A kind of preparation method of compound Houttuynia cordata film-coated tablet

Abstract

The invention discloses a method for preparing compound houttuynia cordata thin membrane coated tablets. The method comprises the following steps: (1) performing raw material treatment, namely taking the following five medicines in parts by weight: 583 parts of houttuynia cordata, 150 parts of radix scutellariae, 150 parts of radix isatidis, 58 parts of fructus forsythiae and 58 parts of honeysuckle flower, grinding 200 parts of houttuynia cordata, fructus forsythiae and honeysuckle flower into fine powder, grinding and mixing the residual houttuynia cordata, radix scutellariae and radix isatidis, adding water in an amount being three times of the amount of the mixture, ultrasonically extracting for 30 minutes, centrifuging, adding water in an amount being two times of the amount of decoction dregs into the decoction dregs, ultrasonically extracting for 30 minutes, centrifuging, merging the decoction, filtering, and concentrating the filtrate into thick paste; (2) tabletting, namely preparing the fine powder, thick paste and auxiliary materials into granules, drying, and tabletting into compressed-tablets; and (3) coating, namely adding the compressed-tablets into a coating pan, and performing trundle pan coating until the coating solution is sprayed completely, wherein the amount of the coating solution is 0.02-0.05 weight part, and the coating solution comprises the following components in percentage by weight: 10-15 percent of carboxymethylcellulose sodium, 10-15 percent of Momordica grosvenori extract, 1-3 percent of microcrystalline cellulose, 0.1-0.5 percent of guar gum and the balance of purified water.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of compound Houttuynia cordata film-coated tablets. Background technique [0002] Pharmaceutical coating is to spray a thin film with good stability on the tablet embryos pressed from raw materials to cover up the taste of the drug tablet itself and increase the stability of the tablet, avoiding chemically active drugs and other substances Deterioration due to chemical reaction, etc. The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients accessories. Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight ga...

AI Technical Summary

Problems solved by technology

The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients Accessories

Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more than 70%), and it is prone to mottling, discoloration, lobes, etc., and it cannot be packaged. Enteric-coated tablets