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Cefradine capsule and preparation method thereof

A technology for cefradine and capsules, applied in the field of cefradine capsules and their preparation, can solve the problems of unsuitable wet granulation, unstable chemical properties, high temperature sensitivity, etc., so as to overcome poor fluidity, improve fluidity and lubricating effects , the effect of improving stability

Inactive Publication Date: 2015-06-10
JIANGSU YABANG QIANGSHENG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Cefradine is a β-lactam antibiotic with unstable chemical properties, easy hydrolysis, and high temperature sensitivity, so wet granulation technology should not be used

Method used

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  • Cefradine capsule and preparation method thereof
  • Cefradine capsule and preparation method thereof
  • Cefradine capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of cephradine capsule, its prescription is composed as follows:

[0024]

[0025] Preparation:

[0026] (1) Drying: Dry part of the pregelatinized starch and microcrystalline cellulose in a hot air circulation oven at 100±5°C for 2 hours;

[0027] (2) sieving: cross 20 mesh sieves with cephradine and magnesium stearate, and cross 40 mesh sieves after drying microcrystalline cellulose and part of pregelatinized starch;

[0028] (3) Mixing: Weigh the powder of each raw and auxiliary material obtained in step (2) according to the prescription amount, mix cephradine, microcrystalline cellulose and part of pregelatinized starch in a mixer for 20 minutes, mix well, and then add Magnesium stearate, mixed for 5 minutes, to obtain the contents required for filling the capsule;

[0029] (4) flush filling: the content that step (3) is made is packed in the hollow capsule by filling capacity, and the difference of control filling capacity is within ± 10%, makes cephradi...

Embodiment 2

[0032] A kind of cephradine capsule, its prescription is composed as follows:

[0033]

[0034] Preparation:

[0035] (1) Drying: Dry part of the pregelatinized starch and microcrystalline cellulose in a hot air circulation oven at 100±5°C for 2 hours;

[0036] (2) sieving: cross 20 mesh sieves with cephradine and magnesium stearate, and cross 40 mesh sieves after drying microcrystalline cellulose and part of pregelatinized starch;

[0037] (3) Mixing: Weigh the powder of each raw and auxiliary material obtained in step (2) according to the prescription amount, mix cephradine, microcrystalline cellulose and part of pregelatinized starch in a mixer for 20 minutes, mix well, and then add Magnesium stearate, mixed for 5 minutes, to obtain the contents required for filling the capsule;

[0038] (4) flush filling: the content that step (3) is made is packed in the hollow capsule by filling capacity, and the difference of control filling capacity is within ± 10%, makes cephradi...

Embodiment 3

[0041] A kind of cephradine capsule, its prescription is composed as follows:

[0042]

[0043] Preparation:

[0044] (1) Drying: Dry part of the pregelatinized starch and microcrystalline cellulose in a hot air circulation oven at 100±5°C for 2 hours;

[0045] (2) sieving: cross 20 mesh sieves with cephradine and magnesium stearate, and cross 40 mesh sieves after drying microcrystalline cellulose and part of pregelatinized starch;

[0046] (3) Mixing: Weigh the powder of each raw and auxiliary material obtained in step (2) according to the prescription amount, mix cephradine, microcrystalline cellulose and part of pregelatinized starch in a mixer for 20 minutes, mix well, and then add Magnesium stearate, mixed for 5 minutes, to obtain the contents required for filling the capsule;

[0047] (4) flush filling: the content that step (3) is made is packed in the empty capsule by filling capacity, and the difference of control filling capacity is within ± 7.5%, makes cephradi...

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Abstract

The invention provides a cefradine capsule and a preparation method thereof. The capsule comprises the following components in weight percentage: 70-90 wt% of cefradine, 5-15 wt% of partial pregelatinized starch, 5-15 wt% of microcrystalline cellulose and 0.1-1 wt% of magnesium stearate. The components in the capsule have good compatibility; the prepared cefradine capsule is good in dissolution and high in stability; the provided preparation method is simple in process and easy in quality control.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cephradine capsule and a preparation method thereof. Background technique [0002] Cephalosporin antibiotics are semi-synthetic antibiotics made by attaching different side chains to the 7-aminocephalosporanic acid (7-ACA) core of cephalosporins. This class of antibiotics has the advantages of broad antibacterial spectrum, strong bactericidal power, stability to gastric acid and β-lactamase, and less allergic reactions. According to their antibacterial characteristics and different clinical applications, they can be divided into four generations of cephalosporins. [0003] Cephradine belongs to the first-generation cephalosporins. It is a white or off-white crystalline powder with a slight odor. It is slightly soluble in water and almost insoluble in ethanol, chloroform and ether. Its structural formula is as follows: [0004] [0005] Cephradine has good acid...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/545A61K47/38A61P31/04
Inventor 刘雯陈再新赵晓红王思清盖海涛王玉平郭文张卫东丁旭
Owner JIANGSU YABANG QIANGSHENG PHARMA
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