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External use medicine composition and preparing method thereof

A technology for external use of medicines and compositions, applied in the field of medicine synthesis, can solve the problems of differences in treatment effects, increase facial hair, reduce libido, etc., and achieve the effects of smooth appearance, easy coating and use, and suitable viscosity

Inactive Publication Date: 2015-02-11
HYBIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of drugs to treat hair loss not only varies in the treatment effect, but also causes various risks and side effects such as scalp laceration, increased facial hair, and decreased libido

Method used

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  • External use medicine composition and preparing method thereof
  • External use medicine composition and preparing method thereof
  • External use medicine composition and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: Preparation of low-dose pharmaceutical composition for external use

[0051] 1. Prescription

[0052]

[0053] 2. Preparation

[0054]Sprinkle Carbomer 940 in water and let it swell. Dissolve glycerin, propylene glycol, potassium sorbate, and salicylic acid in water and mix well. Add it to the above carbomer solution and mix evenly, adjust the pH to 6.0 with triethanolamine, and stir evenly to obtain a colorless transparent gel. The astressin-B is added to the above gel, stirred and mixed to obtain a low-dose pharmaceutical composition for external use.

Embodiment 2

[0055] Embodiment 2: the preparation of middle-dose pharmaceutical composition for external use

[0056] 1. Prescription

[0057]

[0058] 2. Preparation

[0059] Sprinkle Carbomer 940 in water and let it swell. Dissolve glycerin, propylene glycol, potassium sorbate, and urea in water, and mix well. Add it to the above carbomer solution and mix evenly, adjust the pH to 6.0 with triethanolamine, and stir evenly to obtain a colorless transparent gel. Dissolve menthol with 95% ethanol, add to the gel, and stir to mix. The astressin-B is added to the above gel, stirred and mixed evenly, and a medium-dose external pharmaceutical composition can be obtained.

Embodiment 3

[0060] Embodiment 3: Preparation of high-dose pharmaceutical composition for external use

[0061] 1. Prescription

[0062]

[0063] 2. Preparation

[0064] Spread hydroxyethyl cellulose in water and let it swell until it swells to obtain a colorless transparent gel. Add acetate buffer to control the pH of the gel at 5.5. Add glycerin, propylene glycol, sodium benzoate and water-soluble azone into the above gel, and stir evenly. The astressin-B is added to the above-mentioned gel and stirred evenly to obtain a high-dose pharmaceutical composition for external use.

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PUM

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Abstract

The invention belongs to the technical field of medicine compositions, and discloses an external use medicine composition used for treating alopecia. The external use medicine composition comprises annular adrenocorticotrophic hormone release factor (CRF) antagonism peptide astressin B in effective treatment amount or acceptable salt on the pharmacy. The external use medicine composition is in a gel dosage form preferably and suitable for clinic use and industrialization production. In addition, the invention further discloses a method for preparing the external use medicine composition and application of the astressin B in effective treatment amount or the acceptable salt on the pharmacy to preparing the external use medicine composition used for treating the alopecia. According to the external use medicine composition, the problem of the alopecia for a long time can be effectively treated; and the external use medicine composition is safe, reliable, free of obvious skin irritants and free of sensitization.

Description

technical field [0001] The invention relates to the technical field of drug synthesis, in particular to an external pharmaceutical composition, which contains a cyclic corticotropin releasing factor (CRF) antagonistic peptide astressin B or a pharmaceutically acceptable salt thereof. Background technique [0002] Hair loss is a concern for a large number of men and women. Although hair loss is more common in men (for example, male pattern alopecia or androgenetic alopecia), hair loss can also be present in some women (female pattern alopecia). For many men and women, hair loss can cause embarrassment, and / or psychological problems (such as depression, etc.). In fact, many countries around the world have been working on this problem. [0003] The mature hair follicle is a complex miniature organ with a tightly regulated growth cycle. [0004] People lose 50-100 hairs every day. This is because the growth of hair is cyclical, which can be divided into growth period, regress...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61P17/14
Inventor 郑春莲刘建马亚平袁建成
Owner HYBIO PHARMA
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