Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ampicillin sodium sulbactam sodium preparation for injection and preparation method thereof

A technology of ampicillin sodium sulbactam sodium and ampicillin sodium, which is applied in the field of medicine, can solve problems such as poor stability, easy allergies, and many impurities, and achieve the effects of good stability, increased reaction yield, and high purity

Inactive Publication Date: 2015-05-27
NORTH CHINA PHARMA COMPANY +2
View PDF6 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Current Ampicillin Sodium Sulbactam Sodium for Injection has the disadvantages of low purity, many impurities, poor stability, and easy allergies.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ampicillin sodium sulbactam sodium preparation for injection and preparation method thereof
  • Ampicillin sodium sulbactam sodium preparation for injection and preparation method thereof
  • Ampicillin sodium sulbactam sodium preparation for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] An ampicillin sodium sulbactam sodium preparation for injection is prepared by uniformly mixing high-purity ampicillin sodium and high-purity sulbactam sodium, and the weight ratio of ampicillin sodium to sulbactam sodium is 2:1.

[0044] The ampicillin sodium sulbactam sodium preparation for injection is prepared by the following steps:

[0045] (1) prepare high-purity ampicillin sodium; this high-purity ampicillin sodium is prepared with the following method:

[0046] ① Preparation of mixed acid anhydride: add 906ml of dichloromethane, add 298 grams of L-phenylglycine ethyl Deng potassium salt (Deng salt) under rapid stirring, add 130ml N, N-dimethylacetamide (DMA) at the same time, keep the temperature at 10- 15°C, cool down, when the temperature drops to 0°C, add 7.5 grams of 2,6-lutidine, continue to cool down to -30°C, add 119 grams of pivaloyl chloride at a uniform speed within 10 minutes, and control the temperature at -15°C, The reaction was incubated for 60 m...

Embodiment 2

[0060] An ampicillin sodium sulbactam sodium preparation for injection is prepared by uniformly mixing high-purity ampicillin sodium and high-purity sulbactam sodium, and the weight ratio of ampicillin sodium to sulbactam sodium is 3:1.

[0061] The ampicillin sodium sulbactam sodium preparation for injection is prepared by the following steps:

[0062] (1) prepare high-purity ampicillin sodium; this high-purity ampicillin sodium is prepared with the following method:

[0063] ① Preparation of mixed acid anhydride: add 1000ml of dichloromethane, add 298 grams of L-phenylglycine ethyl Deng potassium salt (Deng salt) under rapid stirring, and add 150ml N,N-dimethylacetamide (DMA) at the same time, keep the temperature at 10- 15°C, lower the temperature, when the temperature drops to 0°C, add 8.2 grams of 2,6-lutidine, continue to cool down to -34°C, add 125 grams of pivaloyl chloride at a uniform speed within 10 minutes, and control the temperature at -18°C, The reaction was in...

Embodiment 3

[0077] An ampicillin sodium sulbactam sodium preparation for injection is prepared by uniformly mixing high-purity ampicillin sodium and high-purity sulbactam sodium, and the weight ratio of ampicillin sodium to sulbactam sodium is 4:1.

[0078] The ampicillin sodium sulbactam sodium preparation for injection is prepared by the following steps:

[0079] (1) prepare high-purity ampicillin sodium; this high-purity ampicillin sodium is prepared with the following method:

[0080] ① Preparation of mixed acid anhydride: Add 1132ml of dichloromethane, add 298 grams of L-phenylglycine ethyl Deng potassium salt (Deng salt) under rapid stirring, add 160ml N, N-dimethylacetamide (DMA) at the same time, keep the temperature at 10- 15°C, lower the temperature, when the temperature drops to 0°C, add 9.0 grams of 2,6-lutidine, continue to cool down to -38°C, add 131 grams of pivaloyl chloride at a uniform speed within 10 minutes, and control the temperature at -20°C, The reaction was incub...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an ampicillin sodium sulbactam sodium preparation for injection and a preparation method thereof. The ampicillin sodium sulbactam sodium preparation for injection is formed by mixing high-purity ampicillin sodium crystals with high-purity sulbactam sodium uniformly, wherein the weight ratio of ampicillin sodium to sulbactam sodium is (2-4):1. The ampicillin sodium sulbactam sodium preparation for injection has the advantages of high purity, less impurity, high stability, difficult irritability and the like.

Description

technical field [0001] The invention relates to an ampicillin sodium sulbactam sodium preparation for injection and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Ampicillin sodium and sulbactam sodium for injection are compound preparations, and its components are sterile powders uniformly mixed with ampicillin sodium and sulbactam sodium. [0003] Ampicillin sodium, chemical name: (2S, 5R, 6R)-3,3-dimethyl-6[ -2-Amino-2-phenylacetamido]-7-oxo-4-thioxo-1-amobicyclo[3.2.0]heptane-2-potassium acid sodium salt. Molecular formula: C 16 h 18 N 3 NaO 4 S, molecular weight: 371.39. Ampicillin sodium is one of the earliest semi-synthetic penicillin antibiotics, suitable for the treatment of infections caused by sensitive bacteria. Typical indications include: sinusitis, otitis media, epiglottitis, bacterial pneumonia and other upper and lower respiratory tract infections; urinary tract infection, pyelonephritis; per...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/43A61K9/14A61P31/04C07D499/68C07D499/86C07D499/16
Inventor 左丽华严正人胡卫国郝瑞霞王欣王利杰刘丹杨京霞李颜茹陈宇东傅苗青胡国胜
Owner NORTH CHINA PHARMA COMPANY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com