Preparation method of methanamide

Abstract

The invention relates to a preparation method of methanamide. The method uses formamide or its derivative and amine (primary or secondary amine) as reactants, which are subjected to amidomethylation in the presence of a catalyst to prepare methanamide. The method is characterized in that solid acidic metal oxide or precious metal loaded acidic metal oxide is used as the catalyst and the reaction is carried out efficiently under mild conditions. The reaction process is as follows: mixing formamide with certain concentration or its derivatives with primary or secondary amine and a certain amount of catalyst, placing the mixture into pressure vessel without adding or additionally adding other solvent, sealing, stirring at a temperature no less than 60 DEG C, and reacting for no less than 0.5 h to obtain the reaction product methanamide. The method has the advantages of simple preparation of the catalyst, easy separation process of the catalyst and product, repeated usage of the catalyst, high controllability of the reaction process, and yield of the product formamide reaching more than 95%.

Description

technical field [0001] The invention relates to a method for preparing formamide, in particular to catalyzing the formamide reaction of formamide or its derivatives with amines (primary or secondary amines) to prepare formamide as a product. Background technique [0002] The amide group is a very important chemical group that exists in many natural polymers, such as: polypeptides, proteins, etc. In addition, amides are also excellent synthetic monomers, which can be used to prepare polymers such as nylon. CN101970675A discloses a method for preparing amide compounds by biocatalyzing nitrile compounds. A patent (CN102712576A) of BASF Europe uses phosphoric acid or Lewis acidic metal salts as catalysts to catalyze the conversion of aromatic amines and formates to prepare aromatic formamides. Patent CN101684076B uses amino acid ionic liquid as reaction medium and catalyst to catalyze the Beckmann rearrangement reaction of ketoxime to prepare amides. [0003] Although there a...

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Problems solved by technology

[0003] Although there are many studies on the preparation methods of amides, there are some disadvantages: for example, the catalyst preparation process is complicated, the reaction time is long, the reaction yield is low, the environment is polluted, and the catalyst is easily deactivated after the reaction.

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