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Pellet type omeprazole enteric capsule and preparation method thereof

A technology of omeprazole intestines and omeprazole pellets, which is applied in the field of medicine, can solve problems such as insufficient release of active ingredients, easy degradation of active ingredients, and large gastrointestinal irritation, so as to achieve improved bioavailability and good curative effect. Existence, enhance the effect of solubility

Inactive Publication Date: 2015-04-29
ZHEJIANG CHANGDIAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing omeprazole enteric-coated capsules have problems such as poor acid resistance, easy degradation of active ingredients, poor stability, great irritation to the stomach, or insufficient and timely release of active ingredients, and low utilization rate.

Method used

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  • Pellet type omeprazole enteric capsule and preparation method thereof
  • Pellet type omeprazole enteric capsule and preparation method thereof
  • Pellet type omeprazole enteric capsule and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] A micropill type omeprazole enteric-coated capsule is a slow-controlled release preparation, the micropill type omeprazole enteric-coated capsule consists of a capsule shell and uniformly mixed omeprazole microparticles contained in the capsule shell. Composition of pills, omeprazole pellets from inside to outside are blank ball core, main drug layer, isolation layer, enteric-coated layer successively, main drug layer weight is 15% of blank ball core, and isolation layer weight is blank ball core and 10% of the total weight of the main drug layer, and the weight of the enteric layer is 28% of the total weight of the blank core, the main drug layer and the isolation layer, wherein 40% of the omeprazole pellets are also coated with a pigment layer outside the enteric layer , the weight of the pigment layer is 0.5% of the total weight of the blank ball core, the main drug layer, the isolation layer and the enteric layer, the diameter of the blank ball core is 1.0 mm, and th...

Embodiment 2

[0040] A micropill type omeprazole enteric-coated capsule is a slow-controlled release preparation, the micropill type omeprazole enteric-coated capsule consists of a capsule shell and uniformly mixed omeprazole microparticles contained in the capsule shell. Composition of pills, omeprazole pellets from inside to outside are blank ball core, main drug layer, isolation layer, enteric coating layer, the weight of main drug layer is 25% of blank ball core, and the weight of isolation layer is blank ball core and 10% of the total weight of the main drug layer, and the weight of the enteric layer is 29% of the total weight of the blank core, the main drug layer and the isolation layer, wherein 45% of the omeprazole pellets are also coated with a pigment layer outside the enteric layer , the weight of the pigment layer is 0.7% of the total weight of the blank ball core, the main drug layer, the isolation layer and the enteric layer, the diameter of the blank ball core is 0.8 mm, and ...

Embodiment 3

[0052] A micropill type omeprazole enteric-coated capsule is a slow-controlled release preparation, the micropill type omeprazole enteric-coated capsule consists of a capsule shell and uniformly mixed omeprazole microparticles contained in the capsule shell. Composition of pills, the omeprazole pellets from inside to outside are blank pellet core, main drug layer, isolation layer, enteric coating layer, the weight of the main drug layer is 40% of the blank pellet core, and the weight of the isolation layer is the blank pill core. 10% of the total weight of the core and the main drug layer, the weight of the enteric layer is 30% of the total weight of the blank core, the main drug layer and the isolation layer, and 50% of the omeprazole pellets are also coated outside the enteric layer Pigment layer, the weight of the pigment layer is 0.8% of the total weight of the blank ball core, the main drug layer, the isolation layer and the enteric coating layer, the diameter of the blank...

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Abstract

The invention discloses a pellet type omeprazole enteric capsule and a preparation method thereof. The pellet type omeprazole enteric capsule is a sustained-release preparation, and is composed of a capsule shell and evenly mixed omeprazole pellets received in the capsule shell; each omeprazole pellet is composed of a blank pill core, a main drug layer, an isolation layer and an enteric layer in order from inside to outside, wherein the weight of the main drug layer accounts for 15-60% of that of the blank pill core, the weight of the isolation layer accounts for 10% of the total weight of the blank pill core and the main drug layer, the weight of the enteric layer accounts for 28-32% of the total weight of the blank pill core, the main drug layer and the isolation layer; besides, the enteric layers of 40-60% of omeprazole pellets are further coated with pigment layers; the weight of the pigment layer accounts for 0.5-1% of the total weight of the blank pill core, the main drug layer, the isolation layer and the enteric layer; the diameters of the blank pill cores are 0.8-1.0mm; the granularity of the omeprazole pellets is 14-20 meshes; each capsule contains 15-30mg of omeprazole. The pellet type omeprazole enteric capsule has the advantages of good acid resistance, sufficient active ingredient release without delay, good stability and the like.

Description

technical field [0001] The invention relates to an omeprazole enteric-coated capsule and a preparation method thereof, in particular to a pellet-shaped omeprazole enteric-coated capsule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Omeprazole, its chemical name is: 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)-methyl]-sulfinyl]- 1H-benzimidazole, molecular formula: C 17 h 19 N 3 o 3 S, molecular weight: 345.42. [0003] Omeprazole is a proton pump inhibitor that can effectively inhibit the secretion of gastric acid. It also has an inhibitory effect on pepsin secretion, does not significantly change gastric mucosal blood flow, and does not affect body temperature, gastric cavity temperature, arterial blood pressure, venous hemoglobin, arterial oxygen partial pressure, carbon dioxide partial pressure, and arterial blood pH. It is also effective for gastric and duodenal ulcers, reflux or erosive esophagiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/4439A61K9/48A61P1/04A61J3/00
Inventor 陈宇东厉达中廖衍孙国庆
Owner ZHEJIANG CHANGDIAN PHARMA
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