Application of atractylenolide-II derivative in preparation of platelet aggregation resisting drug and platelet aggregation resisting drug

Abstract

The invention relates to a platelet aggregation resisting drug. The platelet aggregation resisting drug comprises an atractylenolide-II derivative represented by a structural formula 1 shown in specifications. The invention further relates to application of an atractylenolide-II derivative in preparation of the platelet aggregation resisting drug. The platelet aggregation resisting drug, which is simple in composition and is prepared from effective ingredients of natural medicinal raw materials or effective ingredient extracts of the medicinal raw materials, provided by the invention has a good treatment effect, is free from toxic or side effects, is not prone to the generation of tolerance, is convenient to take and is generally applicable to the problems, such as viscous blood and thrombus, caused by too-high platelet aggregation rate.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the preparation and application of atractyloid II derivatives for anti-platelet aggregation. Background technique [0002] Modern medicine believes that there is a certain relationship between the formation of thrombus and the high rate of platelet aggregation. [0003] Thrombus starts from the local coagulation mechanism. After thrombus formation on the surface of hyperarterial intima, the thrombus is covered by proliferating endothelial cells, and the platelets and white blood cells incorporated into the arterial wall thrombus disintegrate to release lipids and other active substances, gradually forming Atheromatous plaque. The latter believes that the disease begins with arterial intima injury, platelet activating factor (PAF) increases, platelets adhere and then aggregate there, followed by fibrin deposition to form microthrombi. After platelets aggregate, some active substances are...

AI Technical Summary

Problems solved by technology

But sometimes thrombosis may have no obvious symptoms, such as the common deep vein thrombosis of the lower extremities, only calf soreness and discomfort, many patients think it is fatigue or catch a cold, do not take it seriously, so it is easy to miss the best time for treatment

It is particularly regrettable that many doctors are prone to misdiagnose this, and when typical lower extremity edema occurs, it will not only bring difficulties to the treatment, but also easily leave sequelae

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