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Biomaterial for repairing osseous tissues and preparation method of biomaterial

A biomaterial and bone tissue technology, applied in medical science, prostheses, etc., can solve the problems of poor performance of hydroxyapatite biomaterials, unfavorable popularization and application, and complicated preparation methods, so as to promote biological compatibility, The effect of easy collection and simple preparation process

Active Publication Date: 2015-05-20
徐州博创建设发展集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current biomaterials used to stably generate hydroxyapatite in organisms have poor performance, complicated preparation methods, high energy consumption, and high product costs, which are not conducive to popularization and application.

Method used

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  • Biomaterial for repairing osseous tissues and preparation method of biomaterial
  • Biomaterial for repairing osseous tissues and preparation method of biomaterial
  • Biomaterial for repairing osseous tissues and preparation method of biomaterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] According to the chemical formula Ca 2 Mg 5 (Si 4 o 11 ) 2 f 2 The molar ratio of each element in, respectively weigh calcium carbonate CaCO 3 : 0.333 g, magnesium basic carbonate 4MgCO 3 ·Mg(OH) 2 ·5H 2 O: 1.619 g, silicon dioxide SiO 2 : 1.603 g, calcium fluoride CaF 2 : 0.338g, ground in an agate mortar and mixed evenly, pre-calcined in air atmosphere, pre-calcined at 250°C, pre-calcined for 14 hours, then cooled to room temperature, and the sample was taken out; the pre-calcined raw materials were fully mixed and ground again Uniform, calcined again in air atmosphere, calcined temperature 950 ° C, calcined time 8 hours, cooled and ground to get Ca 2 Mg 5 (Si 4 o 11 ) 2 f 2 Powder.

[0041] Prepared Ca 2 Mg 5 (Si 4 o 11 ) 2 f 2 The powder was soaked in simulated body fluid for 1 day, 5 days and 10 days, and the changes of surface morphology at different mineralization times were observed to judge the Ca 2 Mg 5 (Si 4 o 11 ) 2 f 2 Whether th...

Embodiment 2

[0052] According to the chemical formula Ca 2 Mg 5 (Si 4 o 11 ) 2 f 2 The molar ratio of each element in the formula is weighed respectively calcium oxide CaO: 0.1869 grams, magnesium oxide MgO: 0.6717 grams, calcium fluoride CaF 2 : 0.338 grams, respectively dissolved in nitric acid, and diluted with deionized water, constantly stirred, then respectively weighed 0.5wt% oxalic acid of each raw material quality and added to the solution respectively, and stirred, weighed ethyl orthosilicate Ester Si(OC 2 h 5 ) 4 : 5.556 grams, and add an equal volume of ethanol and 5 times the volume of nitric acid solution in tetraethyl orthosilicate, dilute with deionized water, and carry out stirring treatment. After completely dissolving, the above-mentioned various solutions are mixed, and Heating and stirring at 40°C for 3 hours, standing and drying to obtain a fluffy precursor; placing the precursor in a muffle furnace for calcination at a calcination temperature of 600°C for 10 ...

Embodiment 3

[0057] According to the chemical formula Ca 2 Mg 5 (Si 4 o 11 ) 2 f 2 The molar ratio of each element in , respectively weigh calcium sulfate CaSO 4 2H 2 O: 0.4538 g, magnesium chloride MgCl 2 : 1.587 g, silicon dioxide SiO 2 : 1.603 grams, magnesium fluoride: 0.5205 grams, ground in an agate mortar and mixed evenly, select the air atmosphere for pre-calcination, pre-calcination temperature 700 ℃, pre-calcination time 2 hours, then cool to room temperature, take out the sample; The calcined raw materials are fully mixed and ground again, and calcined again in the air atmosphere, the calcining temperature is 900°C, the calcining time is 10 hours, cooling and grinding to obtain Ca 2 Mg 5 (Si 4 o 11 ) 2 f 2 Powder.

[0058] Weigh 2 grams of powder, dry press molding under 10MPa to make a ceramic green body with a diameter of 20 mm and a thickness of 2 mm; the ceramic green body is sintered at 950 ° C for 2 hours to prepare a ceramic disc.

[0059] Soak the prepared...

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Abstract

The invention discloses a biomaterial for repairing osseous tissues and a preparation method of the biomaterial. A chemical formula of the biomaterial is Ca2Mg5(Si4O11)2F2. The method comprises the following steps: selecting compounds containing elements required for synthesis of the biomaterial according to the ratio; calcining for many times, or dissolving with a chemical solution, mixing and then calcining to prepare the material; mineralizing the prepared Ca2Mg5(Si4O11)2F2 powder or Ca2Mg5(Si4O11)2F2 ceramic blocks in a simulated body fluid for a period of time, then depositing a large amount of bone-like apatite layer on the surface. The biomaterial has relatively good biological activity and can be applied to repairing of osseous tissues. The prepared biomaterial has good biological activity and mechanical property; the mechanical property is close to that of a cortical bone of a human body; the biomaterial is an ideal biological and medical material, can be used as a repairing material for a non-bearing bone part; the required raw materials are abundant; the preparation method is simple, flexible, and easy to operate; the product is easy to collect; energy consumption and product cost are low.

Description

technical field [0001] The invention relates to a biological material for bone tissue repair and a preparation method thereof, belonging to the field of biological materials. Background technique [0002] With the rapid development of material science and medicine and the improvement of people's living standards, medical care, and rehabilitation, people's requirements for the repair and replacement of human organs and fracture defects are increasing day by day. According to statistics, in recent years, the number of patients with arthritis and other diseases has increased year by year. In the United States, about 500,000 people undergo surgery every year to replace hips, shoulders, elbows, and knees with artificial joints. There are many types of artificial joints, the appearance and shape are complex, and the joint size of each patient is different. At present, artificial joints are mainly produced in series. In most cases, the artificial joint stem cannot form a close ana...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/50C04B35/16C04B35/626
Inventor 乔学斌
Owner 徐州博创建设发展集团有限公司
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