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Medicine water suspended emulsion containing rebamipide and preparation method of medicine water suspended emulsion

A technology of rebamipide and aqueous suspension, applied in the field of drug aqueous suspension containing rebamipide, which can solve the problems of incomplete dissolution of rebamipide and unavoidable precipitation layer, etc.

Inactive Publication Date: 2015-01-14
NANJING HUAWE MEDICINE TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the suspension in WO 2008 / 05089 is a white ophthalmic suspension in which rebamipide is not completely dissolved, and it cannot avoid the formation of a precipitate layer of rebamipide when left standing for a long time

Method used

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  • Medicine water suspended emulsion containing rebamipide and preparation method of medicine water suspended emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Follow-up formulation

[0029] Rebappet

[0030] Production: Add excipients other than rebamipide to water for injection, filter the obtained solution after sterilization, add rebamipide fine particles, and stir to obtain an aqueous suspension.

Embodiment 2

[0031] Example 2: Ophthalmic Formulation

[0032] Rebappet

[0033] Production: Add excipients other than rebamipide to water for injection, filter the obtained solution after sterilization, add rebamipide fine particles, and stir to obtain an aqueous suspension.

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Abstract

The invention provides medicine water suspended emulsion containing rebamipide and povidone, wherein rebamipide fine particles dispersed in the water suspended emulsion can maintain a stable dispersed state and can not get together; besides, the invention also provides a method for preparing the medicine water suspended emulsion containing rebamipide and povidone, and the method for preparing the medicine water suspended emulsion comprises the step of mixing povidone and sodium salt compound with rebamipide.

Description

technical field [0001] The present invention relates to a medicament for treating anterior segment diseases, in particular to a rebamipide-containing medicament aqueous suspension, which can be prepared by a simple method and keeps the dispersed rebamipide fine particles in a stable state. Background technique [0002] The corneal or conjunctival surface of patients with anterior segment disorders, including corneal and conjunctival disorders, such as dry eye, is damaged for a variety of reasons. In particular, various factors in dry eye, such as reduced tear volume or tear evaporation, can cause ocular dryness (ie, "dry eye") and damage to the eye. Therefore, dry eye runs the risk of causing corneal ulcers or vision loss if left untreated. [0003] In recent years, rebamipide has been developed as a new drug based on a new mode of action, Chinese name: 2-(4-chlorobenzamido)-3-(1,2-dihydro-2-oxo-4- Quinolinyl) propionic acid, English name: Rebamipide, the structural formul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/4704A61K47/32A61P27/02
Inventor 胡丹丹丁刚刘平陈微娜蒋玉伟张孝清
Owner NANJING HUAWE MEDICINE TECH DEV
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