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Suspension containing lincomycin and salinomycin sodium salt and preparation method thereof

A technology of salinomycin sodium and lincomycin, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, emulsion delivery, etc., and can solve problems such as narrow safety range and use restrictions

Inactive Publication Date: 2015-06-24
QINGDAO KDN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can also be used as a growth-promoting agent for pigs, but its safety range is narrow and its use is restricted

Method used

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  • Suspension containing lincomycin and salinomycin sodium salt and preparation method thereof

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example

[0021] Example: 5% Lincomycin, Salinomycin Sodium Suspension

[0022] [Prescription] Lincomycin, salinomycin sodium 5+15%(W / V)

[0023] Tragacanth 0.8%(W / V)

[0024] Propylene glycol 10%(W / V)

[0025] Poloxamer 0.3%(W / V)

[0026] Sodium benzoate 0.2%(W / V)

[0027] Pure water add to 100% (V / V)

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Abstract

The invention belongs to the technical field of an suspending agent liquid used for animal and a preparation method, and concretely relates to a suspension containing lincomycin and salinomycin sodium salt and a preparation method thereof. The suspension comprises the following components: a) lincomycin and salinomycin sodium salt bulk drugs; b)a suspending agent; c)a wetting agent; d)an antiseptic and e)an antiseptic. The suspension containing lincomycin and salinomycin sodium salt is prepared by employing a dispersion method, property of the suspension is characterized in that the suspension is white and viscous. The suspension containing lincomycin and salinomycin sodium salt has the advantages of good stability, good palatability, long elimination half life and high bioavailability, and can be used as an oral preparation for animal.

Description

Technical field [0001] The invention belongs to the technical field of veterinary analgesics and preparation methods, and particularly relates to a preparation method of a suspension of lincomycin and salinomycin sodium. [0002] technical background [0003] Lincomycin, the English name Lincomycin. Acts on the 50S subunit of the ribosome of sensitive bacteria to prevent the extension of the pus chain, thereby inhibiting the protein synthesis of bacterial cells. Salinomycin is a polyether antibiotic extracted from the culture broth of Streptomyces albus. It is a white or light yellow crystalline powder with a slight peculiar smell. This product is easily soluble in methanol, ethanol, acetone, ether, chloroform, slightly soluble in n-hexane, but insoluble in water. [0004] Salinomycin is a monovalent polyether ionophore antibiotic. Its anti-coccidial effect is roughly similar to monensin. It can also be used as a pig growth promoter, but the safety range is narrow and its use i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K9/10A61P31/04A61P33/02A61K31/351
Inventor 姚德勇
Owner QINGDAO KDN BIOTECH
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