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Drug sustained-release microsphere capable of being embedded in intraocular lens loop and preparation method of drug sustained-release microsphere

A technology of intraocular lens and sustained-release microspheres, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve the problem that the sustained release time and concentration of drugs cannot meet the clinical application requirements, and the inhibitory effect and degree of inhibition are not enough. Determine the toxicity and side effects of other tissues in the eye, achieve the effect of simple and effective drug loading and release speed, reduce intraocular inflammation and infection, improve visual quality and long-term vision

Inactive Publication Date: 2015-03-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are still the following disadvantages: 1) the scope of influence is limited to the surface of the intraocular lens or nearby areas, and the antibacterial ability is limited; 2) the inhibitory effect and degree of inhibition of endophthalmitis by hydrophilicity or free radicals are uncertain and adjustable not tall
3) The sustained release time and concentration of the drug cannot meet the requirements of clinical application
Although the above method can inhibit the proliferation of residual lens epithelial cells through in situ antibody inhibition or local concentration of drugs, it can only play a role through contact antibody inhibition, and the range of inhibition is small; or the formed drug coating Poor stability, high possibility of drug release, which may have toxic side effects on other tissues in the eye

Method used

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  • Drug sustained-release microsphere capable of being embedded in intraocular lens loop and preparation method of drug sustained-release microsphere
  • Drug sustained-release microsphere capable of being embedded in intraocular lens loop and preparation method of drug sustained-release microsphere
  • Drug sustained-release microsphere capable of being embedded in intraocular lens loop and preparation method of drug sustained-release microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The manufacture method of drug sustained-release microspheres comprises the following steps:

[0040] 1) Put 500mg of gatifloxacin powder and 1500mg of glyceryl tristearate powder in a glass beaker, heat and stir the beaker in a water bath at 80°C until the solid melts; extract 5ml of the above liquid with a syringe and add 1ml / The speed of sec is quickly injected into the nozzle heated to 80°C (the diameter of the nozzle is 1500 microns); at the same time, the 6.8kpa air output from the air compressor passes through the heating nozzle and then sprays out from the nozzle of the nozzle together with the aforementioned liquid (spraying Height of about 1.0m), the above-mentioned liquid is sprayed and condensed into microspheres of 400-800 microns in the air; sterilized by ethylene oxide and packaged in a sealed manner.

example 2

[0042] 1) Put 300mg of fleroxacin powder and 700mg of stearic acid powder in a glass beaker, heat and stir the beaker in a water bath at 75°C until the solid melts; draw 3ml of the above liquid with a syringe and rapidly dissolve it at a rate of 0.5ml / sec Inject into the nozzle heated to 75°C (the diameter of the nozzle is 1000 microns); at the same time, the 7.1kpa air output from the air compressor passes through the heated nozzle and then sprays out from the nozzle of the nozzle together with the aforementioned liquid (the spray height is about 1.5m) ), the above-mentioned liquid is sprayed and condensed into microspheres of 600 microns in the air; sterilized by ethylene oxide, sealed and packaged.

example 3

[0044] 1) Put 400mg of clarithromycin powder, 200mg of oleic acid and 400mg of monoglyceride powder into a glass beaker, heat and stir the beaker in a 70°C water bath until the solid melts; draw 2ml of the above liquid with a syringe and add 1.5ml The speed of / sec is quickly injected into the nozzle heated to 70°C (the diameter of the nozzle is 600 microns); at the same time, the 5.5kpa air output from the air compressor passes through the heated nozzle, and then sprays out from the nozzle of the nozzle together with the aforementioned liquid In a confined space (spraying height of about 2.0m), the above liquid is sprayed and condensed into 200 micron microspheres in the air; sterilized by ethylene oxide and sealed in a package.

[0045] The heating of shower head in above-mentioned 3 embodiments can adopt electric heater or far-infrared heater or alcohol lamp.

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Abstract

The invention relates to a drug sustained-release microsphere capable of being embedded in intraocular lens loop and a preparation method of the drug sustained-release microsphere. The drug sustained-release microsphere prepared by the provided method can be used for effectively preventing and treating microorganism infection and antagonistic inflammatory reaction after a cataract surgery, reducing the occurrence rate of intraocular inflammation infection after the cataract surgery, and preventing and inhibiting after-cataract, so as to improve visual quality after the surgery. The technical scheme is that according to the drug sustained-release microsphere capable of being embedded in the intraocular lens loop, the drug sustained-release microsphere is formed by mixing drugs and a carrier at the ratio of 1 to (10000-1), and the drug sustained-release microsphere is 100-800mm in diameter. The preparation method of the drug sustained-release microsphere capable of being embedded in the intraocular lens loop sequentially comprises the following steps: (1) mixing the drugs and the carrier according to the ratio and stirring to obtain mixed liquid; (2) condensing fog-like materials in a collecting room to obtain microspheres; and (3) collecting the microspheres and screening the microspheres by virtue of a screen to obtain the microspheres with required diameters; disinfecting, sealing and packaging the microspheres.

Description

technical field [0001] The invention relates to a drug slow-release microsphere that can be embedded in a foldable intraocular lens loop in femtosecond laser cataract surgery and phacoemulsification cataract extraction and a preparation method thereof, which is used for inhibiting microbial infection after cataract surgery and antagonizing inflammatory reactions, Prevention and inhibition of post cataract. Background technique [0002] Cataract is the leading cause of blindness in the world; surgical removal of cataract and implantation of intraocular lens is currently the only effective way to treat cataract. Cataract surgery is quite mature, but there are still potential postoperative complications that may lead to postoperative vision loss or even blindness, such as infectious endophthalmitis and post-cataract after cataract surgery. Infectious endophthalmitis refers to the destructive inflammatory reaction of the retina, choroid and vitreous body caused by microorganism...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K45/00A61K47/14A61K47/12A61P31/04A61P29/00A61P27/12
Inventor 姚克丁文婷
Owner ZHEJIANG UNIV
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