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Application of giant salamander mucus in preparation of adhesive

A giant salamander mucus and adhesive technology, which is applied in the fields of application, surgical adhesives, and medical science, can solve tissue toxicity and other problems, and achieve the effect of light inflammation, good safety, and small scars

Inactive Publication Date: 2015-07-01
CHONGQING KUIXU BIOLOGICAL SCI & TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gelatin (derived from living organisms) is a class of tissue adhesives made with gelatin-resorcinol-formalin or gelatin-glutaraldehyde, although it provides high adhesion, formalin Or glutaraldehyde can cross-link with the protein of the target tissue, causing tissue toxicity

Method used

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  • Application of giant salamander mucus in preparation of adhesive
  • Application of giant salamander mucus in preparation of adhesive
  • Application of giant salamander mucus in preparation of adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The method for preparing an adhesive by utilizing giant salamander mucus comprises the following steps: placing the petri dish on which the giant salamander mucus is collected at -80°C overnight to freeze it into a solid state, and then using a vacuum freeze dryer at a vacuum degree of 19pa and a temperature of -50°C Freeze and vacuum-dry for 48 hours; then mash the freeze-dried giant salamander mucus and put it in a low-temperature ultrafine pulverizer to pulverize to 300 mesh, and finally grind it to 5×10 4 Gy dose of 60Co gamma ray irradiation sterilization to obtain tissue adhesive, aseptic packaging for future use. Among them, the temperature of low-temperature pulverization should be lower than 37°C, and the superfine pulverization effect of adding liquid nitrogen is the best.

Embodiment 2

[0022] The method for preparing an adhesive by using giant salamander mucus comprises the following steps: placing the petri dish on which the giant salamander mucus is collected at -20°C overnight to freeze it into a solid state, and then using a vacuum freeze dryer at a vacuum degree of 10 Pa and a temperature of -70°C Freeze and vacuum dry for 56 hours; then mash the freeze-dried giant salamander mucus and put it in a low-temperature ultrafine pulverizer to pulverize to 500 mesh, and finally grind it with 5×10 4 Gy dose of 60Co gamma ray irradiation sterilization to obtain tissue adhesive, aseptic packaging for future use. Among them, the temperature of low-temperature pulverization should be lower than 37°C, and the superfine pulverization effect of adding liquid nitrogen is the best.

Embodiment 3

[0024] The method for preparing an adhesive from the giant salamander mucus comprises the following steps: directly placing the petri dish for collecting the giant salamander mucus in a vacuum drying oven, drying it under vacuum at 37° C. for 48 hours, and then mashing the dried giant salamander mucus and placing it into a low-temperature ultrafine pulverization Machine crushed to 1000 mesh, finally with 2×10 4 Gy dose of 60Co gamma ray irradiation sterilization to obtain tissue adhesive, aseptic packaging for future use. Among them, the temperature of low-temperature pulverization should be lower than 37°C, and the superfine pulverization effect of adding liquid nitrogen is the best.

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Abstract

The invention discloses an application of giant salamander mucus in preparation of adhesive. The characteristic of strong adhesion property of the giant salamander mucus after being prepared into freeze-dried powder is fully used, and the adhesive is prepared from the giant salamander mucus which is a degradable natural ingredient with high safety and has better biocompatibility, so that the adhesive can be used as a tissue adhesive, and a new material is provided for medical wound surface adhesion, tissue adhesion, organ adhesion, and so on.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to the application of giant salamander mucus in preparing adhesives. Background technique [0002] Adhesives are sticky substances that join two separate materials together by virtue of their adhesive properties. According to the source of raw materials, it can be divided into natural adhesives and artificial adhesives. Tissue adhesive refers to the ability to polymerize in the body, thereby initiating the adhesion between tissues or between tissues and non-tissues (such as implants), and has the functions of controlling bleeding (hemostasis) and preventing the flow of gases and liquids (sealing). A class of biological materials. Compared with traditional clinical fixation and suture materials or instruments (such as sutures, rivets, etc.), tissue adhesives have the advantages of convenient use, less trauma, less pain during use, no need to remove after surgery, and...

Claims

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Application Information

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IPC IPC(8): A61L24/00
Inventor 商海涛王莹陈兵苟强魏泓邢孟秋周明辉
Owner CHONGQING KUIXU BIOLOGICAL SCI & TECH
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