Application of E-10-hydroxy-2-decenoic acid in medicines or health products for preventing and treating chemical liver injuries

Abstract

The invention discloses a novel application of E-10-hydroxy-2-decenoic acid, specifically discloses an applicationof E-10-hydroxy-2-decenoic acid in medicines or health products for preventing and treating chemical liver injuries, and belongs to the technical field of prevention and treatment of chemical liver injuries. E-10-hydroxy-2-decenoic acid has a specific liver protecting effect, can be applied to medicines or health products for preventing and treating the chemical liver injuries, and has the advantages of low cost, good effect, low dosage and no toxic or side effect.

Description

Technical field [0001] The invention involves the field of chemical liver injury prevention and control technology. Background technique [0002] Liver disease caused by drugs accounts for 20%to 50%of non -viral liver disease. In my country's liver disease, the incidence of drug -induced liver injury is second only to viral hepatitis and fatty liver diseases (including alcoholic and non -alcoholic). The incidence rate, but due to the difference in clinical manifestations or hidden, it is often not found or confirmed.At present, there are more than 1,000 drugs that can clearly cause drug -based liver injuries in the drug or health products we have contacted in daily life. Therefore, medicinal liver injury has become a serious public health problem that cannot be ignored. [0003] Chemicals (drugs, ethanol, haze, fat polysaccharides, plant condensate such as bladed bean protein, etc.), re -oxidation (reperfusion) and acute chronic disease reactions after hypoxia can cause oxidized ...

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Problems solved by technology

[0008] Non-patent literature "Experimental study on the prevention and treatment of liver fibrosis in rats with 10-carboxy-2-decenoic acid and royal jelly" (Ru Qingjing et al., Journal of Integrative Traditional Chinese and Western Medicine Hepatology , 2010, 20(3), 168-170) only reported the therapeutic effect and mechanism of royal jelly acid and royal jelly on rat liver fibrosis; non-patent literature "Research progress and prospect of 10-carboxy-2-decenoic acid" (He Chunling et al., China Agricultural Science Bulletin, 2007, 23(6), 227-231) reviewed the research results of the application of royal jelly acid before 2007, and introduced the effects of royal jelly acid on enhancing immunity, suppressing cancer, antibacterial and anti-inflammatory, radiation protection, and reducing inflammation. Research results on the physiological effects of blood lipids; the non-patent literature "Research Progress of Royal Jelly Acid" (Zhang Yanbin et al., China Agricultural Science Bulletin, 2013, 41 (5), 20-22) reviewed the synthesis and application of royal jelly acid before 2013, The physiological effects described are consistent with the non-patent literature "Research Progress and Prospects of 10-Carboxy-2-Decenoic Acid", which does not mention the application of royal jelly acid in the treatment or auxiliary treatment of liver damage caused by alcohol, drugs and other chemical substances ; The non-patent literature "Research on Active Components of Royal Jelly and Liver-Protecting Mechanism" (Ru Qingjing et al., Journal of Integrated Traditional Chinese and Western Medicine Hepatology, 2002, 12(6), 381-383) reviewed the liver-protecting mechanism of active components of royal jelly before 2002 , the core of which is the protective effect of proteins, sugars, vitamins, trace elements and trace substances (such as SOD, etc.) in royal jelly on the liver. Although 10-HDA is mentioned in the article, it is only from the perspective of immune regulation, reducing the side effects of chemotherapy drugs, anti-cancer and other aspects to describe

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