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Glabridin microcapsule and preparation method thereof

A technology of glabridin and microcapsules, which is applied in microcapsules, capsule delivery, and pharmaceutical formulations to achieve good encapsulation effects, good fluidity, and good stability

Inactive Publication Date: 2015-01-28
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no research reports on glabridin microcapsules at home and abroad, especially the preparation of glabridin microcapsules with ethyl cellulose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A glabridin microcapsule particle, which consists of the following components by weight:

[0025] Glabridin 2 parts;

[0026] 1 part ethyl cellulose;

[0027] 0.1 part of polyethylene glycol;

[0028] 1.8 parts of sodium carboxymethyl starch.

[0029]

[0030] Its preparation method is:

[0031] (1) Dissolving 1 part by weight of ethyl cellulose in dichloromethane to prepare an ethyl cellulose solution, the concentration of the ethyl cellulose solution is 5% g / ml;

[0032] (2) Add 2 parts by weight of glabridin, 0.1 parts by weight of polyethylene glycol and 1.8 parts by weight of sodium carboxymethyl starch to the above ethyl cellulose solution, stir to make it fully suspended, and control the stirring speed at 1000 Turn per minute, slowly add petroleum ether dropwise, until the system is completely precipitated, separate the precipitated microcapsules from the solvent to obtain a mixture of capsules and solvent A, and dry the capsules in a dryer to obtain glabrid...

Embodiment 2

[0035] A glabridin microcapsule granule, which consists of the following ingredients in parts by weight:

[0036] Glabridin 3 parts;

[0037] 1 part ethyl cellulose;

[0038] 0.2 parts of polyethylene glycol;

[0039] 0.5 part of sodium carboxymethyl starch.

[0040]

[0041] Its preparation method is:

[0042] (1) Dissolving 1 part by weight of ethyl cellulose in dichloromethane to prepare an ethyl cellulose solution, the concentration of the ethyl cellulose solution is 6% g / ml;

[0043] (2) Add 3 parts by weight of glabridin, 0.2 parts by weight of polyethylene glycol and 0.5 parts by weight of sodium carboxymethyl starch to the above ethyl cellulose solution, stir to make it fully suspended, and control the stirring speed at 1500 Turn per minute, slowly add petroleum ether dropwise, until the system is completely precipitated, separate the precipitated microcapsules from the solvent to obtain a mixture of capsules and solvent A, and dry the capsules in a dryer to obta...

Embodiment 3

[0046] A glabridin microcapsule granule, which consists of the following ingredients in parts by weight:

[0047] Glabridin 2 parts;

[0048] 1.5 parts of ethyl cellulose;

[0049] 0.05 part of polyethylene glycol;

[0050] 1.0 parts of sodium carboxymethyl starch.

[0051]

[0052] Its preparation method is:

[0053] (1) Dissolve 1.5 parts by weight of ethyl cellulose in the fraction of the mixed solvent A separated from the above Example 1 at normal pressure and less than 45°C, and prepare the ethyl cellulose solution with a concentration of 7.0% g / ml ;

[0054] (2) Add 2 parts by weight of glabridin, 0.05 parts by weight of polyethylene glycol and 1.0 part by weight of sodium carboxymethyl starch to the above ethyl cellulose solution, stir to make it fully suspended, and control the stirring speed at 1200 RPM, slowly add dropwise the fraction of the solvent mixture A separated from the above example 1 at normal pressure and greater than 60°C until the system precipit...

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PUM

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Abstract

The invention relates to a glabridin microcapsule including 0.8-3.0 parts of glabridin, 0.8-2.0 parts of ethyl cellulose, 0-0.3 part of polyethylene glycol and 0.2-2.5 parts of sodium carboxymethyl starch. The invention discloses a preparation method. The glabridin microcapsule prepared by the invention has good stability, good encapsulation effect, good fluidity, good dissolution, yield up to above 90% and drug loading higher than 50%; and the microcapsule has a quasi-circular shape and particle size between 60-80 mesh, so as to achieve the purposes of slow release and controlled release.

Description

technical field [0001] The invention relates to glabridin microcapsules and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Glabridin is a flavonoid component in Glycyrrhizae glabra. As a natural antioxidant and free radical scavenger, it has been used in the field of cosmetics. Modern research shows that glabridin has anti-tumor, anti-blood acid, blood lipid-lowering, Anti-oxidation, anti-aging and other biological activities, in the field of medicine, the research and development of glabridin has become a hot spot. At present, the research and development of glabridin is mostly focused on purification and preparation, and the research and development of related preparations is less reported. The process of conventionally preparing oral solid preparations must go through the process of making raw materials and certain auxiliary materials into intermediates, so that the raw materials have fluidity, hydrophobicity and ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/352A61K47/38A61K47/34A61K47/36A61K47/06A61K47/08A61P39/06A61P35/00A61P3/06A61P7/02
Inventor 魏元刚杨永安钟慧季浩
Owner JIANGSU TIANSHENG PHARMA
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