Protective effect of minocycline on neuropsychiatric injury in offspring induced by stress during pregnancy

A technology of minocycline and stress, applied in nervous system diseases, active ingredients of tetracycline, drug combination, etc., can solve the problems that the neuroprotective effect of minocycline has yet to be developed

Inactive Publication Date: 2018-01-05
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, minocycline is mainly used to treat acne and other skin infections, but the neuroprotective effect of minocycline has yet to be developed

Method used

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  • Protective effect of minocycline on neuropsychiatric injury in offspring induced by stress during pregnancy
  • Protective effect of minocycline on neuropsychiatric injury in offspring induced by stress during pregnancy

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0007] Experimental Example 1. Minocycline has an improving effect on the neuron proliferation and survival of offspring pups caused by stress in pregnant rats. Experimental method:

[0008] When pregnant animals are stressed, their offspring are prone to mental illnesses such as schizophrenia, autism, and depression. In this experiment, the stress model of sleep deprivation in pregnant mice was adopted. Pregnant mice on the 18th day of late pregnancy were deprived of sleep on a small platform for 72 hours, and then the changes in neuron proliferation and survival of their offspring were observed. Coronal slices were taken from the brains of newly weaned offspring to detect the proliferation and survival (neurogenesis) of neurons in the hippocampal region of the offspring's brains. Brain neurogenesis was primarily indicated by staining for bromodeoxyuridine (BrdU) and doublecortin (DCX). The sections were double-stained with antibodies against BrdU and DCX, and then the chang...

Embodiment 2

[0015] Example 2. Minocycline inhibits the excessive proliferation of microglial cells in the offspring of stressed pregnant mice and exerts a neuroprotective effect

[0016] experimental method:

[0017] Microglia are immune cells in the brain derived from myeloid precursor cells that infiltrate into the central nervous system through blood vessels during early embryonic development. Rat microglial cells appeared at embryonic day 12-14, and then increased in number until late pregnancy, and microglial cells gradually stopped proliferating after birth. When stimulated by the external environment, microglia will be rapidly activated and proliferate. Once overactivated in the embryo, microglia assume this agitated state, which affects neuronal survival and persists into adulthood. The activation of microglia and the secretion of inflammatory cytokines play an important role in regulating the proliferation, differentiation, survival and migration of neurons. Iba1 (ionized calc...

Embodiment 3

[0024] Example 3. Minocycline reduces the expression of pro-inflammatory cytokines in the brains of offspring of stressed pregnant mice

[0025] experimental method:

[0026] Pro-inflammatory cytokine is a general term for a series of cytokines that can promote inflammation. In this experiment, the sleep deprivation stress model of pregnant mice was used, and the pregnant mice on the 18th day of late pregnancy were deprived of small platform sleep for 72 hours, and then the effect of minocycline on the expression of pro-inflammatory cytokines in the brains of the offspring mice was observed. In the experiment, 32 young mice were divided into four experimental groups: non-stress-normal saline, stress-normal saline, non-stress-minocycline and stress-minocycline, with 8 animals in each group . When the young mice were weaned (21 days after birth), they were given intraperitoneal injection of normal saline or minocycline (50 mg / kg), once every morning and evening for the first t...

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Abstract

The invention relates to the technical field of medicine and is a new application of minocycline. Animal experiments have proved that minocycline has neuroprotective effect and is a relatively promising neuroprotective drug, so it can be used to prepare drugs for treating neuropsychiatric diseases or symptoms caused by stress encountered by mothers during pregnancy.

Description

technical field [0001] The invention relates to the technical field of medicine, is a new application of minocycline in neuroprotection, and belongs to the field of drug development. Background technique [0002] In the pathogenesis of various psychiatric disorders (mental illness) such as schizophrenia, autism, depression, etc., nerve damage caused by central inflammation is common. Nerve damage here refers to damage to the central nervous system, mainly the nerve cells of the brain. Nerve cells are the structural and functional units of the nervous system of higher animals, including neurons and glial cells. In the brain, once the nerve cells are damaged, it may lead to the occurrence of mental diseases. Therefore, neuroprotection has become a target for the development of many new drugs for psychiatric diseases. [0003] At present, most antipsychotic drugs exert antipsychotic effects by blocking dopamine receptors in the brain, such as dopamine D2 receptors, serotonin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/65A61P25/00
Inventor 游自立赵秋影樊永华
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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