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Method for removing anti-depressive drug, namely amitriptyline, in water body

A technology for amitriptyline and antidepressants, which is applied in the field of removing antidepressant amitriptyline in water, can solve the problems of high cost, poor removal rate, inconvenient use, etc., and achieves fast speed and low price , easily obtained effect

Inactive Publication Date: 2015-06-17
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the problems that existing methods for removing antidepressants in water have high cost, poor removal rate, and inconvenient use, and provide a method for removing antidepressants amitriptyline in water Methods

Method used

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Effect test

specific Embodiment approach 1

[0019] Specific embodiment one: take the amitriptyline aqueous solution that initial concentration is 10mg / l, add 0.1mM H 2 o 2 Under the condition of ultraviolet light, the degradation rate of 60% can be reached in 120min; adding 0.1mM Fe alone 2+ Under certain conditions, a degradation rate greater than 90% can be achieved in 60 minutes.

specific Embodiment approach 2

[0020] Specific embodiment two: take the amitriptyline aqueous solution that initial concentration is 10mg / l, adjust pH to be 3.5, after adding H 2 o 2 :Fe 2+ When the ratio is 10:1 (0.1mM:0.01mM), it is determined by high performance liquid chromatography after being irradiated with ultraviolet light in a photochemical reaction instrument. Amitriptyline in the solution can reach a degradation rate greater than 95% within 20 minutes.

specific Embodiment approach 3

[0021] Specific embodiment three: H in embodiment 2 2 o 2 :Fe 2+ When changing to 1:1 (0.1mM:0.1mM), under ultraviolet irradiation, the degradation rate of more than 98% can be achieved in about 5 minutes. Depending on the concentration of amitriptyline, an appropriate concentration of Fenton's reagent can be selected.

[0022] Specific embodiment four: take the amitriptyline aqueous solution that initial concentration is 10mg / l, adjust pH to be 3.5, for verifying optimum ratio, under low dose Fenton's reagent condition, when H 2 o 2 :Fe 2+ When changing from 3:1 (0.03mM:0.01mM) to 1:1 (0.03mM:0.03mM), the degradation rate in 30 minutes increased from 39% to 82%.

[0023] Specific embodiment five: in embodiment 4, Fe 2+ Continue to increase, from 0.03mM to 0.05mM, the degradation rate only increased by 3%. From the consideration of reducing processing cost, adding Fenton's reagent H 2 o 2 :Fe 2+ The best ratio is between 1:1 and 3:1.

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Abstract

The invention relates to a method for removing an anti-depressive drug, namely amitriptyline, in a water body. The method disclosed by the invention aims to solve the problems that the existing method for removing the anti-depressive drug in the water body is higher in cost, poor in removing rate and inconvenient to use. The method comprises the following steps: adding a ferrous salt solution into a pre-treated water body containing amitriptyline, adjusting the pH value of the water body to be about 3.5, then, adding hydrogen peroxide, and irradiating by adopting an ultraviolet high-pressure mercury lamp after uniformly mixing. The method disclosed by the invention has the advantages that amitriptyline is finally degraded into a substance, which can be used as a medical intermediate, so that secondary pollution cannot be caused; the method is rapid in reaction rate, high in degrading efficiency, simple and easy to operate and moderate in reaction condition; reaction reagents (sulphite and hydrogen peroxide) are low in cost and easy to obtain; and the method disclosed by the invention can be used for removing residual amitriptyline in the water body.

Description

technical field [0001] The invention relates to a method for removing antidepressant amitriptyline in water. Background technique [0002] Amitriptyline is one of the tricyclic antidepressants commonly used clinically. It has a strong sedative effect and is mainly used for the treatment of neurological diseases such as anxiety or agitated depression, panic disorder, and the relief of chronic pain. Due to the large-scale production, use and discharge of amitriptyline in recent years, it has been detected as a new type of environmental pollutant in the surface water of many countries, which has attracted widespread attention. For example, Hailing-Sorensen et al. found that amitriptyline was detected in European surface waters, and multiple antidepressants were also detected in wastewater treatment system (WWTP) effluents in most EU countries. There are two main sources of amitriptyline in water bodies: one is the massive use of this drug by humans, and the other is the discha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C02F1/72C02F1/66C02F1/32C02F1/58
Inventor 杨明雷湘杰刘帅胡磊李意捷吴明红
Owner SHANGHAI UNIV
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