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Tilmicosin enteric micro pellet

A technology of tilmicosin and enteric-coated pellets, which is applied to medical preparations of non-active ingredients, organic active ingredients, antibacterial drugs, etc., can solve problems such as bitter taste and limited masking effect, and achieve improved stability, Avoid waste and improve the effect of drug utilization

Inactive Publication Date: 2015-05-13
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention designs and develops a kind of tilmicosin enteric-coated pellets, which solves the problem that the traditional bitterness masking technology has limited masking effect and is difficult to really cover up the bitterness, and improves the stability of tilmicosin in acid without affecting animal collection. Food intake, to better meet the needs of production

Method used

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  • Tilmicosin enteric micro pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Composition of tilmicosin pellet core:

[0020] Tilmicosin 30%

[0021] Microcrystalline Cellulose 40%

[0022] Sodium Carboxymethyl Starch 30%

[0023] Mix the claimed raw materials with appropriate amount of purified water, the solid-liquid ratio is 3:1, put them into a tank mixer and mix for 30 minutes to obtain the pellet core. Composition of coating liquid for tilmicosin pellets:

[0024] Acrylic 50%

[0025] Triethyl Citrate 10%

[0026] Talc 40%

[0027] Add an appropriate amount of water to prepare a coating solution, and the mass ratio of the ball core to the coating material is 2:1;

[0028] Add an appropriate amount of hydroxypropyl methylcellulose into purified water and shear for 15 minutes to prepare a binder with a concentration of 2.5%; put the binder and the ball core into the groove machine and mix evenly, the weight of the binder and the ball core The ratio is 1:2.

[0029] Put the pellet core and binder into the extruder and spheronizer for e...

Embodiment 2

[0031] Composition of tilmicosin pellet core:

[0032] Tilmicosin 55%

[0033] Microcrystalline Cellulose 35%

[0034] Sodium Carboxymethyl Starch 10%

[0035] Mix the claimed raw materials with appropriate amount of purified water, the solid-liquid ratio is 3:1, put them into a tank mixer and mix for 30 minutes to obtain the pellet core. Composition of coating liquid for tilmicosin pellets:

[0036] Acrylic 60%

[0037] Triethyl Citrate 8%

[0038] Talc 32%

[0039] Add an appropriate amount of water to prepare a coating solution, and the mass ratio of the ball core to the coating material is 2:1;

[0040] Add an appropriate amount of povidone into purified water and shear for 15 minutes to prepare a binder with a concentration of 2.5%; put the binder and the ball core into the groove machine and mix evenly, and the weight ratio of the binder to the ball core is 1: 2. Put it into the extruder and spheronizer for extrusion, spheronization, and drying; use 30 mesh and 60...

Embodiment 3

[0042] Composition of tilmicosin pellet core:

[0043] Tilmicosin 60%

[0044] Microcrystalline Cellulose 20%

[0045] Sodium Carboxymethyl Starch 20%

[0046] Mix the claimed raw materials with appropriate amount of purified water, the solid-liquid ratio is 3:1, put them into a tank mixer and mix for 30 minutes to obtain the pellet core. Composition of coating liquid for tilmicosin pellets:

[0047] Acrylic 70%

[0048] Triethyl Citrate 5%

[0049] Talc 25%

[0050] Add an appropriate amount of water to prepare a coating solution, and the mass ratio of the ball core to the coating material is 2:1;

[0051] Add an appropriate amount of starch into purified water and cut for 15 minutes to prepare a binder with a concentration of 2.5%; put the binder into the groove machine and mix it with the ball core. The weight ratio of the binder to the ball core is 1:2. put into the extruder and spheronizer for extrusion, spheronization, and dry; use 30 mesh and 60 mesh sieves for s...

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Abstract

The invention relates to a tilmicosin enteric micro pellet. The tilmicosin enteric micro pellet is composed of tilmicosin, a high molecular carrier, a binder, and a coating liquid. Problems of tilmicosin, such as poor palatability and instability under acidic conditions, are solved, and clinical using amount is increased.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a tilmicosin enteric-coated pellet and a preparation method thereof. Background technique [0002] Tilmicosin (Tilmicosin) is a semi-synthesized antibiotic for livestock and poultry by a hydrolyzate of tylosin, and its molecular formula is C 46 h 80 N 2 o 13 , Molecular weight 869.15, medicinal its phosphate. Tilmicosin is a broad-spectrum antibacterial drug with similar antibacterial activity to other macrolides, and it can inhibit all Gram-positive bacteria and some Gram-negative bacteria, mycoplasma, spirochetes, etc. It has stronger antibacterial activity than tylosin, especially against Actinobacillus pleuropneumoniae, Pasteurella hemolytica, Pasteurella multocida and mycoplasma of livestock and poultry. Oral administration and subcutaneous injection are quickly absorbed, but not completely. The apparent distribution volume is large, the drug concentration in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/706A61K47/38A61K47/32A61P31/04
Inventor 王小武程转红付春香
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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