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Preparation method and application of medical tea oil

A technology of camellia oil and injection oil, which is applied in the fields of fat oil/fat refining, fat oil/fat production, oil/fat/wax non-active ingredients, etc. It can solve the problem of threatening the life safety of patients, triggering body pyrogen reaction, and affecting product quality And other problems, to save the effect of low temperature winterization

Inactive Publication Date: 2015-05-13
GANNAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a kind of salad oil, the refined camellia oil has good appearance and transparency when the temperature is high, but when the temperature is close to 0°C in winter, flocculent floating matter (according to the test is solid fat) may appear, thus Seriously affect the quality of the product
Studies have found that injections made of oils containing impurities can trigger pyrogenic reactions in the body, seriously threatening the lives of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for preparing medical camellia oil, the preparation method comprising the following steps: ① fine extraction: shelling camellia seeds, drying at 75°C to constant weight, pulverizing and sieving to control particle size <0.8mm, and weighing camellia oleifera seeds Put the seed kernel powder into the supercritical extraction tank, set the pressure of the extraction tank to 30Mpa, the temperature to 40°C, and the pressure of the separation tank to 6Mpa. The re-purified CO2 is boosted to the set value, and it reaches the supercritical fluid state for extraction. After reaching the set condition, the extraction is continued for 2 hours, and the CO2 is gasified and recycled. The extract is released from the bottom of the separation tank to obtain tea oil essential oil ; ②Deacidification: Stir and heat the tea oil essential oil until the oil temperature rises to 75°C, dissolve KOH in soft water to make lye, quickly and evenly sprinkle it into the oil, mix thoroughly, s...

Embodiment 2

[0022] A method for preparing medical camellia oil, the preparation method comprising the following steps: ① fine extraction: shelling camellia seeds, drying at 70°C to constant weight, crushing and sieving to control particle size < 0.8mm, and weighing camellia oleifera seeds Put the seed kernel powder into the supercritical extraction tank, set the pressure of the extraction tank to 20Mpa, the temperature to 30°C, and the pressure of the separation tank to 6Mpa. The re-purified CO2 is boosted to the set value, and it reaches the supercritical fluid state for extraction. After reaching the set condition, the extraction is continued for 1 hour, and the CO2 is gasified and recycled. The extract is released from the bottom of the separation tank to obtain tea oil essential oil; ② Deacidification: Stir and heat the tea oil essential oil. When the temperature of the oil rises to 75°C, dissolve KOH in soft water to make lye. Sprinkle it into the oil quickly and evenly, mix well, sto...

Embodiment 3

[0024]A method for preparing medical camellia oil, the preparation method comprising the following steps: ① fine extraction: shelling camellia seeds, drying at 70°C-80°C to constant weight, pulverizing and sieving to control particle size < 0.8mm, Weigh camellia seed kernel powder and put it into a supercritical extraction tank. Set the pressure of the extraction kettle to 35 Mpa, the temperature to 45°C, and the pressure of the separation tank to 7Mpa. CO2 preheated and repurified by the device, boosted to the set value, reached the supercritical fluid state for extraction, and continued to extract for 2 hours after reaching the set condition, CO2 was gasified and recycled, and the extract was released from the bottom of the separation tank. Obtain camellia essential oil; ② Deacidification: Stir and heat the camellia essential oil until the temperature of the oil rises to 75°C, dissolve KOH in soft water to make lye, sprinkle it into the oil quickly and evenly, mix well, and w...

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PUM

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Abstract

The invention relates to a preparation method and application of medical tea oil. The preparation method comprises the following steps: (1) performing refined extraction; (2) deacidifying, namely, agitating and heating tea essential oil, dissolving KOH with soft water to obtain an alkaline solution after the oil temperature raises to 70-75 DEG C, rapidly and uniformly spraying into soil, fully mixing, stopping agitating after nigre particles appear, heating to 80 DEG C, standing at the constant temperature for 12 hours to completely precipitate, transferring upper clear oil to a washing pot, heating the oil to 85 DEG C, adding hot water to wash, standing at the constant temperature for 1 hour, separating out the upper clear oil, and then dewatering and drying under a vacuum condition to obtain the deacidified oil; (3) discoloring; (4) deodorizing; and (5) fractionating. Compared with the prior art, the method focuses on the selection of technological conditions; the tea oil is heated to be 70 to 75 DEG C during deacidifying, then the alkaline solution is added, and the tea oil is precipitated at the constant temperature of 80 DEG C. The medical tea oil prepared under the technological conditions has the advantages that the fractionating is carried out at 19 to 21 DEG C, and the low-temperature winterization can be saved.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical excipients, and in particular relates to a preparation method and application of medical camellia oil. Background technique [0002] Camellia oil is edible oil extracted from wild camellia seeds, also known as camellia oil and camellia oil. The unsaturated fatty acid content of camellia oil is more than 85%, the content of vitamin A and E is high, and it is storage-resistant and easy to be absorbed by the human body. Camellia oil does not contain erucic acid which is harmful to the human body, and it can also prevent and treat high blood pressure and cardiovascular diseases. It is the best among edible vegetable oils. In industry, tea oil can be used to produce oleic acid and its esters, to produce soap and vaseline, etc., and also to produce stearic acid and glycerin. In medicine, tea oil can be used to make injections and prepare various ointments, pills, etc., and folks ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B1/10C11B3/00C11B3/06C11B3/10C11B3/16A61K47/44A61K31/4725
Inventor 范小娜丁治春韩立民刘霞
Owner GANNAN MEDICAL UNIV
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