Nonmagnetic biomedical implant material and preparation method thereof

A technology for biomedical and implant materials, applied in the field of medical implant materials and their preparation, can solve problems such as slow degradation rate, and achieve the effects of short production cycle, effective and convenient degradation rate, and wide application range

Active Publication Date: 2015-06-17
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The slow degradation rate of iron is one of the main limiting bottlenecks for its use as a biodegradable biomaterial

Method used

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  • Nonmagnetic biomedical implant material and preparation method thereof
  • Nonmagnetic biomedical implant material and preparation method thereof
  • Nonmagnetic biomedical implant material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Single-phase austenitic steel is selected, and its chemical composition mass percentage is: C: 0.6%, Mn: 13%, Si: 0.5%, Ca: 0.5%, Zn: 0.5%, Ag: 0.5%, S: 0.016 %, P: 0.022%, the rest is Fe. The single-phase austenitic steel with the above composition is subjected to three passes of liquid nitrogen cold rolling. Before each pass, the single-phase austenitic steel is placed in liquid nitrogen for 10 minutes. The ratio is: 10:1. The reductions in the three rolling passes were 10%, 8%, and 2% respectively, and the total reduction was 20%. Then perform secondary annealing treatment: heat up to 200°C at a rate of 5°C / min, hold for 60 minutes, and cool with the furnace. After the single-phase austenitic steel returns to room temperature, heat up to 600°C at a rate of 30°C / min. Keeping the temperature for 20 minutes and cooling with the furnace, the non-magnet-based biomedical implant material is prepared.

[0019] Depend on figure 1 It can be seen that the single-phase aust...

Embodiment 2

[0021] Single-phase austenitic steel is selected, and its chemical composition mass percentage is: C: 1.5%, Mn: 35%, Si: 0.6%, Ca: 2%, Zn: 2%, Ag: 2%, S: 0.020 %, P: 0.025%, the rest is Fe. The single-phase austenitic steel with the above composition is subjected to three passes of liquid nitrogen cold rolling. The ratio is: 50:1. The reductions in the three rolling passes are respectively 20%, 15%, and 5%, and the total reductions are 40%. Then perform secondary annealing treatment: heat up to 300°C at a rate of 40°C / min, hold for 180 minutes, and cool with the furnace. After the single-phase austenitic steel returns to room temperature, heat up to 800°C at a rate of 40°C / min. Keeping the temperature for 40 minutes and cooling with the furnace, the non-magnet-based biomedical implant material is prepared.

[0022] Depend on figure 2 It can be seen that the corrosion rate of the single-phase austenitic steel after 40% liquid nitrogen cold rolling and secondary annealing i...

Embodiment 3

[0024] Single-phase austenitic steel is selected, and its chemical composition mass percentage is: C: 1.0%, Mn: 25%, Si: 0.55%, Ca: 1%, Zn: 1%, Ag: 1%, S: 0.018 %, P: 0.023%, the rest is Fe. The single-phase austenitic steel with the above composition is subjected to three passes of liquid nitrogen cold rolling. The ratio is: 30:1. The reductions in the three rolling passes were 15%, 10%, and 4% respectively, and the total reduction was 29%. Then perform secondary annealing treatment: heat up to 250°C at a rate of 20°C / min, hold for 100 minutes, and cool with the furnace. After the single-phase austenitic steel returns to room temperature, heat up to 700°C at a rate of 35°C / min. Keeping the temperature for 25 minutes and cooling with the furnace, the non-magnet-based biomedical implant material is prepared.

[0025] Depend on image 3 It can be seen that the corrosion current density of single-phase austenitic steel after 29% liquid nitrogen cold rolling and secondary anne...

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Abstract

A nonmagnetic biomedical implant material is single phase austenite, and comprises 0.6-1.5wt% of C, 13-35wt% of Mn, 0.5-0.6wt% of Si, 0.5-2wt% of Ca, 0.5-2wt% of Zn, 0.5-2wt% of Ag, 0.016-0.020wt% of S, 0.022-0.025wt% of P, and the balance of Fe. A preparation method of the nonmagnetic biomedical implant material comprises the following steps: carrying out three-pass liquid nitrogen cold rolling on the above single phase austenite steel with the press amounts of 10-20%, 8-15% and 2-5% respectively; and carrying out two-stage annealing treatment: heating at a rate of 5-40DEG C/min to 200-300DEG C, carrying out heat insulation for 60-180min, cooling in a furnace, heating at a rate of 30-40DEG C/min to 600-800DEG C, carrying out heat insulation for 20-40min, and cooling in the furnace to prepare the nonmagnetic biomedical implant material. The nonmagnetic biomedical implant material has the advantages of short production period, low cost, and obviously improved integral degradation rate.

Description

technical field [0001] The invention relates to a degradable metal material, in particular to a medical implant material and a preparation method thereof. Background technique [0002] At present, the hot research on degradable metal materials mainly focuses on pure magnesium and magnesium-based metal alloys, and pure iron and iron-based metal alloys. Compared with magnesium-based alloys, pure iron and its alloys have excellent mechanical properties, and no hydrogen evolution reaction occurs during the degradation process. In addition, Fe is also an extremely important trace element in the human body. Relevant experimental studies have shown that pure iron or iron alloys have certain biological safety as implants. Better biocompatibility is also a major advantage of pure iron and its alloys. According to some current research results, including in vitro blood experiments, cytotoxicity experiments and animal experiments on pure iron and iron alloys, it has been shown that it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C38/04C21D8/00C21D6/04
Inventor 彭秋明王雅楠张志伟
Owner YANSHAN UNIV
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