乐鲜生物科技有限公司
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