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Method for preparing asymmetric polymer nanosphere

A technology of polymer and nanospheres, which is used in medical preparations and pharmaceutical formulations with non-active ingredients, can solve the problems of inconvenient post-processing, limited application, insoluble and infusible products, etc., and achieves controllable particle size and operation. Simple and easy process, simple post-processing effect

Active Publication Date: 2015-05-06
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method is always through the traditional method of introducing a cross-linking agent. Although the obtained shape is relatively new compared to the traditional regular balls, the product is insoluble and insoluble, which is not only inconvenient for post-processing, but also limits its later application.

Method used

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  • Method for preparing asymmetric polymer nanosphere
  • Method for preparing asymmetric polymer nanosphere
  • Method for preparing asymmetric polymer nanosphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 0.2mL of the hydrophilic monomer glycidyl methacrylate, 2mL of the hydrophobic monomer styrene, and 0.4mL of saturated hydrocarbon into a three-necked flask containing 30mL of deionized water, stir with nitrogen for 30-60min, and heat up to 75°C , Then add the aqueous solution that is dissolved with 0.04g potassium persulfate initiator. After reacting for 24 hours, a monodisperse styrene-divinylbenzene-glycidyl methacrylate (PS-PGMA) special-shaped polymer nanosphere emulsion was obtained. SEM images of shaped polymer nanospheres figure 1 shown.

Embodiment 2～5

[0025] Embodiment 2~5: with the process condition of embodiment 1, change the amount of saturated hydrocarbon respectively, synthesize the monodisperse styrene-glycidyl methacrylate (PS-PGMA) special-shaped polymer nanosphere emulsion of different shapes, The results are shown in Table 1.

[0026] Table 1

[0027]

Embodiment 4

[0028] The SEM figure of the polymer nanosphere obtained in embodiment 4 is shown in figure 2 , the SEM figure of the polymer nanosphere obtained in embodiment 5 is shown in image 3 .

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Abstract

The invention discloses a method for preparing asymmetric polymer nanospheres, and relates to polymer nanospheres. The method comprises the following steps: adding a hydrophile monomer, a hydrophobic monomer and saturated hydrocarbon into a solvent, introducing nitrogen, heating to implement polymerization reaction, further adding an initiator solution, and continuously introducing nitrogen to react, thereby obtaining the single dispersed asymmetric polymer nanospheres. As the asymmetric polymer nanospheres are prepared by using a soap-free emulsion one-step synthesis method, the method has the advantages that the operation is simple and feasible and the particle sizes of the obtained product, that is, irregular micro spheres, are uniform and controllable. As no emulsifier or stabilizer is added, the obtained product is pure, and polymer photonic crystal which is prepared later can be used without any treatment. The obtained product has the advantages of simple aftertreatment and high pioneering property, and has certain application prospect in medicinal fields such as medicine release and medicine carriers.

Description

technical field [0001] The invention relates to polymer nanospheres, in particular to a preparation method of asymmetric polymer nanospheres. Background technique [0002] In recent years, the application prospects of polymer asymmetric nanospheres in anisotropic photonic crystals, biosensors, and drug delivery vehicles have attracted widespread attention in the scientific community. At present, there are three main methods for the preparation of polymer asymmetric nanospheres, namely: extension of regular spheres, template method and emulsion polymerization. Among them, the extension of regular spheres can only obtain corresponding elliptical spheres, and the application range is limited; the preparation process of template method is complicated and time-consuming, and it is not an effective method for preparing asymmetric nanospheres; emulsion polymerization is not an effective method for preparing polymers. One of the effective methods of symmetric nanospheres can not on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/08C08F220/32C08F2/22A61K47/32
Inventor 戴李宗王爽袁丛辉余世荣符泽浩邵志恒罗伟昂许一婷曾碧榕
Owner XIAMEN UNIV
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