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Preparation and detection methods for chemically modified electrode for selectively measuring dopamine

A chemical modification and dopamine technology, applied in the field of electrochemistry, can solve problems such as system pollution, achieve the effects of improving reversibility, accelerating electron transfer rate, and enhancing electrocatalytic oxidation

Inactive Publication Date: 2015-07-15
SHENYANG NORMAL UNIV
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Problems solved by technology

[0004] The technical problem to be solved in the present invention is to provide a preparation and detection method of a chemically modified electrode for selective determination of dopamine, to solve the problem that DA, AA and UA have similar oxidation potentials on conventional electrodes and the oxidation products of dopamine will bring pressure to the system. to the problem of pollution effects

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  • Preparation and detection methods for chemically modified electrode for selectively measuring dopamine
  • Preparation and detection methods for chemically modified electrode for selectively measuring dopamine
  • Preparation and detection methods for chemically modified electrode for selectively measuring dopamine

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Embodiment Construction

[0025] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0026] The invention provides a chemically modified electrode for selective determination of dopamine. The pretreatment process of the glassy carbon electrode used is: after polishing the surface of the glassy carbon electrode with metallographic sandpaper, α-alumina and α-alumina of 1.0 μm and 0.3 μm are respectively used 0.05μm γ-alumina powder is polished until the surface of the glassy carbon electrode is as smooth as a mirror, and then the alumina powder remaining on the electrode surface is ultrasonically rinsed with twice distilled water, and then placed in 0.5mol / L sulfuric acid at - Scan the cyclic voltammetry curv...

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Abstract

The invention belongs to the electrochemical field, and particularly relates to preparation and detection methods for a chemically modified electrode for selectively measuring dopamine. The preparation comprises the following steps: preparing a multi-walled carbon nano-tube suspension, pre-treating a glassy carbon electrode, dripping and coating the prepared multi-walled carbon nano-tube suspension on the electrode, and drying for later use, soaking the electrode in 4-(2-pyridyl-azo) resorcinol solution, taking phosphate buffer as base solution, and carrying out cyclic scanning in a potential range from minus 0.8 to 2.2V to prepare the multi-walled carbon nano-tube-poly 4-(2-pyridyl-azo) resorcinol membrane modified electrode. The electrode is used for detecting the dopamine under the co-existence of ascorbic acid and uric acid, the result indicates that the electrode is capable of dividing the oxidation peak of ascorbic acid, dopamine and uric acid into three independent peaks with large distance, so that the interference of the co-existent ascorbic acid and uric acid on detection of the dopamine can be eliminated; the preparation and detection methods are high in sensitivity and good in reproducibility and stability.

Description

technical field [0001] The invention belongs to the field of electrochemistry, and in particular relates to a preparation and detection method of a chemically modified electrode for selectively measuring dopamine. Background technique [0002] Dopamine (DA), as the immediate precursor of norepinephrine, is a key neurotransmitter in the hypothalamus and pituitary gland, which has an important impact on the prevention, generation and control of many human diseases. [0003] At present, people mainly use spectrophotometry, high performance liquid chromatography, chemiluminescence, capillary electrophoresis, electrochemical methods and other methods to detect dopamine. Compared with other methods, electrochemical methods have the advantages of simple process, fast response time and sensitivity. High advantages, so it is widely used, but ascorbic acid (AA) and uric acid (UA) and dopamine often have very similar oxidation potentials on conventional electrodes, and the oxidation pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
Inventor 田冬梅赵琨戴诗岩
Owner SHENYANG NORMAL UNIV
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