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Oral medicine composition for resisting radiation, preventing dental caries and diminishing inflammation and preparation thereof

An anti-radiation and composition technology, which is applied in the directions of drug combinations, active ingredients of fluorine compounds, and medical preparations containing active ingredients, etc. The effect of anti-inflammatory and anti-radiation immunity, blocking lipid peroxidation process, and improving the activity of enzymes

Inactive Publication Date: 2015-04-08
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current medicines for radiation-induced oral diseases are generally symptomatic treatment, with poor curative effect, certain toxic and side effects, lack of pertinence and portability, and are not suitable for preventive treatment under emergency conditions

Method used

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  • Oral medicine composition for resisting radiation, preventing dental caries and diminishing inflammation and preparation thereof
  • Oral medicine composition for resisting radiation, preventing dental caries and diminishing inflammation and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Anti-radiation anti-caries anti-inflammatory mouthwash, in parts by mass, includes 100 parts of white lentil extract, 100 parts of grape seed proanthocyanidin extract, 300 parts of tea polyphenols, 0.05 parts of epidermal growth factor EGF, 20 parts of Yujiechun, 2 parts of ammonium hexafluorosilicate, 10 parts of pilocarpine with a mass fraction of 2%, 100 parts of lidocaine, 100 parts of menthol, 100 parts of sorbitol, 100 parts of sweetener, 100 parts Food essence and 9130 parts of distilled water.

[0038] The preparation method of the anti-radiation anti-caries and anti-inflammatory mouthwash is as follows: in the aseptic production workshop, white lentil extract, grape seed proanthocyanidin extract, tea polyphenols, epidermal growth factor EGF, Yujiechun, ammonium hexafluorosilicate, Add 0.2% pilocarpine, sorbitol and lidocaine into a clean glass container in sequence according to the above proportions, stir gently, and mix well, then add menthol, sweetener, sorbi...

Embodiment 2

[0041] The anti-radiation, anti-caries, anti-inflammatory and fast-breaking mouthwash tablets, in parts by mass, include 300 parts of white lentil extract, 500 parts of grape seed proanthocyanidin extract, 500 parts of tea polyphenols, 0.05 parts of epidermal growth factor EGF, 100 parts of Yujiechun, 2 parts of ammonium hexafluorosilicate, 500 parts of soluble starch, 5750 parts of mannitol, 900 parts of povidone K30, 1500 parts of microcrystalline cellulose, 500 parts of cross-linked Povidone XL-10, 50 parts of dipeptide sweetener, 200 parts of menthol, 10 parts of food flavor.

[0042] The preparation method of the anti-radiation, anti-caries, anti-inflammatory and rapid collapse mouthwash tablet is as follows: according to the above prescriptions, the white lentil extract, grape seed proanthocyanidin extract, tea polyphenol, epidermal growth factor EGF, Yujiechun, ammonium hexafluorosilicate 1. Add mannitol into a clean glass container, stir gently, and mix well, then add ...

Embodiment 3

[0045] Anti-radiation, anti-caries and anti-inflammatory effervescent tablets, in parts by mass, include 300 parts of white lentil extract, 1000 parts of grape seed proanthocyanidin extract, 1000 parts of tea polyphenols, 0.05 parts of epidermal growth factor EGF, 100 parts Yujiechun, 2 parts of ammonium hexafluorosilicate, 500 parts of soluble starch, 4200 parts of sodium bicarbonate, 2800 parts of citric acid, 10 parts of dipeptide sweetener, 14 parts of hydroxypropyl cellulose , 10 parts of polyethylene glycol 6000, 100 parts of menthol and 10 parts of food flavor.

[0046] The preparation method of the anti-radiation anti-caries anti-inflammatory effervescent tablet is as follows: uniformly mix the dipeptide sweetener and sodium bicarbonate, pass through a 16-mesh sieve, and dry at 50°C; separately take hydroxypropyl cellulose and add ethanol to moisten and disperse, Add an appropriate amount of distilled water to make it swell into a slurry; take a portion of citric acid,...

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Abstract

The invention discloses an oral medicine composition for resisting radiation, preventing dental caries and diminishing inflammation and a preparation thereof, and belongs to the technical field of oral medicine preparations. The composition is prepared from the following components in parts by mass: 100-500 parts of white hyacinth bean extract, 100-2000 parts of grape seed proanthocyanidin extract, 300-3000 parts of tea polyphenol, 0.01-0.1 part of epidermal growth factor EGF, 10-200 parts of triclosan and 2-6 parts of ammonium hexafluorosilicate. The oral medicine composition and the preparation thereof disclosed by the invention have a durable antibacterial effect, can be attached to the surface of teeth or oral cavity for a long time to form a protective film, can be used for tenderly protecting the oral cavity, has an excellent taste, and is safe to human bodies.

Description

technical field [0001] The invention belongs to the technical field of oral pharmaceutical preparations, and in particular relates to an oral pharmaceutical composition for anti-radiation, anti-caries and anti-inflammation and its preparation. Background technique [0002] After the human body is exposed to a certain dose of ionizing radiation, not only the early acute effects can appear at the time of exposure, but also the long-term effects appear after several years or even longer after exposure. The effect of ionizing radiation on water molecules and biomolecules such as proteins in human cells is of special significance. The ionization and excitation of water molecules produce free radicals, and free radicals are the main cause of radiation damage to organic molecules. reason. In addition, ionizing radiation can cause changes in cell division delay and cell death. The biological effects produced by radiation include direct action and indirect action. Direct action is...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P1/02A61K36/87A61K31/353A61K33/16
Inventor 李广文李刚李卉王军
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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