Crystallization method of sucralose

A sucralose and crystallization technology, applied in the crystallization field of sucralose, can solve the problems of increasing process steps and production costs, increasing the fluidity of sucralose, and high requirements for reaction devices, achieving broad market application prospects and being conducive to industrialization The effect of low production and production costs

Inactive Publication Date: 2019-05-17
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] US5298611 describes a method of using a granulator to produce sucralose spherical crystals, which effectively increases the fluidity of sucralose and reduces dust, but increases process steps and production costs; CN101260126 describes a method that uses alcohols A method for crystallizing sucralose solids or concentrates with a mixed solvent composed of solvents or alcohols and other solvents, but this method requires a long production time and reduces production efficiency; The method of crystallization with mixed solvents, volatilizes the low-boiling point solvent under appropriate temperature and vacuum conditions, stands and filters, and dries to obtain sucralose crystals, but because the process requires vacuum conditions, the requirements for the reaction device are relatively high

Method used

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  • Crystallization method of sucralose
  • Crystallization method of sucralose
  • Crystallization method of sucralose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add 40 mL of methyl acetate to 20 mL (24 g) of the crude sucralose solution, mix and stir for 4 h at room temperature, filter to remove impurities; add 20 mL of water-methanol mixed solution with a molar ratio of 3:7, heat up to 60°C, and stir to react 6 Hours later, the temperature was lowered to 20 ºC at a rate of 5 ºC per hour; after standing for 2 hours, it was filtered and vacuum-dried to obtain 20.4 g of sucralose crystals, with a crystallization yield of 85.0%, a purity of 98.2%, and an average particle size of 40 mesh. The scanning electron microscope picture of the prepared sucralose crystal is shown in figure 1 .

Embodiment 2

[0028] Add 40 mL of sec-butyl acetate to 20 mL (24 g) of sucralose crude solution, mix and stir for 4 h at room temperature, filter to remove impurities; add 20 mL of water-ethanol mixed solution with a molar ratio of 7:3, heat up to 80 ºC, and stir to react After 2.5 hours, the temperature was lowered to 20 ºC at a rate of 10 ºC per hour; after standing for 2 hours, it was filtered and vacuum-dried to obtain 19.5 g of sucralose crystals. The crystallization yield is 81.25%, the purity is 98.5%, and the average particle size is 45 mesh.

Embodiment 3

[0030] Add 40 mL of ethyl acetate to 20 mL (24 g) of crude sucralose solution, mix and stir for 4 h at room temperature, filter to remove impurities; add 20 mL of water-methanol mixed solution with a molar ratio of 5:5, raise the temperature to 75°C, and stir to react 4 Hours, at a rate of 8 ºC per hour, the temperature was lowered to 20 ºC; after standing for 2 hours, it was filtered and vacuum-dried to obtain 22.1 g of sucralose crystals, with a crystallization yield of 92.08%, a purity of 98.8%, and an average particle size of 38 mesh.

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Abstract

The invention discloses a crystallization method of sucralose. The crystallization method comprises the following steps that a pure solvent and a crude sucralose solution are mixed and stirred, impurities are removed through filtration, and a crude sucralose raw material is obtained; a mixed solvent is added into the crude sucralose raw material, heating stirring is conducted for a reaction for awhile, and cooling is conducted at a certain speed; after cooling, standing is conducted, and after filtration, sucralose crystals are obtained. The crystallization process conditions are simple and mild, the crystallization time is short, the production cost is low, industrial production is facilitated, the purity of the sucralose obtained by using the method is high, the particles of the crystalare large, and the crystallization method has a wide market application prospect.

Description

technical field [0001] The invention belongs to the field of food application, and in particular relates to a crystallization method of sucralose. Background technique [0002] Sucralose is a new type of non-nutritive sweetener, its chemical name is 4,1',6'-trichloro-4,1',6'-trideoxygalactose, which is 4 on the sucrose molecule, The three hydroxyl groups at the 1' and 6' positions are replaced by three chlorine atoms. It has the advantages of high sweetness and no calories, and is widely used in the food industry. [0003] US5298611 describes a method of using a granulator to produce sucralose spherical crystals, which effectively increases the fluidity of sucralose and reduces dust, but increases process steps and production costs; CN101260126 describes a method that uses alcohols A method for crystallizing sucralose solids or concentrates with a mixed solvent composed of solvents or alcohols and other solvents, but this method requires a long production time and reduces p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/06C07H5/02
Inventor 郑辉东李宁馨王莹淑陈晶晶曾燕茹
Owner FUZHOU UNIV
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