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Mouth rinse emulsions

A technology for mouthwash and oral care, applied in oral care, antibacterial drugs, drug combinations, etc., can solve the impact of bioavailability of active ingredients, reduce bioavailability, reduce bioavailability of cationic antimicrobial agent chlorhexidine, etc. question

Inactive Publication Date: 2015-03-11
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, surfactants may have an adverse effect on the bioavailability of some active ingredients
For example, surfactants may reduce the bioavailability of cationic antimicrobials such as cetylpyridinium chloride due to the formation of mixed micelles in aqueous vehicles. (CPC) and bioavailability of chlorhexidine
In addition, the bioavailability of CPC may be reduced by the flavor oil itself or by the addition of electrolytes or other water-soluble components such as fluoride and saccharin

Method used

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  • Mouth rinse emulsions
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Examples

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example

[0172] The following examples further describe and demonstrate embodiments within the scope of the present invention. These examples are given for illustrative purposes only and are not to be construed as limitations of the invention.

example 1

[0173] Example 1: Mouthwash composition

[0174] Mouthwash emulsion compositions A - F according to the invention are shown below, wherein the amounts of the components are in % by weight.

[0175] components

example 2

[0176] Example 2: In Vitro Biofilm Reduction

[0177] The efficacy of mouthwash emulsions of the present invention with high flavor oil loading was compared to conventional clear mouthwashes using the in vitro particle-based biofilm (PBB) model described below. The samples tested are shown in Table 1 below, and the test results are shown in Tables 2 and 3.

[0178] Table 1

[0179]

[0180] Human saliva was collected daily from five to seven donors for PBB culture. Saliva donors need to meet minimum selection criteria, including but not limited to:

[0181] · Between 18 and 50 years old

[0182] Have not had prophylaxis nor experienced any treatment for oral or dental disease in the past 4 weeks

[0183] Has not used any type of mouthwash, dental floss or toothpicks within the past 48 hours or during the collection phase

[0184] Has not used any type of antibacterial toothpaste within the past 48 hours or during the collection phase

[0185] · Absence of fever (>...

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Abstract

Disclosed are oral care mouth rinse compositions formulated as stable oil-in-water emulsions comprising: (a) at least about 0.025% by weight of a quaternary ammonium antimicrobial agent, (b) at least about 0.05% by weight of an essentially water-insoluble volatile oil, and (c) at least about 50% by weight water, wherein the emulsion comprises oil droplets having an average mean particle size of about 350 nm or less. Examples of quaternary ammonium antimicrobial agent include cetylpyridinium chloride (CPC), tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide.

Description

technical field [0001] The present invention relates to mouthwash compositions formulated as oil-in-water emulsions comprising one or more oral care actives and flavor oils. Background technique [0002] Consumers routinely use oral care products such as mouthwashes as part of their oral care hygiene regimen to provide therapeutic, hygiene and cosmetic benefits. Therapeutic benefits include: caries prevention, typically delivered through the use of various fluoride salts; prevention of gingivitis and periodontal disease through the use of antimicrobial agents such as triclosan, stannous fluoride, quaternary ammonium compounds, or essential oils; or Fight allergies by using ingredients like strontium chloride, stannous fluoride, or potassium nitrate. Hygiene and cosmetic benefits include: prevention of plaque and calculus formation, removal and prevention of dental stains, tooth whitening, fresh breath, and general improvement in mouthfeel impression (which can be broadly ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/41A61K8/92A61K8/06C12Q1/18A61Q11/00
CPCA61K8/062A61Q17/005A61Q11/00A61K8/416C12Q1/18A61P1/02A61P31/04A61K8/92
Inventor D·C·斯科特N·拉姆吉B·E·泰珀
Owner THE PROCTER & GAMBLE COMPANY
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