Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anaerobic packing low-temperature and high-dosage-rate irradiation sterilization method of gelatin

A technology of irradiation sterilization and high dose rate, applied in packaging sterilization and other directions, can solve the problems of loss of application value, fragile capsules, and decreased viscosity, and achieve the effects of good capsule strength, good swelling and remarkable effect.

Inactive Publication Date: 2015-07-15
HUBEI UNIV OF SCI & TECH +1
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a low-temperature high-dose-rate radiation sterilization method for gelatin anaerobic packaging, which can solve the problem that the viscosity of gelatin decreases greatly after irradiation and the capsule is fragile, thereby reducing or losing the application value

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anaerobic packing low-temperature and high-dosage-rate irradiation sterilization method of gelatin
  • Anaerobic packing low-temperature and high-dosage-rate irradiation sterilization method of gelatin
  • Anaerobic packing low-temperature and high-dosage-rate irradiation sterilization method of gelatin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 (moisture control):

[0029] The low-temperature high-dose-rate irradiation sterilization method for gelatin anaerobic packaging comprises the following steps:

[0030] 1) Place MgCl in the inner bottom of the vacuum desiccator 2 , NH 4 NO 3 、KNO 3 Place the gelatin on the dividing plate, after balancing for 48h, record the water content of the gelatin with a moisture meter to be 4.64% (mass) (sample of the present invention), 8.64% (mass) (sample of the present invention) ), 18.22% (mass) (the sample of the comparative example). Take gelatin and the mode that water is directly and rapidly mixed in different proportions to obtain water content of 33%, 50%, 66% and 80% (mass) of gelatin (a total of 5 parts of gelatin of comparative examples, control different moisture).

[0031] Another portion of gelatin was air-dried at 50° C. to constant weight to obtain a sample with a water content of 0% (mass) (the sample of the present invention).

[0032] 2) Ge...

Embodiment 2

[0039] Embodiment 2 (low temperature pretreatment):

[0040] The low-temperature high-dose-rate irradiation sterilization method for gelatin anaerobic packaging comprises the following steps:

[0041] 1) The gelatin was air-dried at 50° C. to obtain three samples with a water content of 10% (mass);

[0042] 2) adopt polyethylene material bag to the gelatin of step 1), vacuumize;

[0043] 3) The packaged gelatin in step 2) was pre-cooled for 6 hours at 0°C (the sample of the present invention), 10°C (the sample of the present invention) and normal temperature (25°C, the comparative example) respectively, and then packaged in a thermal box;

[0044] 4) The gelatin pre-cooled and packaged in step 3) is irradiated with cobalt-60 source rays at a dose rate of 200Gy / min, and the absorbed dose is 6kGy.

[0045] 5) Step 4) The irradiated gelatin is checked by electron spin resonance instrument whether it has been irradiated. The ESR peak of the irradiated gelatin is 2 independent si...

Embodiment 3

[0050] Embodiment 3 (high dose rate irradiation):

[0051] The low-temperature high-dose-rate irradiation sterilization method for gelatin anaerobic packaging comprises the following steps:

[0052] 1) The method of drying at low temperature (25°C) is used to control the relative water content of the gelatin to be irradiated to be 0%;

[0053] 2) adopt polyethylene material bag to the gelatin of step 1), vacuumize;

[0054] 3) The packaged gelatin in step 2) is pre-cooled at 0°C for 6 hours, and then packed in an insulated box.

[0055] 4) to step 3) the gelatin of precooling outer packaging adopts the cobalt-60 source ray (sample of the present invention) of dose rate 60 (comparative example), 200Gy / min respectively and 10000Gy / min dose rate electron beam irradiation (the present invention) Invented sample), the absorbed dose is 8kGy;

[0056] 5) The irradiated gelatin in step 4) is tested for free radical properties by electron spin resonance.

[0057] The gelatin irradi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a sterilization method of gelatin, in particular to an anaerobic packing low-temperature and high-dosage-rate irradiation sterilization method of the gelatin. The method is characterized by comprising the following steps: (1) drying the gelatin at low temperature; (2) vacuumizing or carrying out anaerobic packing on the dried gelatin, wherein in the anaerobic packing process, N2 gas with volume of more than or equal to 75% or CO2 gas with volume of more than or equal to 75% is filled; (3) precooling the gelatin packaged in the step (2) for 6-12 hours at the temperature of 0-10 DEG C, wherein a heat preservation box is taken as external packing; (4) irradiating by one of the two methods, wherein one method comprises the steps of irradiating the gelatin which is precooled and packaged in the step (3) by a cobalt-60 source ray with the dosage rate of more than 200Gy / min to obtain the irradiated and sterilized gelatin, wherein the adsorbed dose range is 4-8kGy; the other method comprises the steps of irradiating the gelatin which is precooled and packaged in the step (3) by an electron beam with the dosage rate of more than 10000Gy / min to obtain the irradiated and sterilized gelatin, wherein the adsorbed dose range is 4-8kGy. The method solves the problem that the gel strength and the viscosity of the gelatin are greatly reduced after the gelatin is irradiated, so that the application value of the gelatin is reduced or lost.

Description

technical field [0001] The invention belongs to the field of agricultural product processing and preservation, and relates to a gelatin sterilization method, in particular to a low-temperature, high-dose-rate irradiation sterilization method for gelatin anaerobic packaging. Background technique [0002] Irradiation is a kind of physical, chemical and biological effects produced by the interaction between ionizing rays and substances to achieve the purpose of insecticide and sterilization. The two advantages of strong ray penetrating power and cold sterilization are especially suitable for disinfection and sterilization of tissue materials, medicines, and medical supplies, ensuring biological safety and extending shelf life. Irradiation is currently widely used as gelatin and capsule sterilization. It has been found in the application that negative effects often occur during the irradiation process, leading to problems such as decreased gelatin viscosity, fragile capsules, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B65B55/02
CPCB65B55/08
Inventor 耿胜荣陈洪国夏和舟程薇廖涛熊光权鉏晓艳李新邱建辉
Owner HUBEI UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com