Chemical structure and preparation method of 99mTc-labeled RGD polypeptide trimer tumor imaging agent
A peptide trimer, 99mtc-4p-rgd3 technology, applied in the direction of radioactive carriers, can solve the problems of high radioactive background, interference with the imaging effect of tumor parts in abdominal organs, and high uptake value of non-target organs
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[0016] RGD polypeptide trimer single-photon radiopharmaceutical preparation method:
[0017] 1. Materials and instruments: Purified chemical reagents were purchased from Sigma / Aldrich Company in the United States (St.Louis, MO). RGD polypeptide trimer (4P-RGD 3 ) is specially customized to Peptides International, Inc of the United States (Louisville, KY). HYNIC-Osu was formulated according to the method described in the literature. MALDI (matrix-assisted laser desorption ionization) mass spectrometry data were collected by Applied Biosystems Voyager DE PRO mass spectrometer (Framingham, MA). 99m TCO 4 - Obtained through drug dealers.
[0018] 2. HPLC (high performance liquid chromatography) analysis method:
[0019] 1. Method 1: the semi-preparative high-performance liquid chromatography (HPLC) analysis method used is equipped with the LabAlliance high-performance liquid chromatography analysis system and the Zorbax C18 semi-preparative chromatographic column (9.4nm ×25...
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