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Chitosan microsphere preparation method

A technology of chitosan microspheres and chitosan, which is applied in the direction of microsphere preparation, microcapsule preparation, chemical instruments and methods, etc., can solve problems such as easy adhesion of microsphere products, and achieve simple post-processing procedures and high particle size The effect of non-sticking and low equipment requirements

Inactive Publication Date: 2015-04-22
张家港保税区鑫和成国际贸易有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the microspheres prepared by this method are prone to adhesion

Method used

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Embodiment 1

[0023] A preparation method of chitosan microspheres, comprising the following steps:

[0024] 1) Chitosan solution preparation: Chitosan (Mw=100000g·mol -1 ) was dissolved in formic acid aqueous solution (deionized water and formic acid volume ratio is 90 / 10), the preparation mass fraction is 2wt% chitosan solution, stirred at room temperature until fully dissolved, standing to remove air bubbles, to obtain uniform and transparent chitosan sugar solution;

[0025] 2) Preparation of emulsified cross-linking agent: Stir 20 mL of a mixture of liquid paraffin and petroleum ether with a volume ratio of 7 / 5 evenly, add 1 g of Tween-80 and 3 mL of glutaraldehyde in turn, and stir evenly to obtain emulsified cross-linked agent;

[0026] 3) Preparation of chitosan microspheres: at room temperature, the polymer solution in step 1) was placed in a 5mL syringe, and the extrusion rate was controlled by a micro-injection pump to be 0.1mL / h; the electrospray voltage was 8kV, The distance...

Embodiment 2

[0029] A preparation method of chitosan microspheres, comprising the following steps:

[0030] 1) Chitosan solution preparation: chitosan (Mw=200000g·mol -1 ) was dissolved in formic acid aqueous solution (deionized water and formic acid volume ratio is 50 / 50), the preparation mass fraction is 1wt% chitosan solution, stirred at room temperature until fully dissolved, standing to remove air bubbles, to obtain uniform and transparent chitosan sugar solution;

[0031] 2) Preparation of emulsified cross-linking agent: Stir 50 mL of a mixture of liquid paraffin and petroleum ether with a volume ratio of 7 / 5 evenly, add 2 g of Tween-80 and 0.5 mL of glutaraldehyde in turn, and stir evenly to obtain emulsified cross-linking agent. joint agent;

[0032] 3) Preparation of chitosan microspheres: at room temperature, the polymer solution in step 1) was placed in a 5mL syringe, and the extrusion rate was controlled by a micro-injection pump to be 1.0mL / h; the electrospray voltage was 15...

Embodiment 3

[0034] A preparation method of chitosan microspheres, comprising the following steps:

[0035] 1) Chitosan solution preparation: chitosan (Mw=120000g·mol -1 ) was dissolved in acetic acid aqueous solution (deionized water and acetic acid volume ratio are 90 / 10), the preparation mass fraction is 1.5wt% chitosan solution, stirred at room temperature until fully dissolved, standing to remove air bubbles, to obtain a uniform transparent shell polysaccharide solution;

[0036] 2) Preparation of emulsified cross-linking agent: Stir 30 mL of a mixture of liquid paraffin and petroleum ether with a volume ratio of 7 / 5 evenly, add 1 g of Tween-80 and 1 mL of glutaraldehyde in turn, and stir evenly to obtain emulsified cross-linked agent;

[0037] 3) Preparation of chitosan microspheres: at room temperature, the polymer solution in step 1) was placed in a 5mL syringe, and the extrusion rate was controlled by a micro-injection pump to be 0.5mL / h; the electrospray voltage was 10kV, The ...

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Abstract

The invention belongs to the field of polymer materials, and relates to a chitosan microsphere preparation method, firstly, chitosan solutions with different volatile properties are prepared by adjustment of the ratio of solvents, the chitosan solutions are s dispersed into tiny droplets by use of electrostatic spray method by electrostatic force; secondly, the tiny droplets are formed into microsphere morphology in the air through the process of solvent evaporation, shrinkage and the like, and finally are received by an emulsion crosslinking agent prepared from liquid paraffin, petroleum ether, Twain-80 and glutaraldehyde. After the electrostatic spray, chitosan microspheres are obtained by centrifugal separation, washing with ethanol and other steps. According to the method, the chitosan microspheres are obtained from a natural polymer material by electrostatic spray emulsification crosslinking method, the method is low in requirement to equipment, a collecting device and post-processing process are simple, cost is low, the emulsification and cross-linking agent can be used repeatedly, and the obtained chitosan microspheres are small in particle size and non-sticky.

Description

technical field [0001] The invention belongs to the field of polymer materials and relates to a preparation method of chitosan microspheres. Background technique [0002] The chemical name of chitosan (Chitosan) is poly(1,4)-2-amino-2-deoxy-β-D glucan, which is one of the most abundant natural polymers on earth and has good biocompatibility Sexuality, biodegradability and non-toxicity of degradation products. Chitosan is one of the few charged natural products with many unique physical and chemical properties and biological functions. Chitosan microspheres play a key role in the fields of medicine, sterilization, and micro-separators. Chitosan microspheres with different particle sizes and shapes are responsible for different functions such as drug loading, sterilization, and adsorption and separation. At present, the common preparation methods of chitosan microspheres include chemical cross-linking method, ion exchange method, complex coacervation method, spray drying met...

Claims

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Application Information

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IPC IPC(8): B01J13/14B01J20/24A61K47/36
CPCA61K47/36B01J13/14B01J20/24B01J2220/4825
Inventor 范佳晨
Owner 张家港保税区鑫和成国际贸易有限公司
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