Yupingfeng powder active ingredient composition and preparation method and application thereof

An active ingredient, Yupingfeng Powder technology, applied in the field of Yupingfeng Powder active ingredient composition and its preparation, can solve the problems of limited competitiveness, complex compound ingredients, etc., to achieve the effect of modernization and internationalization

Inactive Publication Date: 2015-04-01
NANJING UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] Although China has the advantages of rich traditional Chinese medicine resources, its compound ingredients are extremely complex, which limits its international competitiveness. To change the status quo, it is necessary to take the road of modernization

Method used

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  • Yupingfeng powder active ingredient composition and preparation method and application thereof
  • Yupingfeng powder active ingredient composition and preparation method and application thereof

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Embodiment Construction

[0037] 1. Experimental method

[0038] BALB / c mice (normal group)

[0039] BALB / c pure line mice (purchased from Model Animal Center of Nanjing University), clean grade, weighing 18-22 g, half male and half male. Adaptive feeding. From the first day to the fifth day of the experiment, 0.2 ml of normal saline (0.9% NaCl) was administered to the stomach twice, with an interval of 6 hours between each time.

[0040] Construction of 2,4-Dinitrochlorobenzene-sensitized mouse model (DTH mice, pathological group / model group)

[0041] BALB / c pure line mice (purchased from Model Animal Center of Nanjing University), clean grade, weighing 18-22 g, half male and half male. Adaptive feeding for several days. The day before the experiment, the hair on the abdomen of the mouse was shaved, and 20ul of 1% 2,4-dinitrofluorobenzene (DNFB) (acetone: olive oil = 4:1) was applied for sensitization on the first morning. From the first day to the fifth day of the experiment, 0.2 ml of normal sa...

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Abstract

The invention belongs to the technical field of preparation of traditional Chinese medicines. The invention specifically relates to a Yupingfeng powder active ingredient composition and a preparation method and application thereof. The Yupingfeng powder active ingredient composition is produced by combining astragaloside, atractylenolide I and prim-o-glucosylcimifugin according to different proportions. According to the Yupingfeng powder active ingredient composition provided by the invention, traditional Chinese medicines are combined with the modern science and technology, the western medicine standard is used for research and development of the traditional Chinese medicine, the medicinal effects and the chemical components are presented in a standardized manner, and the modern traditional Chinese medicine with safety, stability and controllable quality is further researched and developed. The composition has three major factors, namely safety, effectiveness and controllable quality of the medicine. The composition is favorable for solving the problem of enabling the traditional Chinese medicine to be in line with the development trend of international medicines, and is favorable for realizing modernization and internationalization of the traditional Chinese medicine. The composition inherits and develops the traditional Chinese medicine, combines with the modern medicine technology, and is a key for enabling the traditional Chinese medicine to enter the international market.

Description

1. Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation. Specifically, it relates to a composition of active ingredients of Yupingfeng powder, a preparation method and application thereof. 2. Background technology [0002] A normal immune response is the main mechanism for the body to maintain its own balance and resist foreign aggression. Excessive immune responses can cause various autoimmune diseases, allergies, and various inflammatory reactions. Existing immunosuppressants aimed at suppressing excess immune response, such as glucocorticoids, cyclophosphamide, etc., often lead to overall suppression of immune response due to their lack of selectivity to cells and tissues, resulting in serious side effects. Cyclosporin A is found in the metabolites of Cyclospora fungus, and forms a complex by binding to cycloavidin, thereby inhibiting the function of calmodulin phosphatase and further inhibiting the genes activat...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P11/00A61P31/00A61P11/06A61P11/02A61P17/04A61P17/00A61P37/08A61P19/02A61P13/12A61P37/02A61P35/00A61P29/00A61P1/16A61K31/365
Inventor 杨洁
Owner NANJING UNIV
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